{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T01:53:03Z","timestamp":1791078783002,"version":"4.1.0"},"reference-count":64,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2012,2,15]],"date-time":"2012-02-15T00:00:00Z","timestamp":1329264000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We used Raman and Fourier transform infrared microspectroscopy (FTIRM) analysis to examine the intrinsic bone material properties at actively bone-forming trabecular surfaces in iliac crest biopsies from women with postmenopausal osteoporosis (PMO) who were treated with either alendronate (ALN) or risedronate (RIS). At eight study sites, women were identified who had postmenopausal osteoporosis (PMO), were at least 5 years postmenopause, and had been on long-term therapy (either 3\u20135 years or &amp;gt;5 years) with daily or weekly ALN or RIS. Following standard tetracycline labeling, biopsies were collected from 102 women (33 treated with ALN for 3\u20135 years [ALN-3], 35 with ALN for &amp;gt;5 years [ALN-5], 26 with RIS for 3\u20135 years [RIS-3], and 8 with RIS for &amp;gt;5 years [RIS-5]) and were analyzed at anatomical areas of similar tissue age in bone-forming areas (within the fluorescent double labels). The following outcomes were monitored and reported: mineral to matrix ratio (corresponding to ash weight), relative proteoglycan content (regulating mineralization commencement), mineral maturity (indicative of the mineral crystallite chemistry and stoichiometry, and having a direct bearing on crystallite shape and size), and the ratio of two of the major enzymatic collagen cross-links (pyridinoline\/divalent). In RIS-5 there was a significant decrease in the relative proteoglycan content (\u22125.83% compared to ALN-5), while in both RIS-3 and RIS-5 there was significantly lower mineral maturity\/crystallinity (\u22126.78% and \u221213.68% versus ALN-3 and ALN-5, respectively), and pyridinoline\/divalent collagen cross-link ratio (\u221223.09% and \u221241.85% versus ALN-3 and ALN-5, respectively). The results of the present study indicate that ALN and RIS exert differential effects on the intrinsic bone material properties at actively bone-forming trabecular surfaces. \u00a9 2012 American Society for Bone and Mineral Research.<\/jats:p>","DOI":"10.1002\/jbmr.1572","type":"journal-article","created":{"date-parts":[[2012,2,15]],"date-time":"2012-02-15T20:50:47Z","timestamp":1329339047000},"page":"995-1003","source":"Crossref","is-referenced-by-count":36,"title":["Effects of alendronate and risedronate on bone material properties in actively forming trabecular bone surfaces"],"prefix":"10.1093","volume":"27","author":[{"given":"Birgit","family":"Hofstetter","sequence":"first","affiliation":[{"name":"Ludwig Boltzmann Institute of Osteology, Hanusch Hospital of WGKK and AUVA Trauma Centre Meidling, 1st Medical Department, Hanusch Hospital, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"Gamsjaeger","sequence":"additional","affiliation":[{"name":"Ludwig Boltzmann Institute of Osteology, Hanusch Hospital of WGKK and AUVA Trauma Centre Meidling, 1st Medical Department, Hanusch Hospital, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger J","family":"Phipps","sequence":"additional","affiliation":[{"name":"Husson University School of Pharmacy, Bangor, ME, USA."},{"name":"Warner Chilcott Ltd., Xerox Technology Park, Dundalk, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert R","family":"Recker","sequence":"additional","affiliation":[{"name":"Osteoporosis Research Center, Creighton University, Omaha, NE, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank H","family":"Ebetino","sequence":"additional","affiliation":[{"name":"Warner Chilcott Ltd., Xerox Technology Park, Dundalk, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Klaushofer","sequence":"additional","affiliation":[{"name":"Ludwig Boltzmann Institute of Osteology, Hanusch Hospital of WGKK and AUVA Trauma Centre Meidling, 1st Medical Department, Hanusch Hospital, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleftherios P","family":"Paschalis","sequence":"additional","affiliation":[{"name":"Ludwig Boltzmann Institute of Osteology, Hanusch Hospital of WGKK and AUVA Trauma Centre Meidling, 1st Medical Department, Hanusch Hospital, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2012,2,15]]},"reference":[{"issue":"5","key":"2024020318254652300_bib1","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.bone.2005.05.003","article-title":"Novel insights into actions of bisphosphonates on bone: differences in interactions with hydroxyapatite","volume":"38","author":"Nancollas","year":"2006","journal-title":"Bone."