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Gr-1+CD11b+ myeloid-derived suppressor cells (MDSCs), overproduced in tumor-bearing hosts, contribute significantly to all these aspects. They also have a potential role in the osteolysis associated with bone metastases. They are formidable partners in tumor metastasis. \u00a9 2010 American Society for Bone and Mineral Research<\/jats:p>","DOI":"10.1002\/jbmr.154","type":"journal-article","created":{"date-parts":[[2010,6,22]],"date-time":"2010-06-22T18:09:58Z","timestamp":1277230198000},"page":"1701-1706","source":"Crossref","is-referenced-by-count":55,"title":["Gr-1+CD11b+ myeloid-derived suppressor cells: Formidable partners in tumor metastasis"],"prefix":"10.1093","volume":"25","author":[{"given":"Li","family":"Yang","sequence":"first","affiliation":[{"name":"Laboratory of Cancer Biology and Genetics, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, MD"},{"name":"Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire M","family":"Edwards","sequence":"additional","affiliation":[{"name":"Vanderbilt Center for Bone Biology, Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory R","family":"Mundy","sequence":"additional","affiliation":[{"name":"Vanderbilt Center for Bone Biology, Department of Medicine\/Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2010,7,30]]},"reference":[{"key":"2024020320114612000_bib1","doi-asserted-by":"crossref","first-page":"643","DOI":"10.2174\/1566524033479465","article-title":"Fundamental concepts of the angiogenic process","volume":"3","author":"Folkman","year":"2003","journal-title":"Curr Mol Med."},{"key":"2024020320114612000_bib2","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/nrd1381","article-title":"Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer","volume":"3","author":"Ferrara","year":"2004","journal-title":"Nat Rev Drug Discov."},{"key":"2024020320114612000_bib3","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/nm988","article-title":"Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer","volume":"10","author":"Willett","year":"2004","journal-title":"Nat Med."},{"key":"2024020320114612000_bib4","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/nrc2344","article-title":"Hypoxia and metabolism: hypoxia, DNA repair and genetic instability","volume":"8","author":"Bristow","year":"2008","journal-title":"Nat Rev Cancer."},{"key":"2024020320114612000_bib5","doi-asserted-by":"crossref","first-page":"3343","DOI":"10.1182\/blood-2007-10-115758","article-title":"HIF-1\u03b1 regulates epithelial inflammation by cell autonomous NF-\u03baB activation and paracrine stromal remodeling","volume":"111","author":"Scortegagna","year":"2008","journal-title":"Blood."},{"key":"2024020320114612000_bib6","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.ccr.2008.01.034","article-title":"HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion","volume":"13","author":"Du","year":"2008","journal-title":"Cancer Cell."},{"key":"2024020320114612000_bib7","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/431405a","article-title":"Cancer: an inflammatory link","volume":"431","author":"Balkwill","year":"2004","journal-title":"Nature."},{"key":"2024020320114612000_bib8","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/nature01322","article-title":"Inflammation and cancer","volume":"420","author":"Coussens","year":"2002","journal-title":"Nature."},{"key":"2024020320114612000_bib9","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.ccr.2007.12.004","article-title":"Abrogation of TGFbeta Signaling in Mammary Carcinomas Recruits Gr-1+CD11b+ Myeloid Cells that Promote Metastasis","volume":"13","author":"Yang","year":"2008","journal-title":"Cancer Cell."},{"key":"2024020320114612000_bib10","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.semcancer.2005.07.005","article-title":"Myeloid suppressor cells in cancer: Recruitment, phenotype, properties, and mechanisms of immune suppression","volume":"16","author":"Serafini","year":"2006","journal-title":"Semin Cancer Biol."},{"key":"2024020320114612000_bib11","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1126\/science.319.5860.154","article-title":"Cancer immunology. 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