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Physics\u2010based mass\u2010transport models can estimate patient exposure but require knowledge of the initial leachable amount, . Although  can be determined through exhaustive extraction testing, this may be impractical for some solutes due to kinetic or thermodynamic limitations. We developed a free\u2010volume model to estimate  from non\u2010exhaustive extractions, accounting for solvent\u2010swelling effects on solute diffusivity, , in polymers. Based on an analysis of polymer\/solvent partition coefficients, we also propose a limiting value for the partition coefficient . We couple this model to a mass\u2010transport equation to predict . Validation against experimental data demonstrates order\u2010of\u2010magnitude accuracy for both  and . The model is applicable only to rubbery polymers and systems involving relatively hydrophobic polymers, solvents, and solutes. Using the predicted  with a transport model for in\u00a0vivo exposure yields results similar to those obtained when  is known a priori. Our work shows that non\u2010exhaustive extractions can be used to infer total extractable quantities and conservatively estimate patient exposure.<\/jats:p>","DOI":"10.1002\/jbmb.70024","type":"journal-article","created":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T09:03:42Z","timestamp":1766999022000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Physics\u2010Based Models of Extraction Kinetics in Solvent\u2010Swollen Polymers: Using Non\u2010Exhaustive Extractions to Estimate Total Extractable Quantities"],"prefix":"10.1002","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5052-3841","authenticated-orcid":false,"given":"Robert M.","family":"Elder","sequence":"first","affiliation":[{"name":"Center for Devices and Radiological Health, FDA  Silver Spring Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaleb J.","family":"Duelge","sequence":"additional","affiliation":[{"name":"Center for Devices and Radiological Health, FDA  Silver Spring Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nimesh P. 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