},{"issue":"2","key":"2024020318254652300_bib2","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0022-3565(24)38786-5","article-title":"Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates","volume":"296","author":"Dunford","year":"2001","journal-title":"J Pharmacol Exp Ther."},{"issue":"20","key":"2024020318254652300_bib3","doi-asserted-by":"crossref","first-page":"7829","DOI":"10.1073\/pnas.0601643103","article-title":"The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs","volume":"103","author":"Kavanagh","year":"2006","journal-title":"Proc Natl Acad Sci U S A."},{"key":"2024020318254652300_bib4","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1196\/annals.1402.089","article-title":"Bisphosphonates: an update on mechanisms of action and how these relate to clinical efficacy","volume":"1117","author":"Russell","year":"2007","journal-title":"Ann N Y Acad Sci."},{"issue":"6","key":"2024020318254652300_bib5","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1172\/JCI119668","article-title":"Histomorphometric assessment of the long-term effects of alendronate on bone quality and remodeling in patients with osteoporosis","volume":"100","author":"Chavassieux","year":"1997","journal-title":"J Clin Invest."},{"issue":"5","key":"2024020318254652300_bib6","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/S8756-3282(02)00869-4","article-title":"Effects of long-term risedronate on bone quality and bone turnover in women with postmenopausal osteoporosis","volume":"31","author":"Eriksen","year":"2002","journal-title":"Bone."},{"issue":"6","key":"2024020318254652300_bib7","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/s00223-004-0039-7","article-title":"Five years of treatment with risedronate and its effects on bone safety in women with postmenopausal osteoporosis","volume":"75","author":"Ste-Marie","year":"2004","journal-title":"Calcif Tissue Int."},{"issue":"1","key":"2024020318254652300_bib8","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1359\/JBMR.040920","article-title":"Treatment with once-weekly alendronate 70mg compared with once-weekly risedronate 35mg in women with postmenopausal osteoporosis: a randomized double-blind study","volume":"20","author":"Rosen","year":"2005","journal-title":"J Bone Miner Res."},{"issue":"7","key":"2024020318254652300_bib9","doi-asserted-by":"crossref","first-page":"2631","DOI":"10.1210\/jc.2005-2602","article-title":"Comparison of weekly treatment of postmenopausal osteoporosis with alendronate versus risedronate over two years","volume":"91","author":"Bonnick","year":"2006","journal-title":"J Clin Endocrinol Metab."},{"key":"2024020318254652300_bib10","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1039\/B402005G","article-title":"Structure and mechanical quality of the collagen\u2013mineral nano-composite in bone","volume":"14","author":"Fratzl","year":"2004","journal-title":"J Mater Chem."},{"issue":"8","key":"2024020318254652300_bib11","doi-asserted-by":"crossref","first-page":"2170","DOI":"10.1007\/s11999-010-1751-4","article-title":"Infrared assessment of bone quality: a review","volume":"469","author":"Paschalis","year":"2011","journal-title":"Clin Orthop Relat Res."},{"issue":"5","key":"2024020318254652300_bib12","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1007\/s00198-008-0725-9","article-title":"Spectroscopic markers of bone quality in alendronate-treated postmenopausal women","volume":"20","author":"Boskey","year":"2009","journal-title":"Osteoporos Int."},{"issue":"10","key":"2024020318254652300_bib13","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1359\/jbmr.060701","article-title":"Bone material properties in trabecular bone from human iliac crest biopsies after 3- and 5-year treatment with risedronate","volume":"21","author":"Durchschlag","year":"2006","journal-title":"J Bone Miner Res."