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The physicochemical properties, biocompatibility, and in\u00a0vitro osteogenic performance of the scaffolds were characterized, and a rat model of periodontitis bone defect was constructed to evaluate the osteogenic effect of the scaffolds. Results showed that the scaffolds exhibited interconnected pore structures and appropriate mechanical properties. The contact angles were measured to be between 73.37\u00b0\u2009\u00b1\u20091.36\u00b0 and 85.03\u00b0\u2009\u00b1\u20091.45\u00b0. The composite scaffolds of the 25%, 30%, and 35% groups had a significant promoting effect on the proliferation and osteogenic differentiation of rat bone marrow mesenchymal stem cells (BMSCs). In the bone defect model, the 30% scaffold showed substantial osteogenic effects at 6\u2009weeks post\u2010implantation, characterized by significant increases in BV\/TV, BS\/TV, and area of collagen formation, along with decreased trabecular separation. At 12\u2009weeks, the volume fraction and collagen area of new bone surpassed those of Bio\u2010Oss bone graft. Immunohistochemistry indicated that this scaffold effectively inhibited expression of inflammation\u2010related factors TLR2, TLR7, and IL\u20101\u03b2. This study systematically compared the effects of CHA\/nmZnO filler content on the performance of PLGA scaffolds, and selected 30% as the optimal ratio, which has both osteogenic induction and immune regulation functions, providing a new design idea for the development of periodontal bone regeneration materials.<\/jats:p>","DOI":"10.1002\/jbma.70001","type":"journal-article","created":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T18:27:49Z","timestamp":1767032869000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Reparative Effects of\n                    <scp>3D<\/scp>\n                    \u2010Printed\n                    <scp>PLGA<\/scp>\n                    \/\n                    <scp>CHA<\/scp>\n                    \/\n                    <scp>nmZnO<\/scp>\n                    Composite Scaffolds on Inflammatory Periodontal Bone Defects in Rats"],"prefix":"10.1002","volume":"114","author":[{"given":"Chong\u2010yan","family":"Xu","sequence":"first","affiliation":[{"name":"Postgraduate Research Institute, Kunming Medical University  Kunming China"},{"name":"Department of Stomatology 920th Hospital of Joint Logistics Support Force of People's Liberation Army of China  Kunming China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Stomatology 920th Hospital of Joint Logistics Support Force of People's Liberation Army of China  Kunming China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3768-5931","authenticated-orcid":false,"given":"Ji\u2010Fan","family":"Zhan","sequence":"additional","affiliation":[{"name":"Postgraduate Research Institute, Kunming Medical University  Kunming China"},{"name":"Department of Stomatology 920th Hospital of Joint Logistics Support Force of People's 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