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Tp and LC were homogeneously incorporated into SF and PVA, respectively, and electrospun under optimized voltage and flow conditions to yield defect\u2010free fibers. Morphological analysis confirmed a consistent nanofiber diameter and a water uptake of 364.17%\u2009\u00b1\u200942.25%, while in\u00a0vitro degradation in PBS progressed to 45.74%\u2009\u00b1\u20093.99% mass loss after 28\u2009days. Tensile testing demonstrated a breaking strength of 5.39\u2009MPa, indicating sufficient mechanical integrity for wound application. Drug\u2010release assays revealed a biphasic profile for Tp\u2014an initial burst of 666.31\u2009\u00b1\u20096.85\u2009\u03bcg\/mL within the first 24\u2009h, followed by sustained liberation over 4\u2009weeks\u2014whereas curcumin exhibited a steady release rate. Cytocompatibility studies on dermal fibroblasts showed 80.88%\u2009\u00b1\u20091.60% viability, and hemolysis remained below 0.13%\u2009\u00b1\u20090.03%, confirming hemocompatibility. In antimicrobial evaluations, the composite dressings achieved synergistic antibactericidal activity against\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    <\/jats:styled-content>\n                    and\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                    <\/jats:styled-content>\n                    , outperforming single\u2010agent controls. These findings substantiate the T@S\/LC@P scaffold as a versatile, infection\u2010resistant dressing, promising accelerated wound healing and preventing microbial colonization.\n                  <\/jats:p>","DOI":"10.1002\/jbma.70040","type":"journal-article","created":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T01:23:36Z","timestamp":1772760216000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Electrospun Silk Fibroin\/Poly(Vinyl Alcohol) Nanofibrous Dressings Co\u2010Loaded With Teicoplanin and Liposomal Curcumin: Fabrication, Physicochemical Characterization, and Antibacterial Performance"],"prefix":"10.1002","volume":"114","author":[{"given":"Fariba Alizadeh","family":"Eghtedar","sequence":"first","affiliation":[{"name":"Tissue Engineering Research Group (TERG), Department of Anatomy and Cell Biology School of Medicine, Mashhad University of Medical Sciences  Mashhad 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