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Here, we present our findings on the influence of various sterilization regimes on the mechanical properties and the degradation of calcium carbonate reinforced polycaprolactone (PCL), a commonly used biomaterial for example, for bone substitution. Furthermore, studies on the impact of additives' specific surface were included. It was shown that both gamma and electron beam sterilization with direct and pulsed application of 25\u2009kGy radiation resulted in a decrease of M\n                    <jats:sub>N<\/jats:sub>\n                    and an increase of M\n                    <jats:sub>W<\/jats:sub>\n                    , corresponding to the occurrence of chain scission and branching reactions, respectively. Here, pulsation and the use of gamma rays were shown to decrease the impact of sterilization on molecular weight. Overall, sterilization resulted in an increase of Young's moduli in bulk specimens. Identical observations were made regarding an increase in specific additive surface area. In 3D\u2010printed scaffolds, however, no influence of sterilization regime or additive surface area on the mechanical properties was observed. During degradation (hydrolysis), chain scission and branching reactions have contrary effects regarding degradation velocity. Therefore, gamma\u2010sterilized specimens showed no effect, which was attributed to an offset of the effects of both modifications. Electron beam sterilization, however, inhibited degradation due to increased PCL branching reactions. This effect could be circumvented by additives with high specific surface, which showed reduced particle\u2010matrix interaction after electron beam sterilization, attributed to the generation of characteristic high\u2010energy X\u2010ray radiation and radicals in close proximity to calcium carbonate particles.\n                  <\/jats:p>","DOI":"10.1002\/jbma.70003","type":"journal-article","created":{"date-parts":[[2026,1,4]],"date-time":"2026-01-04T09:25:10Z","timestamp":1767518710000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Influence of Sterilization Regime on Mechanical Properties of Calcium Carbonate\u2010Reinforced Polycaprolactone Scaffolds for Bone Regeneration"],"prefix":"10.1002","volume":"114","author":[{"given":"Lukas","family":"Benecke","sequence":"first","affiliation":[{"name":"Institute of Material Science, Technical University Dresden  Dresden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver","family":"Lohrberg","sequence":"additional","affiliation":[{"name":"Institute of Material Science, Technical University Dresden  Dresden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9641-2728","authenticated-orcid":false,"given":"Franziska","family":"Alt","sequence":"additional","affiliation":[{"name":"Institute of Material Science, Technical University Dresden  Dresden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael Thomas","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Leibnitz\u2010Institute of Polymer Research Dresden  Dresden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chokri","family":"Cherif","sequence":"additional","affiliation":[{"name":"Institute of Material Science, Technical University Dresden  Dresden Germany"},{"name":"Institute of Textile Machinery and High Performance Material Technology, Technical University Dresden  Dresden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f6rg","family":"Neunzehn","sequence":"additional","affiliation":[{"name":"Institute of Material Science, Technical University Dresden  Dresden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0659-0238","authenticated-orcid":false,"given":"Benjamin","family":"Kruppke","sequence":"additional","affiliation":[{"name":"Institute of Material Science, Technical University Dresden  Dresden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,4]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"S.Keshlaf \u201cBiomechanische Untersuchungen an humanen allogenen Sehnentransplantaten nach Elektronenstrahl\u2010und Gammabestrahlung Dissertation Technische Universit\u00e4t Berlin \u201d2012."},{"key":"e_1_2_10_3_1","unstructured":"S.Schr\u00f6ter \u201cBiomechanische Eigenschaften humaner Spongiosa nach Gammasterilisation versus Hitzedesinfektion mit dem Lobator sd\u20131 Universit\u00e4t T\u00fcbingen \u201d2005."},{"key":"e_1_2_10_4_1","unstructured":"DIN EN ISO \u201cDIN EN ISO 11137\u20102:2023\u201308 Sterilisation von Produkten f\u00fcr die Gesundheitsf\u00fcrsorge_\u2010 Strahlen_\u2010 Teil_2: Festlegung der Sterilisationsdosis (ISO_11137\u20132:2013_+ Amd_1:2022); 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