},{"issue":"1","key":"2024020318254652300_bib14","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1002\/jbmr.180","article-title":"Bone material properties in actively bone-forming trabeculae in postmenopausal women with osteoporosis after three years of treatment with once-yearly zoledronic acid","volume":"26","author":"Gamsjaeger","year":"2010","journal-title":"J Bone Miner Res."},{"key":"2024020318254652300_bib15","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1366\/000370203322554518","article-title":"Automated method for subtraction of fluorescence from biological Raman spectra","volume":"57","author":"Lieber","year":"2003","journal-title":"Appl Spectrosc."},{"key":"2024020318254652300_bib16","first-page":"227","volume-title":"Raman spectroscopy for soft matter applications","author":"Gamsj\u00e4ger","year":"2009"},{"issue":"9","key":"2024020318254652300_bib17","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1038\/nmat2505","article-title":"Comparative materials differences revealed in engineered bone as a function of cell-specific differentiation","volume":"8","author":"Gentleman","year":"2009","journal-title":"Nat Mater."},{"key":"2024020318254652300_bib18","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.bone.2010.04.608","article-title":"Cortical bone composition and orientation as a function of animal and tissue age in mice by Raman spectroscopy","volume":"47","author":"Gamsjaeger","year":"2010","journal-title":"Bone."},{"issue":"5","key":"2024020318254652300_bib19","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1007\/s00223-006-0011-9","article-title":"Complementary information on in vitro conversion of amorphous (precursor) calcium phosphate to hydroxyapatite from Raman microspectroscopy and wide-angle X-ray scattering","volume":"79","author":"Kazanci","year":"2006","journal-title":"Calcif Tissue Int."},{"issue":"3","key":"2024020318254652300_bib20","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.jsb.2006.06.011","article-title":"Bone osteonal tissues by Raman spectral mapping: orientation-composition","volume":"156","author":"Kazanci","year":"2006","journal-title":"J Struct Biol."},{"issue":"3","key":"2024020318254652300_bib21","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.bone.2007.04.200","article-title":"Raman imaging of two orthogonal planes within cortical bone","volume":"41","author":"Kazanci","year":"2007","journal-title":"Bone."},{"issue":"8","key":"2024020318254652300_bib22","doi-asserted-by":"crossref","first-page":"2160","DOI":"10.1007\/s11999-010-1692-y","article-title":"Raman Assessment of Bone Quality","volume":"469","author":"Morris","year":"2011","journal-title":"Clin Orthop Relat Res."},{"issue":"1","key":"2024020318254652300_bib23","first-page":"109","article-title":"Infrared microspectroscopic imaging of biomineralized tissues using a mercury-cadmium-telluride focal-plane array detector","volume":"44","author":"Marcott","year":"1998","journal-title":"Cell Mol Biol (Noisy-le-grand)."},{"issue":"10","key":"2024020318254652300_bib24","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1359\/jbmr.2001.16.10.1821","article-title":"Spectroscopic characterization of collagen cross-links in bone","volume":"16","author":"Paschalis","year":"2001","journal-title":"J Bone Miner Res."},{"issue":"6","key":"2024020318254652300_bib25","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1007\/s00198-009-0857-6","article-title":"Fourier transform infrared analysis and bone","volume":"20","author":"Paschalis","year":"2009","journal-title":"Osteoporos Int."},{"issue":"6","key":"2024020318254652300_bib26","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1359\/jbmr.080205","article-title":"Frequency and risk factors associated with osteonecrosis of the jaw in cancer patients treated with intravenous bisphosphonates","volume":"23","author":"Hoff","year":"2008","journal-title":"J Bone Miner Res."},{"issue":"10","key":"2024020318254652300_bib27","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1359\/jbmr.0707onj","article-title":"Bisphosphonate-associated osteonecrosis of the jaw: report of a task force of the American Society for Bone and Mineral Research","volume":"22","author":"Khosla","year":"2007","journal-title":"J Bone Miner Res."