{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T20:41:46Z","timestamp":1773002506534,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:00:00Z","timestamp":1770336000000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2026,2]]},"abstract":"ABSTRACT<\/jats:title>\n \n Epilepsy is the second most prevalent neurological disorder worldwide. It is mostly identified by abnormal electrical activity in multiple brain regions. The massive influx of Ca\n 2+<\/jats:sup>\n into neurons is the main neurotoxic mechanism that leads to cell death and eventually neurodegeneration. Despite the abundance of antiseizure medications, many patients with refractory epilepsy do not benefit from the treatment. Nanomedicine is a viable alternative for boosting the central nervous system's bioavailability of anti\u2010seizure medications. This study examined the anti\u2010epileptic effects of CuNPs@\n Boswellia thurifera<\/jats:italic>\n in Swiss albino mice using experimental epilepsy models. Advanced methods like fourier transform infrared spectroscopy (FT\u2010IR), field emission scanning electron microscopy (FE\u2010SEM), X\u2010ray diffraction (XRD), and energy dispersive X\u2010ray (EDX) were used to examine the material's structural properties. The 6\u2010Hz\u2010induced seizure model was first used to assess the effectiveness of CuNPs@\n \n B. thurifera<\/jats:italic>\n <\/jats:styled-content>\n . Using an actophotometer, the strong CuNPs@\n \n B. thurifera<\/jats:italic>\n <\/jats:styled-content>\n were tested for their ability to reduce locomotor activity. The effectiveness of the CuNPs@\n \n B. thurifera<\/jats:italic>\n <\/jats:styled-content>\n on the GABA levels in the brain was also examined in order to investigate their potential method of action. The effectiveness of the nanoparticles in producing maximal electroshock (MES) and convulsions induced by pentylenetetrazole (PTZ) was next assessed. CuNPs@\n \n B. thurifera<\/jats:italic>\n <\/jats:styled-content>\n at either of the 100 or 200\u2009\u03bcg\/kg doses demonstrated a notable rise in brain gamma\u2010aminobutyric acid (GABA) levels but no influence on locomotor activity. Notably, a higher dosage of the nanocomposite and diazepam successfully prevented convulsions in all anticonvulsant studies. It should be mentioned that CuNPs@\n \n B. thurifera<\/jats:italic>\n <\/jats:styled-content>\n has demonstrated remarkable protection against seizures caused by PTZ and MES, with the level of protection varying across doses. Building on these findings, the CuNPs@\n \n B. thurifera<\/jats:italic>\n <\/jats:styled-content>\n was subsequently examined in MES and PTZ models. The CuNPs@\n \n B. thurifera<\/jats:italic>\n <\/jats:styled-content>\n at doses of 100 and 200\u2009\u03bcg\/kg showed a significant decrease in 6\u2010Hz\u2010induced seizures. These results suggest that CuNPs@\n \n B. thurifera<\/jats:italic>\n <\/jats:styled-content>\n has potent anticonvulsant effects, possibly due to its capacity to increase GABA levels in the brain.\n <\/jats:p>","DOI":"10.1002\/jbmb.70017","type":"journal-article","created":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T02:54:28Z","timestamp":1770432868000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Application of Copper Nanoparticles Green Formulated by\n \n Boswellia thurifera<\/i>\n <\/scp>\n in the Treatment of Epilepsy"],"prefix":"10.1002","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-4046-7326","authenticated-orcid":false,"given":"Hongyan","family":"Ke","sequence":"first","affiliation":[{"name":"Department of Neurology Huanggang Central Hospital Huanggang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4739-1868","authenticated-orcid":false,"given":"Liping","family":"Fang","sequence":"additional","affiliation":[{"name":"Internal Medicine Huanggang Central Hospital Huanggang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6468-3218","authenticated-orcid":false,"given":"Jing","family":"Zheng","sequence":"additional","affiliation":[{"name":"School of Nursing Huanggang Polytechnic College Huanggang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4443-5574","authenticated-orcid":false,"given":"Chunli","family":"Zhang","sequence":"additional","affiliation":[{"name":"Nursing Department Huanggang Central Hospital Huanggang China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15020306"},{"issue":"1","key":"e_1_2_11_3_1","first-page":"S121","article-title":"Biodegradable Nanoparticles for the Treatment of Epilepsy: From Current Advances to Future Challenges","volume":"7","author":"Bonilla L.","year":"2022","journal-title":"Epilepsia Open"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1515\/gps-2023-0022"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/nano15020091"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2019.05.017"},{"key":"e_1_2_11_7_1","unstructured":"World Health Organization \u201cEpilepsy \u201d2022."},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/epi4.12375"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.118826"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.4103\/tcmj.tcmj_65_22"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.1c00938"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-021-00864-x"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/nano10040656"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389200215666141125142605"},{"key":"e_1_2_11_15_1","first-page":"200","article-title":"Anticonvulsant Effect of the Aqueous Extract and Essential Oil of \n Carum carvi\n L. 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