{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T22:50:31Z","timestamp":1789426231306,"version":"build-2803163510"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2010,4,30]],"date-time":"2010-04-30T00:00:00Z","timestamp":1272585600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Differences in bone mineral density (BMD) patterns have been recently reported between multiple endocrine neoplasia type 1\u2013related primary hyperparathyroidism (HPT\/MEN1) and sporadic primary HPT. However, studies on the early and later outcomes of bone\/renal complications in HPT\/MEN1 are lacking. In this cross-sectional study, performed in a tertiary academic hospital, 36 patients cases with uncontrolled HPT from 8 unrelated MEN1 families underwent dual-energy X-ray absorptiometry (DXA) scanning of the proximal one-third of the distal radius (1\/3DR), femoral neck, total hip, and lumbar spine (LS). The mean age of the patients was 38.9\u2009\u00b1\u200914.5 years. Parathyroid hormone (PTH)\/calcium values were mildly elevated despite an overall high percentage of bone demineralization (77.8%). In the younger group (&amp;lt;50 years of age), demineralization in the 1\/3DR was more frequent, more severe, and occurred earlier (40%; Z-score \u22121.81\u2009\u00b1\u20090.26). The older group (&amp;gt;50 years of age) had a higher frequency of bone demineralization at all sites (p\u2009&amp;lt;\u2009.005) and a larger number of affected bone sites (p\u2009&amp;lt;\u2009.0001), and BMD was more severely compromised in the 1\/3DR (p\u2009=\u2009.007) and LS (p\u2009=\u2009.002). BMD values were lower in symptomatic (88.9%) than in asymptomatic HPT patients (p\u2009&amp;lt;\u2009.006). Patients with long-standing HPT (&amp;gt;10 years) and gastrinoma\/HPT presented significantly lower 1\/3DR BMD values. Urolithiasis occurred earlier (&amp;lt;30 years) and more frequently (75%) and was associated with related renal comorbidities (50%) and renal insufficiency in the older group (33%). Bone mineral\u2013 and urolithiasis-related renal complications in HPT\/MEN1 are early-onset, frequent, extensive, severe, and progressive. These data should be considered in the individualized clinical\/surgical management of patients with MEN1-associated HPT. \u00a9 2010 American Society for Bone and Mineral Research.<\/jats:p>","DOI":"10.1002\/jbmr.125","type":"journal-article","created":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T10:44:02Z","timestamp":1272710642000},"page":"2382-2391","source":"Crossref","is-referenced-by-count":78,"title":["Early-onset, progressive, frequent, extensive, and severe bone mineral and renal complications in multiple endocrine neoplasia type 1\u2013associated primary hyperparathyroidism"],"prefix":"10.1093","volume":"25","author":[{"suffix":"Jr","given":"Delmar M","family":"Louren\u00e7o","sequence":"first","affiliation":[{"name":"Endocrine Genetics Unit (LIM-25), Division of Endocrinology, University of S\u00e3o Paulo School of Medicine, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia L","family":"Coutinho","sequence":"additional","affiliation":[{"name":"Endocrine Genetics Unit (LIM-25), Division of Endocrinology, University of S\u00e3o Paulo School of Medicine, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo A","family":"Toledo","sequence":"additional","affiliation":[{"name":"Endocrine Genetics Unit (LIM-25), Division of Endocrinology, University of S\u00e3o Paulo School of Medicine, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio LM","family":"Montenegro","sequence":"additional","affiliation":[{"name":"Division of Head and Neck Surgery, Hospital das Cl\u00ednicas, University of S\u00e3o Paulo School of Medicine, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joya EM","family":"Correia-Deur","sequence":"additional","affiliation":[{"name":"Endocrine Genetics Unit (LIM-25), Division of Endocrinology, University of S\u00e3o Paulo School of Medicine, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio PA","family":"Toledo","sequence":"additional","affiliation":[{"name":"Endocrine Genetics Unit (LIM-25), Division of Endocrinology, University of S\u00e3o Paulo School of Medicine, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2010,4,30]]},"reference":[{"key":"2024020320073182800_bib1","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1038\/ncpendmet0265","article-title":"The diagnosis and management of asymptomatic primary hyperparathyroidism","volume":"2","author":"Silverberg","year":"2006","journal-title":"Nat Clin Pract Endocrinol Metab."},{"key":"2024020320073182800_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2265.2007.03162.x","article-title":"Primary hyperparathyroidism and the 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