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Vancomycin (VAN) is sometimes delivered locally during surgery; however, levels diminish rapidly, leaving patients vulnerable to late\u2010onset infections. We developed a composite hydrogel integrating perfluorohexane\u2010based emulsions within alginate or fibrin matrices to enable both sustained and ultrasound\u2010triggered VAN release. Water\u2010in\u2010oil\u2010in\u2010water emulsions were prepared using fluorosurfactant\u2010stabilized perfluorohexane as the volatile oil phase, then embedded in hydrogels and exposed to ultrasound (2.5\u2009MHz, 5.5\u2009MPa peak negative pressure) to initiate acoustic droplet vaporization for triggered release. Drug release was quantified spectrophotometrically and with fluorescent\u2010labeled VAN, while antibacterial efficacy was tested against\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    <\/jats:styled-content>\n                    . Hydrogels directly loaded with free VAN exhibited burst release (~55%\u201367% within 24\u2009h) followed by limited sustained release, which is suboptimal for prolonged coverage. In contrast, emulsion\u2010loaded hydrogels reduced premature leakage, retaining &gt;\u200970% VAN on Day 1 and providing gradual baseline release. Ultrasound application enhanced VAN release up to 8.75\u2010fold in alginate and 27.5\u2010fold in fibrin hydrogels after 7\u2009days (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001), supporting both continuous and on\u2010demand delivery. Only alginate\u2010emulsion hydrogels showed measurable antibacterial activity, as drug\u2010matrix interactions in fibrin prevented release; ultrasound\u2010treated samples displayed significantly greater efficacy over 7\u2009days (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05 vs. no ultrasound). This dual\u2010mode delivery platform enables spatial and temporal control of VAN release, combining early prophylaxis with ultrasound\u2010triggered reinforcement, and holds promise for improving infection prevention in orthopedic surgeries by aligning drug delivery with clinical timelines.\n                  <\/jats:p>","DOI":"10.1002\/jbma.70046","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T04:53:56Z","timestamp":1770612836000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Controlled Antibiotic Release From Emulsion\u2010Loaded Alginate and Fibrin Hydrogels Using Ultrasound"],"prefix":"10.1002","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7441-5282","authenticated-orcid":false,"given":"Ziba Ghareh Nazi","family":"Fam","sequence":"first","affiliation":[{"name":"Department of Radiology Thomas Jefferson University  Philadelphia Pennsylvania 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