{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T00:35:23Z","timestamp":1772584523611,"version":"3.50.1"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T00:00:00Z","timestamp":1698364800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100018694","name":"MSCA","doi-asserted-by":"publisher","award":["Grant agreement No 860898"],"award-info":[{"award-number":["Grant agreement No 860898"]}],"id":[{"id":"10.13039\/100018694","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["asbmr.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JBMR Plus"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The incidence of major osteoporotic fractures has declined in men and women in Western countries over the last two decades. Although fracture risk is higher in persons with diabetes mellitus, trends of fractures remain unknown in men and women with diabetes. We investigated the trends in fracture incidence rates (IRs) in men and women with type 1 diabetes mellitus (T1D) and type 2 diabetes mellitus (T2D) in Denmark between 1997 and 2017. We identified men and women aged 18+ years who sustained a fracture (excluding skull and facial fractures) between 1997 and 2017 using the Danish National Patient Registry. We calculated sex\u2010specific IRs of fractures per 10,000 person\u2010years separately in persons with T1D, T2D, or without diabetes. Furthermore, we compared median IRs of the first 5\u2009years (1997\u20132002) to the median IRs of the last 5\u2009years (2012\u20132017). We identified 1,235,628 persons with fractures including 4863 (43.6% women) with T1D, 65,366 (57.5% women) with T2D, and 1,165,399 (54.1% women) without diabetes. The median IRs of fractures declined 20.2%, 19.9%, and 7.8% in men with T1D, T2D, and without diabetes, respectively (\n                    <jats:italic>p<\/jats:italic>\n                    \u2010trend &lt;0.05). The median IRs decreased 6.4% in women with T1D (\n                    <jats:italic>p<\/jats:italic>\n                    \u2010trend\u2009=\u20090.35) and 25.6% in women with T2D (\n                    <jats:italic>p<\/jats:italic>\n                    \u2010trend &lt;0.05) but increased 2.3% in women without diabetes (\n                    <jats:italic>p<\/jats:italic>\n                    \u2010trend\u2009=\u20090.08). Fracture IRs decreased in men with both diabetes types and only in women with T2D, highlighting the need for further attention behind the stable trend observed in women with T1D. \u00a9 2023 The Authors.\n                    <jats:italic>JBMR Plus<\/jats:italic>\n                    published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.\n                  <\/jats:p>","DOI":"10.1002\/jbm4.10836","type":"journal-article","created":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T01:59:02Z","timestamp":1698458342000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Sex\u2010 and Age Group\u2010Specific Fracture Incidence Rates Trends for Type 1 and 2 Diabetes Mellitus"],"prefix":"10.1093","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3525-592X","authenticated-orcid":false,"given":"Mohamad 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Aalborg University Hospital  Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9046-2967","authenticated-orcid":false,"given":"Peter","family":"Vestergaard","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center North Denmark Aalborg University Hospital  Aalborg Denmark"},{"name":"Department of Endocrinology Aalborg University Hospital  Aalborg Denmark"},{"name":"Department of Clinical Medicine Aalborg University Hospital  Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0323-3366","authenticated-orcid":false,"given":"Richard","family":"Eastell","sequence":"additional","affiliation":[{"name":"Academic Unit of Bone Metabolism University of Sheffield  Sheffield UK"},{"name":"Mellanby Centre for Musculoskeletal Research University of Sheffield  Sheffield UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7082-8530","authenticated-orcid":false,"given":"Andrea M","family":"Burden","sequence":"additional","affiliation":[{"name":"Pharmacoepidemiology Group, Institute of Pharmaceutical Sciences ETH Zurich  Zurich Switzerland"},{"name":"Leslie Dan Faculty of Pharmacy University of Toronto  Toronto Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5608-1589","authenticated-orcid":false,"given":"Morten","family":"Frost","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Molecular Endocrinology Stem Cell Research Unit (KMEB) Odense University Hospital  Odense Denmark"},{"name":"Department of Clinical Research University of Southern Denmark  Odense Denmark"},{"name":"Steno Diabetes Center Odense Odense University Hospital  Odense 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