{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T15:13:50Z","timestamp":1790867630864,"version":"4.1.0"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2010,4,30]],"date-time":"2010-04-30T00:00:00Z","timestamp":1272585600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>In order to gain insight into the mechanisms underlying the dynamic changes in bone metabolism and bone quality after parathyroidectomy (PTX) in secondary hyperparathyroid patients with high levels of parathyroid hormone (PTH), we performed bone histomorphometric analysis with tetracycline labeling in iliac bone biopsy specimens taken before and after PTX, with special attention paid to osteocytes. At 2 to 4 weeks after PTX, PTH concentrations decreased markedly with evident reductions in bone turnover markers. Histomorphometry revealed that at 2 to 4 weeks following PTX, the osteoclast surface decreased to nearly 0%, with a substantial increase in osteoid volume and a reduction in fibrosis volume. Labeling with tetracycline was observed not only at the mineralization front on the bone surface but also around the osteocyte lacunar walls and canaliculi within both the basic multicellular units (BMUs) and bone structural units (BSUs), suggesting that mineralization was taking place along the lacunocanalicular system after PTX. The tetracycline-labeled area was much greater in the BSUs than in the BMUs and at the mineralization front, and the tetracycline labeling in the BSUs was markedly increased after PTX compared with that in the low- and high-PTH control groups without PTX. The osteocyte number was decreased significantly after PTX, concomitant with an increase in the number of empty lacunae and a reduction of lacunar volume. Thus the increased osteocyte death and mineralization around the lacunocanalicular system in association with a rapid decline in PTH may underlie the changes in bone metabolism and quality that occur following PTX. \u00a9 2010 American Society for Bone and Mineral Research.<\/jats:p>","DOI":"10.1002\/jbmr.126","type":"journal-article","created":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T10:44:10Z","timestamp":1272710650000},"page":"2374-2381","source":"Crossref","is-referenced-by-count":52,"title":["Increased osteocyte death and mineralization inside bone after parathyroidectomy in patients with secondary hyperparathyroidism"],"prefix":"10.1093","volume":"25","author":[{"given":"Aiji","family":"Yajima","sequence":"first","affiliation":[{"name":"Department of Nephrology, Towa Hospital, Adachi-ku, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaaki","family":"Inaba","sequence":"additional","affiliation":[{"name":"Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Abeno-ku, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Tominaga","sequence":"additional","affiliation":[{"name":"Department of Transplant Surgery, Nagoya Second Red Cross Hospital, Nagoya, Aichi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiki","family":"Nishizawa","sequence":"additional","affiliation":[{"name":"Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Abeno-ku, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoji","family":"Ikeda","sequence":"additional","affiliation":[{"name":"National Center for Geriatrics and Gerontology, Obu, Aichi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akemi","family":"Ito","sequence":"additional","affiliation":[{"name":"Ito Bone Histomorphometry Institute, Niigata, Niigata, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2010,4,30]]},"reference":[{"key":"2024020320070725000_bib1","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1002\/9780470623992.ch73","volume-title":"Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism","author":"Hruska","year":"2008","edition":"7th ed"},{"key":"2024020320070725000_bib2","first-page":"S22","article-title":"KDIGO clinical practice guideline for the diagnosis, evaluation, prevention, and treatment of chronic kidney disease: mineral and bone disorders (CKD-MBD). Chapter 3. 1: Diagnosis of CKD-MBD: biochemical abnormalities","volume":"76","author":"Moe","year":"2009","journal-title":"Kidney Int."},{"key":"2024020320070725000_bib3","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/ki.1993.64","article-title":"The spectrum of bone disease in end-stage renal failure: an evolving disorder","volume":"43","author":"Sherrard","year":"1993","journal-title":"Kidney Int."},{"key":"2024020320070725000_bib4","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1053\/j.ajkd.2003.12.004","article-title":"Osteoporosis in chronic kidney disease. Osteoporosis Work Group","volume":"43","author":"Cunningham","year":"2004","journal-title":"Am J Kidney Dis."},{"key":"2024020320070725000_bib5","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1046\/j.1523-1755.2000.00178.x","article-title":"Increased risk of hip fracture among patients with end-stage renal disease","volume":"58","author":"Alem","year":"2000","journal-title":"Kidney Int."},{"key":"2024020320070725000_bib6","doi-asserted-by":"crossref","first-page":"3845","DOI":"10.1210\/jcem.83.11.5249","article-title":"Bone mineral recovery after parathyroidectomy in patients with primary and renal hyperparathyroidism","volume":"83","author":"Abdelhadi","year":"1998","journal-title":"J Clin Endocrinol Metab."},{"key":"2024020320070725000_bib7","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1681\/ASN.2007010022","article-title":"Fracture risk after parathyroidectomy among chronic hemodialysis patients","volume":"18","author":"Rudser","year":"2007","journal-title":"J Am Soc Nephrol."