},{"issue":"10","key":"2024020318254652300_bib28","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1359\/jbmr.060712","article-title":"Osteonecrosis of the jaw: more research needed","volume":"21","author":"Shane","year":"2006","journal-title":"J Bone Miner Res."},{"issue":"11","key":"2024020318254652300_bib29","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.1002\/jbmr.253","article-title":"Atypical subtrochanteric and diaphyseal femoral fractures: Report of a task force of the American Society for Bone and Mineral Research","volume":"25","author":"Shane","year":"2010","journal-title":"J Bone Miner Res."},{"issue":"4","key":"2024020318254652300_bib30","first-page":"462","article-title":"The use of bisphosphonates in the treatment of osteoporosis","volume":"17","author":"Delmas","year":"2005","journal-title":"Curr Opin Rheumatol."},{"issue":"11","key":"2024020318254652300_bib31","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1007\/s00198-009-0893-2","article-title":"Risedronate dosing before breakfast compared with dosing later in the day in women with postmenopausal osteoporosis","volume":"20","author":"Kendler","year":"2009","journal-title":"Osteoporos Int."},{"issue":"10","key":"2024020318254652300_bib32","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1007\/s00198-007-0410-4","article-title":"Adherence to treatment of osteoporosis: a need for study","volume":"18","author":"Lekkerkerker","year":"2007","journal-title":"Osteoporos Int."},{"issue":"2","key":"2024020318254652300_bib33","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s00198-005-1957-6","article-title":"A new concept for bisphosphonate therapy: a rationale for the development of monthly oral dosing of ibandronate","volume":"17","author":"Reginster","year":"2006","journal-title":"Osteoporos Int."},{"issue":"6","key":"2024020318254652300_bib34","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1007\/s00198-008-0754-4","article-title":"Changes in non-enzymatic glycation and its association with altered mechanical properties following 1-year treatment with risedronate or alendronate","volume":"20","author":"Tang","year":"2009","journal-title":"Osteoporos Int."},{"issue":"3","key":"2024020318254652300_bib35","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.bone.2009.11.011","article-title":"Bisphosphonate treatment modifies canine bone mineral and matrix properties and their heterogeneity","volume":"46","author":"Gourion-Arsiquaud","year":"2010","journal-title":"Bone."},{"issue":"12","key":"2024020318254652300_bib36","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1007\/s00198-005-1992-3","article-title":"Comparison of mineral quality and quantity in iliac crest biopsies from high- and low-turnover osteoporosis: an FT-IR microspectroscopic investigation","volume":"16","author":"Boskey","year":"2005","journal-title":"Osteoporos Int."},{"issue":"11","key":"2024020318254652300_bib37","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.1359\/jbmr.2003.18.11.1942","article-title":"Distribution of collagen cross-links in normal human trabecular bone","volume":"18","author":"Paschalis","year":"2003","journal-title":"J Bone Miner Res."},{"issue":"12","key":"2024020318254652300_bib38","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1359\/jbmr.040820","article-title":"Bone fragility and collagen cross-links","volume":"19","author":"Paschalis","year":"2004","journal-title":"J Bone Miner Res."},{"key":"2024020318254652300_bib39","volume-title":"Atlas of orthopaedic pathology","author":"Bullough","year":"1992"},{"key":"2024020318254652300_bib40","first-page":"3","volume-title":"Osteoporosis","author":"Einhorn","year":"1996"},{"issue":"3","key":"2024020318254652300_bib41","first-page":"209","article-title":"Applications of Fourier transform infrared (FT-IR) microscopy to the study of mineralization in bone and cartilage","volume":"2","author":"Boskey","year":"1992","journal-title":"Cell Mater."},{"issue":"5","key":"2024020318254652300_bib42","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1007\/s00223-010-9404-x","article-title":"Contribution of mineral to bone structural behavior and tissue mechanical properties","volume":"87","author":"Donnelly","year":"2010","journal-title":"Calcif Tissue Int."