{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T01:25:07Z","timestamp":1776216307114,"version":"3.50.1"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2011,12,8]],"date-time":"2011-12-08T00:00:00Z","timestamp":1323302400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Some patients sustain fractures while on antiresorptives. Whether this represents an inadequate response (IR) to treatment or a chance event has not been elucidated. We performed a study to identify which patients are more likely to fracture while on treatment. This is a multicentric, cross-sectional study of postmenopausal women on antiresorptives for osteoporosis in 12 Spanish hospitals, classified as adequate responders (ARs) if on treatment with antiresorptives for 5 years with no incident fractures or inadequate responders (IRs) if an incident fracture occurred between 1 and 5 years on treatment. Poor compliance, secondary osteoporosis, and previous anti-osteoporosis treatment other than the assessed were exclusion criteria. Clinical, demographic, analytical, dual-energy X-ray absorptiometry (DXA) variables, and proximal femur structure analysis (ImaTx\u2122) and structural\/fractal analyses of distal radius were performed. A total of 179 women (76 IRs; mean (SD): age 68.2 (9.0) years; 103 ARs, age 68.5 (7.9) years) were included. History of prior fracture (p\u2009=\u20090.005), two or more falls in the previous year (p\u2009=\u20090.032), low lumbar spine bone mineral density (BMD) (p\u2009=\u20090.02), 25 hydroxyvitamin D (p\u2009=\u20090.017), and hip ImaTx fracture load index (p\u2009=\u20090.004) were associated with IR. In the logistic regression models a fracture before treatment (odds ratio [OR], 3.60; 95% confidence interval [CI], 1.47\u20138.82; p\u2009=\u20090.005) and levels of 25 hydroxyvitamin D below 20\u2009ng\/mL (OR, 3.89; 95% CI, 1.55\u20139.77; p\u2009=\u20090.004) significantly increased risk for IR, while increased ImaTx fracture load (OR, 0.96; 95% CI, 0.93\u20130.99; p\u2009=\u20090.006; per every 100 units) was protective, although the latter became not significant when all three variables were fitted into the model. Therefore, we can infer that severity of the disease, with microarchitectural and structure deterioration, as shown by previous fracture and hip analysis, and low levels of 25 hydroxy vitamin D carry higher risk of inadequate response to antiresorptives. More potent regimes should be developed and adequate supplementation implemented to solve this problem. \u00a9 2012 American Society for Bone and Mineral Research.<\/jats:p>","DOI":"10.1002\/jbmr.1496","type":"journal-article","created":{"date-parts":[[2011,12,8]],"date-time":"2011-12-08T16:01:11Z","timestamp":1323360071000},"page":"817-824","source":"Crossref","is-referenced-by-count":60,"title":["Risk factors for prediction of inadequate response to antiresorptives"],"prefix":"10.1093","volume":"27","author":[{"given":"Adolfo","family":"D\u00edez-P\u00e9rez","sequence":"first","affiliation":[{"name":"RETICEF, Instituto Carlos III, Barcelona, Spain"},{"name":"Hospital del Mar-IMIM-UAB, Department of Internal Medicine, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose M","family":"Olmos","sequence":"additional","affiliation":[{"name":"Hospital Universitario Marqu\u00e9s de Valdecilla, Department of Internal Medicine, Santander, Spain"},{"name":"RETICEF, Instituto Carlos III, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xavier","family":"Nogu\u00e9s","sequence":"additional","affiliation":[{"name":"RETICEF, Instituto Carlos III, Barcelona, Spain"},{"name":"Hospital del Mar-IMIM-UAB, Department of Internal Medicine, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Sosa","sequence":"additional","affiliation":[{"name":"Grupo de Investigaci\u00f3n en Osteoporosis, Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"D\u00edaz-Curiel","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Department of Internal Medicine, Madrid, Spain"},{"name":"RETICEF, Instituto Carlos III, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose Luis","family":"P\u00e9rez-Castrill\u00f3n","sequence":"additional","affiliation":[{"name":"Hospital Universitario Rio Hortega, Department of Internal Medicine, Valladolid, Spain"},{"name":"RETICEF, Instituto Carlos III, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramon","family":"P\u00e9rez-Cano","sequence":"additional","affiliation":[{"name":"Hospital Virgen Macarena, Department of Internal Medicine, Sevilla, Spain"},{"name":"RETICEF, Instituto Carlos III, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Mu\u00f1oz-Torres","sequence":"additional","affiliation":[{"name":"Hospital Universitario San Cecilio, Department of Endocrinology, Granada, Spain"},{"name":"RETICEF, Instituto Carlos III, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Torrijos","sequence":"additional","affiliation":[{"name":"Hospital La Paz, Department of Rheumatology, Madrid, Spain"},{"name":"RETICEF, Instituto Carlos III, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esteban","family":"Jodar","sequence":"additional","affiliation":[{"name":"Hospital Universitario Quir\u00f3n, Department of Endocrinology, Madrid, Spain"},{"name":"RETICEF, Instituto Carlos III, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Del Rio","sequence":"additional","affiliation":[{"name":"CETIR Centro M\u00e9dico, Barcelona, Spain"},{"name":"RETICEF, Instituto Carlos III, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose R","family":"Caeiro-Rey","sequence":"additional","affiliation":[{"name":"Trabeculae, Ourense, Spain"},{"name":"RETICEF, Instituto Carlos III, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordi","family":"Farrerons","sequence":"additional","affiliation":[{"name":"Hospital Sant Pau, Department of Internal Medicine, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan","family":"Vila","sequence":"additional","affiliation":[{"name":"Hospital del Mar-IMIM-UAB, Department of Internal Medicine, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claude","family":"Arnaud","sequence":"additional","affiliation":[{"name":"Imaging Therapeutics, Redwood City, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesus","family":"Gonz\u00e1lez-Mac\u00edas","sequence":"additional","affiliation":[{"name":"Hospital Universitario Marqu\u00e9s de Valdecilla, Department of Internal Medicine, Santander, Spain"},{"name":"RETICEF, Instituto Carlos III, Barcelona, 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