},{"key":"2024020320070725000_bib8","doi-asserted-by":"crossref","first-page":"2250","DOI":"10.1056\/NEJMra053077","article-title":"Review; Bone Quality-The material and structural basis of bone strength and fragility","volume":"354","author":"Seeman","year":"2006","journal-title":"N Engl J Med."},{"key":"2024020320070725000_bib9","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1196\/annals.1402.018","article-title":"Osteocytes as dynamic multifunctional cells","volume":"1116","author":"Bonewald","year":"2007","journal-title":"Ann N Y Acad Sci."},{"key":"2024020320070725000_bib10","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1093\/ndt\/gfl837","article-title":"Significance of time-course changes of serum bone markers after parathyroidectomy in patients with uraemic hyperparathyroidism","volume":"22","author":"Yajima","year":"2007","journal-title":"Nephrol Dial Transplant."},{"key":"2024020320070725000_bib11","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/S0272-6386(03)00909-0","article-title":"Changes of bone remodeling immediately after parathyroidectomy for secondary hyperparatghyroidism","volume":"42","author":"Yajima","year":"2003","journal-title":"Am J Kidney Dis."},{"key":"2024020320070725000_bib12","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/ki.2008.242","article-title":"Bone formation by minimodeling is more active than remodeling after parathyroidectomy","volume":"78","author":"Yajima","year":"2008","journal-title":"Kidney Int."},{"key":"2024020320070725000_bib13","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1002\/jbmr.5650020617","article-title":"Bone histomorphometry: standardization of nomenclature, symbols, and units","volume":"2","author":"Parfitt","year":"1987","journal-title":"J Bone Miner Res."},{"key":"2024020320070725000_bib14","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/8756-3282(95)00444-0","article-title":"Osteocyte density changes in aging and osteoporosis","volume":"18","author":"Mullender","year":"1996","journal-title":"Bone."},{"key":"2024020320070725000_bib15","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1359\/jbmr.2003.18.9.1657","article-title":"Reduced iliac cancellous osteocyte density in patients with osteoporotic vertebral fracture","volume":"18","author":"Qiu","year":"2003","journal-title":"J Bone Miner Res."},{"key":"2024020320070725000_bib16","doi-asserted-by":"crossref","first-page":"e2942","DOI":"10.1371\/journal.pone.0002942","article-title":"Control of bone mass and remodeling by PTH receptor signaling in osteocytes","volume":"3","author":"O'Brien","year":"2008","journal-title":"PLoS ONE."},{"key":"2024020320070725000_bib17","first-page":"245","article-title":"PTH receptor and apoptosis","volume":"2","author":"Bringhurst","year":"2002","journal-title":"J Musculoskel Neuron Interact."},{"key":"2024020320070725000_bib18","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0002-9343(99)00420-9","article-title":"Apoptosis and osteoporosis","volume":"108","author":"Weinstein","year":"2000","journal-title":"Am J Med."},{"key":"2024020320070725000_bib19","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1002\/ajpa.20886","article-title":"The mineralized osteocyte; A living fossil","volume":"137","author":"Bell","year":"2008","journal-title":"Am J Physiol Anthropol."},{"key":"2024020320070725000_bib20","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1002\/jcb.240550304","article-title":"Function of osteocytes in bone","volume":"55","author":"Aarden","year":"1994","journal-title":"J Cell Biochem."},{"key":"2024020320070725000_bib21","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/j.bone.2004.07.002","article-title":"Osteocyte density in woven bone","volume":"35","author":"Hernandez","year":"2004","journal-title":"Bone."},{"key":"2024020320070725000_bib22","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/ki.1990.187","article-title":"Renal bone disease 1990-an unmet challenge for the nephrologists","volume":"38","author":"Malluche","year":"1990","journal-title":"Kidney Int."},{"key":"2024020320070725000_bib23","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s11914-003-0002-y","article-title":"Osteocyte and bone structure","volume":"1","author":"Klein-Nulend","year":"2003","journal-title":"Curr Osteoporos Rep."}],"container-title":["Journal of Bone and Mineral Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbmr.126","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbmr.126","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/25\/11\/2374\/56577475\/jbmr126.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/25\/11\/2374\/56577475\/jbmr126.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T10:45:28Z","timestamp":1710326728000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbmr\/article\/25\/11\/2374-2381\/7600117"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4,30]]},"references-count":23,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2010,4,30]]},"published-print":{"date-parts":[[2010,11,1]]}},"URL":"https:\/\/doi.org\/10.1002\/jbmr.126","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.7605956.7908054","asserted-by":"object"}]},"ISSN":["0884-0431","1523-4681"],"issn-type":[{"value":"0884-0431","type":"print"},{"value":"1523-4681","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2010,11,1]]},"published":{"date-parts":[[2010,4,30]]}}}