{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T06:29:44Z","timestamp":1790404184144,"version":"4.1.0"},"reference-count":54,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T00:00:00Z","timestamp":1765238400000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomedical Materials Res"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This study details the development of electrospun nanofibrous scaffolds composed of hydroxyapatite (HAp), polycaprolactone (PCL), and silver vanadate (AgVO\n                    <jats:sub>3<\/jats:sub>\n                    ) to enhance bone regeneration. AgVO\n                    <jats:sub>3<\/jats:sub>\n                    and HAp were synthesized and integrated into PCL via electrospinning. The scaffolds were characterized using Fourier\u2010transform infrared (FTIR) spectroscopy, Raman spectroscopy, scanning electron microscopy (SEM), contact angle analysis, and antibacterial testing. A critical\u2010size tibial defect (3\u2009mm) was created in rats (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200930), which were divided into three groups: control, HAp@PCL, and AgVO\n                    <jats:sub>3<\/jats:sub>\n                    \u2013HAp@PCL. Radiographic, histological, and histomorphometric assessments were conducted at 4\u2010 and 8\u2010weeks postsurgery. The AgVO\n                    <jats:sub>3<\/jats:sub>\n                    \u2013HAp@PCL scaffolds exhibited improved hydrophilicity, homogeneous structure, and strong antibacterial activity. Cone beam computed tomography (CBCT), histological, and histomorphometry analyses revealed significantly greater bone density and organized trabecular formation in the AgVO\n                    <jats:sub>3<\/jats:sub>\n                    \u2013HAp@PCL group than in the other groups (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). These results conclusively show that AgVO\n                    <jats:sub>3<\/jats:sub>\n                    boosts scaffold bioactivity and antibacterial function, highlighting AgVO\n                    <jats:sub>3<\/jats:sub>\n                    \u2013HAp@PCL as a strong candidate for bone regeneration in dental and orthopedic uses, even with a 0.15\u2009mm thick single scaffold layer used in this study. This multifunctional scaffold may serve as a synthetic bone graft alternative in maxillofacial reconstruction and dental surgery, particularly where infection control is critical.\n                  <\/jats:p>","DOI":"10.1002\/jbma.70012","type":"journal-article","created":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T20:39:59Z","timestamp":1765312799000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Silver Vanadate\u2013Hydroxyapatite Nanofibrous Scaffolds for Enhanced Bone Regeneration and Infection Control in a Rat Tibial Defect Model"],"prefix":"10.1002","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9494-5301","authenticated-orcid":false,"given":"Sara A.","family":"Swidan","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology, Faculty of Dentistry Suez Canal University  Ismailia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hagar M.","family":"Mahdy","sequence":"additional","affiliation":[{"name":"Department of Physics, Faculty of Science Suez Canal University  Ismailia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4576-7646","authenticated-orcid":false,"given":"Hanan","family":"Hendawy","sequence":"additional","affiliation":[{"name":"Department of Veterinary Surgery, Faculty of Veterinary Medicine Suez Canal University  Ismailia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asmaa","family":"Youssry","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Radiology, Faculty of Dentistry Suez Canal University  Ismailia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghada A.","family":"Abdel\u2010Latif","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology, Faculty of Dentistry Suez Canal University  Ismailia Egypt"},{"name":"Department of Oral and Maxillofacial Diagnostic Sciences Taibah University, College of Dentistry  Madinah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jor.2013.12.005"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.112570"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26073085"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13018\u2010025\u201005857\u20102"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym13071095"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tice.2022.101748"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.iecr.1c02165"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2TB01182D"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/00914037.2024.2372795"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2020.09.001"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/23311916.2023.2228069"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.22203\/eCM.v013a01"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.139.2.5751"},{"key":"e_1_2_9_15_1","first-page":"13","article-title":"Animal Models of Osteoporosis\u2014Necessity and Limitations","volume":"1","author":"Turner A. 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