{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T01:53:08Z","timestamp":1791078788270,"version":"4.1.0"},"reference-count":63,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2011,12,20]],"date-time":"2011-12-20T00:00:00Z","timestamp":1324339200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>In the treatment of postmenopausal osteoporosis (PMOP), the use of alendronate (ALN) leads to a decrease in the risk of vertebral and nonvertebral fractures. To explore the possible adverse effects of prolonged ALN therapy, we studied the effects of 8\u2009\u00b1\u20092 years (6\u201310 years) of ALN treatment on the iliac cortical bone mineral and collagen quality and micromechanical properties; by design, our study examined these parameters, independent of the degree of mineralization. From six ALN-treated and five age-matched untreated PMOP women, 153 bone structural units have been chosen according their degree of mineralization to obtain the same distribution in each group. In those bone structural units, Fourier transform infrared spectroscopy, quantitative microradiography, and nanoindentation were used to assess bone quality. Irrespective of the degree of mineralization, ALN treatment was associated with higher collagen maturity (+7%, p\u2009&amp;lt;\u20090.001, c.v.\u2009=\u200913% and 16% in treated and untreated women, respectively) and lower mineral crystallinity than that observed in the untreated PMOP group (\u22122%, p\u2009&amp;lt;\u20090.0001, c.v.\u2009=\u20093% in both groups). Bone matrix from ALN-treated women also had lower elastic modulus (\u221212%, p\u2009&amp;lt;\u20090.0001, c.v.\u2009=\u200914% in both groups) and, contact hardness (\u22126%, p\u2009&amp;lt;\u20090.05, c.v.\u2009=\u200914% in both groups) than that of untreated women. Crystallinity (which reflects the size and perfection of crystals) was associated with both elastic modulus and contact hardness in treated women exclusively (r\u2009=\u20090.43 and r\u2009=\u20090.54, p\u2009&amp;lt;\u20090.0001, respectively), even after adjustment for the amount of mineral. We infer that long-term ALN treatment compromises micromechanical properties of the bone matrix as assessed ex vivo. The strength deficits are in part related to difference in crystallinity, irrespective of the mineral amount and mineral maturity. These novel findings at local levels of bone structure will have to be taken into account in the study of the pathophysiology of bone fragilities associated with prolonged ALN treatment. \u00a9 2012 American Society for Bone and Mineral Research.<\/jats:p>","DOI":"10.1002\/jbmr.1501","type":"journal-article","created":{"date-parts":[[2011,12,20]],"date-time":"2011-12-20T17:05:33Z","timestamp":1324400733000},"page":"825-834","source":"Crossref","is-referenced-by-count":103,"title":["Bone micromechanical properties are compromised during long-term alendronate therapy independently of mineralization"],"prefix":"10.1093","volume":"27","author":[{"given":"Yohann","family":"Bala","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Lyon, F-69008 Lyon, France"},{"name":"INSERM, UMR1033, F-69372, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baptiste","family":"Depalle","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lyon, F-69008 Lyon, France"},{"name":"INSERM, UMR1033, F-69372, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delphine","family":"Farlay","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lyon, F-69008 Lyon, France"},{"name":"INSERM, UMR1033, F-69372, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Douillard","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lyon, CNRS, Villeurbanne, France"},{"name":"INSA Lyon, MATEIS UMR5510, F-69621 Villeurbanne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvain","family":"Meille","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lyon, CNRS, Villeurbanne, France"},{"name":"INSA Lyon, MATEIS UMR5510, F-69621 Villeurbanne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helene","family":"Follet","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lyon, F-69008 Lyon, France"},{"name":"INSERM, UMR1033, F-69372, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Chapurlat","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lyon, F-69008 Lyon, France"},{"name":"INSERM, UMR1033, F-69372, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me","family":"Chevalier","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lyon, CNRS, Villeurbanne, France"},{"name":"INSA Lyon, MATEIS UMR5510, F-69621 Villeurbanne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georges","family":"Boivin","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lyon, F-69008 Lyon, France"},{"name":"INSERM, UMR1033, F-69372, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,12,20]]},"reference":[{"issue":"2","key":"2024020318252778600_bib1","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/S1350-4533(98)00007-1","article-title":"Mechanical properties and the hierarchical structure of bone","volume":"20","author":"Rho","year":"1998","journal-title":"Med Eng Phys."},{"issue":"6","key":"2024020318252778600_bib2","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.berh.2005.07.004","article-title":"Determinants of skeletal fragility","volume":"19","author":"Bouxsein","year":"2005","journal-title":"Best Pract Res Clin Rheumatol."},{"issue":"21","key":"2024020318252778600_bib3","doi-asserted-by":"crossref","first-page":"2250","DOI":"10.1056\/NEJMra053077","article-title":"Bone quality\u2014the material and structural basis of bone strength and fragility","volume":"354","author":"Seeman","year":"2006","journal-title":"N Engl J Med."},{"key":"2024020318252778600_bib4","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/j.pmatsci.2007.06.001","article-title":"Nature's hierarchical materials","volume":"52","author":"Fratzl","year":"2007","journal-title":"Prog Mater Sci."},{"issue":"8","key":"2024020318252778600_bib5","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1007\/s11999-010-1706-9","article-title":"Functional interactions among morphologic and tissue quality traits define bone quality","volume":"469","author":"Jepsen","year":"2011","journal-title":"Clin Orthop Relat Res."},{"issue":"9727","key":"2024020318252778600_bib6","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1016\/S0140-6736(10)60320-0","article-title":"Intracortical remodelling and porosity in the distal radius and post-mortem femurs of women: a cross-sectional study","volume":"375","author":"Zebaze","year":"2010","journal-title":"Lancet."},{"issue":"9041","key":"2024020318252778600_bib7","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1016\/S0140-6736(96)07088-2","article-title":"Randomised trial of effect of alendronate on risk of fracture in women with existing vertebral fractures. 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