{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T07:49:29Z","timestamp":1765784969692,"version":"3.48.0"},"reference-count":28,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T00:00:00Z","timestamp":1764374400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>In this work, we generate Janus\u2010type microbubbles that have distinct morphological patterns by utilizing microfluidics technology. A V\u2010Junction Microfluidic (VJM) device was designed through a Solidworks program with three inlets and one microfluidic outlet attached at 30\u00b0 to produce a closed system. 3% wt. PLA and 3% wt. PEG were chosen owing to the distinct physicochemical features of these polymers. Two hundred and seventy\u2010five microliters\/min PLA and 180\u2009\u03bcL\/min PEG were fed into the system with a nitrogen gas pressure of 12\u2009kPa, where five different solvents produced Janus\u2010type microbubbles. In addition, the effect of the change in inlet velocity of nitrogen gas on the composition of the solutions, volume fraction, and density changes was numerically examined. The results indicate that honeycomb structures and particle formation were observed at different scales, ranging from 854\u2009\u00b1\u200949\u2009nm to 6.5\u2009\u00b1\u20090.5\u2009\u03bcm. Numerical analysis showed that the speed associated with the 3\u2009wt.% PLA and 3\u2009wt.% PEG solutions had a direct effect on phase formation. Numerical results also showed that the difference in the inlet velocity of nitrogen gas in the apparatus can play a significant role in the composition of the solutions; this change may also affect the formation of microbubbles.<\/jats:p>","DOI":"10.1002\/jbmb.70006","type":"journal-article","created":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T08:36:47Z","timestamp":1764405407000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Nanosize Polymeric Foams and Microparticles Prepared In\u00a0Situ From Janus\u2010Type Microbubble Constitutions"],"prefix":"10.1002","volume":"113","author":[{"given":"Tugce","family":"Yesilyurt","sequence":"first","affiliation":[{"name":"Center for Nanotechnology &amp; Biomaterials Application and Research (NBUAM) Marmara University  Istanbul Turkey"},{"name":"Department of Bioengineering, Faculty of Chemistry and Metallurgy Y\u0131ld\u0131z Technical University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumeyye","family":"Cesur","sequence":"additional","affiliation":[{"name":"Center for Nanotechnology &amp; Biomaterials Application and Research (NBUAM) Marmara University  Istanbul Turkey"},{"name":"Department of Metallurgical and Materials Engineering, Faculty of Technology Marmara University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Onur","family":"Alpt\u00fcrk","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science and Literature \u0130stanbul Technical University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elif Damla","family":"Ar\u0131san","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics Gebze Technical University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u0131nar","family":"Obakan","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics Medeniyet University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7512-5997","authenticated-orcid":false,"given":"Savas","family":"Evran","sequence":"additional","affiliation":[{"name":"Department of Jewelry and Jewelry Design, Faculty of Applied Sciences Marmara University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oguzhan","family":"Gunduz","sequence":"additional","affiliation":[{"name":"Center for Nanotechnology &amp; Biomaterials Application and Research (NBUAM) Marmara University  Istanbul Turkey"},{"name":"Department of Metallurgical and Materials Engineering, Faculty of Technology Marmara University  Istanbul Turkey"},{"name":"Health Biotechnology Joint Research and Application Center of Excellence  Istanbul T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esma","family":"\u00d6zerol","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, Faculty of Chemistry and Metallurgy Y\u0131ld\u0131z Technical University  Istanbul Turkey"},{"name":"Health Biotechnology Joint Research and Application Center of Excellence  Istanbul T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger","family":"Narayan","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering North Carolina State University  Raleigh North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cem Bulent","family":"Ustundag","sequence":"additional","affiliation":[{"name":"Center for Nanotechnology &amp; 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