},{"issue":"4","key":"2024020318254652300_bib43","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1007\/s002239900339","article-title":"Effects of bone CS-proteoglycans, DS-decorin, and DS-biglycan on hydroxyapatite formation in a gelatin gel","volume":"61","author":"Boskey","year":"1997","journal-title":"Calcif Tissue Int."},{"issue":"1","key":"2024020318254652300_bib44","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/S0006-291X(03)00693-4","article-title":"Decorin modulates matrix mineralization in vitro","volume":"305","author":"Mochida","year":"2003","journal-title":"Biochem Biophys Res Commun."},{"issue":"4","key":"2024020318254652300_bib45","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1002\/jbm.a.31599","article-title":"Bisphosphonate binding affinity as assessed by inhibition of carbonated apatite dissolution in vitro","volume":"85","author":"Henneman","year":"2008","journal-title":"J Biomed Mater Res A."},{"issue":"1","key":"2024020318254652300_bib46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.colsurfb.2006.03.016","article-title":"Surface functionalized titanium thin films: zeta-potential, protein adsorption and cell proliferation","volume":"50","author":"Cai","year":"2006","journal-title":"Colloids Surf B Biointerfaces."},{"issue":"10","key":"2024020318254652300_bib47","doi-asserted-by":"crossref","first-page":"105708","DOI":"10.1088\/0957-4484\/22\/10\/105708","article-title":"The role of surface charge on the uptake and biocompatibility of hydroxyapatite nanoparticles with osteoblast cells","volume":"22","author":"Chen","year":"2011","journal-title":"Nanotechnology."},{"issue":"5","key":"2024020318254652300_bib48","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.bioeng.2007.07.004","article-title":"Improved initial osteoblast functions on amino-functionalized titanium surfaces","volume":"24","author":"Nebe","year":"2007","journal-title":"Biomol Eng."},{"issue":"29","key":"2024020318254652300_bib49","doi-asserted-by":"crossref","first-page":"6218","DOI":"10.1039\/b902881a","article-title":"The positive influence of electrochemical cyclic potentiodynamic passivation (CPP) of a SS316LS surface on its response to fibronectin and pre-osteoblasts","volume":"11","author":"Shahryari","year":"2009","journal-title":"Phys Chem Chem Phys."},{"key":"2024020318254652300_bib50","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1746-160X-5-13","article-title":"A new biphasic osteoinductive calcium composite material with a negative Zeta potential for bone augmentation","volume":"5","author":"Smeets","year":"2009","journal-title":"Head Face Med."},{"issue":"3","key":"2024020318254652300_bib51","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1002\/jbm.a.30098","article-title":"Electrostatic interactions as a predictor for osteoblast attachment to biomaterials","volume":"70","author":"Smith","year":"2004","journal-title":"J Biomed Mater Res A."},{"issue":"8","key":"2024020318254652300_bib52","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1023\/B:JMSM.0000036270.68200.97","article-title":"Surface potential and osteoblast attraction to calcium phosphate compounds is affected by selected alkaline hydrolysis processing","volume":"15","author":"Smith","year":"2004","journal-title":"J Mater Sci Mater Med."},{"issue":"2","key":"2024020318254652300_bib53","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s10544-007-9139-2","article-title":"Zeta potential: a surface electrical characteristic to probe the interaction of nanoparticles with normal and cancer human breast epithelial cells","volume":"10","author":"Zhang","year":"2008","journal-title":"Biomed Microdevices."},{"issue":"10","key":"2024020318254652300_bib54","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1002\/jbmr.5650091006","article-title":"Abnormal bone mineralization after fluoride treatment in osteoporosis: a small-angle x-ray-scattering study","volume":"9","author":"Fratzl","year":"1994","journal-title":"J Bone Miner Res."