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Biomimetically mineralized collagen is a nanocomposite material that closely resembles the natural bone matrix in composition and structure and has proven potential for filling bone defects. Since the mineral phase hydroxyapatite can bind proteins, the aim of the present study was to explore this biomaterial as a delivery system for the osteoinductive factor bone morphogenetic protein\u20102 (BMP\u20102) and to investigate the dependence of BMP\u20102 release on the mineral content. Three\u2010dimensional scaffolds with varying mineral content were prepared by blending biomimetically mineralized collagen and non\u2010mineralized collagen suspensions, followed by freeze\u2010drying and chemical crosslinking. While the average pore size decreased, the stiffness of the scaffolds increased with increasing mineral content; all scaffold variants exhibited a fundamentally elastic behavior. After loading, the release of BMP\u20102 was investigated over 28\u2009days. A significant influence of the mineral content on the release kinetics of BMP\u20102 was observed\u2014the higher the mineral content, the stronger the retention of BMP\u20102 in the scaffolds. In contrast, the release of the vascular growth factor\u2010A (VEGF\u2010A), which was examined for comparison, was hardly influenced by the mineral content, indicating a low retention of VEGF\u2010A by binding to the mineral phase. In summary, adjustment of the mineral content opens up the possibility of controlling the release of BMP\u20102 in a customized manner, but this is not transferable to VEGF\u2010A.<\/jats:p>","DOI":"10.1002\/jbma.70021","type":"journal-article","created":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T17:34:02Z","timestamp":1767116042000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Mineralized Collagen: Adaptation of the Mineral Content to Control\n                    <scp>BMP<\/scp>\n                    \u20102 Delivery"],"prefix":"10.1002","volume":"114","author":[{"given":"Leonie","family":"Schlicht","sequence":"first","affiliation":[{"name":"Centre for Translational Bone, Joint, and Soft Tissue Research, Faculty of Medicine Technische Universit\u00e4t Dresden  Dresden 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