},{"issue":"2","key":"2024020318254652300_bib55","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1002\/jbmr.5650110214","article-title":"Effects of sodium fluoride and alendronate on the bone mineral in minipigs: a small-angle X-ray scattering and backscattered electron imaging study","volume":"11","author":"Fratzl","year":"1996","journal-title":"J Bone Miner Res."},{"issue":"6","key":"2024020318254652300_bib56","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/s002239900372","article-title":"FTIR microspectroscopic analysis of human iliac crest biopsies from untreated osteoporotic bone","volume":"61","author":"Paschalis","year":"1997","journal-title":"Calcif Tissue Int."},{"issue":"8","key":"2024020318254652300_bib57","doi-asserted-by":"crossref","first-page":"4644","DOI":"10.1210\/jc.2004-2489","article-title":"Bone mineral and collagen quality in iliac crest biopsies of patients given teriparatide: new results from the fracture prevention trial","volume":"90","author":"Paschalis","year":"2005","journal-title":"J Clin Endocrinol Metab."},{"issue":"10","key":"2024020318254652300_bib58","doi-asserted-by":"crossref","first-page":"5597","DOI":"10.1073\/pnas.0631609100","article-title":"Materials become insensitive to flaws at nanoscale: lessons from nature","volume":"100","author":"Gao","year":"2003","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"47","key":"2024020318254652300_bib59","doi-asserted-by":"crossref","first-page":"17741","DOI":"10.1073\/pnas.0604237103","article-title":"Cooperative deformation of mineral and collagen in bone at the nanoscale","volume":"103","author":"Gupta","year":"2006","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"4","key":"2024020318254652300_bib60","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1016\/S0006-3495(00)76426-5","article-title":"Mineralized collagen fibrils: a mechanical model with a staggered arrangement of mineral particles","volume":"79","author":"Jager","year":"2000","journal-title":"Biophys J."},{"key":"2024020318254652300_bib61","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1016\/j.bone.2011.08.027","article-title":"Lathyrism-induced alterations in collagen cross-links influence the mechanical properties of bone material without affecting the mineral","volume":"49","author":"Paschalis","year":"2011","journal-title":"Bone."},{"key":"2024020318254652300_bib62","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1016\/j.bone.2011.08.015","article-title":"Effects of one year daily teriparatide treatment on trabecular bone material properties in postmenopausal osteoporotic women previously treated with alendronate or risedronate","volume":"49","author":"Gamsjaeger","year":"2011","journal-title":"Bone."},{"issue":"4","key":"2024020318254652300_bib63","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0002-9343(01)01124-X","article-title":"Improvement in spine bone density and reduction in risk of vertebral fractures during treatment with antiresorptive drugs","volume":"112","author":"Cummings","year":"2002","journal-title":"Am J Med."},{"issue":"3","key":"2024020318254652300_bib64","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1385\/JCD:7:3:255","article-title":"Relationship between changes in bone mineral density and vertebral fracture risk associated with risedronate: greater increases in bone mineral density do not relate to greater decreases in fracture risk","volume":"7","author":"Watts","year":"2004","journal-title":"J Clin Densitom."}],"container-title":["Journal of Bone and Mineral Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbmr.1572","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/27\/5\/995\/56560740\/1572_ftp.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/27\/5\/995\/56560740\/1572_ftp.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T21:55:40Z","timestamp":1742507740000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbmr\/article\/27\/5\/995-1003\/7598325"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2,15]]},"references-count":64,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2012,2,15]]},"published-print":{"date-parts":[[2012,5,1]]}},"URL":"https:\/\/doi.org\/10.1002\/jbmr.1572","relation":{},"ISSN":["0884-0431","1523-4681"],"issn-type":[{"value":"0884-0431","type":"print"},{"value":"1523-4681","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2012,5,1]]},"published":{"date-parts":[[2012,2,15]]}}}