{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,8]],"date-time":"2026-11-08T04:20:47Z","timestamp":1794111647546,"version":"4.8.0"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2012,3,9]],"date-time":"2012-03-09T00:00:00Z","timestamp":1331251200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Osteogenesis imperfecta (OI) is a hereditary disorder characterized by decreased biosynthesis or impaired morphology of type I collagen that leads to decreased bone mass and increased bone fragility. We hypothesized that patients with OI have altered bone microstructure and bone geometry. In this cross-sectional study we compared patients with type I OI to age- and gender-matched healthy controls. A total of 39 (13 men and 26 women) patients with OI, aged 53 (range, 21\u201377) years, and 39 controls, aged 53 (range, 21\u201377) years, were included in the study. Twenty-seven of the patients had been treated with bisphosphonates. High-resolution peripheral quantitative computed tomography (HR-pQCT) at the distal radius and distal tibia and dual-energy X-ray absorptiometry of total hip, femoral neck, trochanteric region, and the lumbar spine (L1\u2013L4) were performed. The patients were shorter than the controls (159\u2009\u00b1\u200910\u2009cm versus 170\u2009\u00b1\u20099\u2009cm, p\u2009&amp;lt;\u20090.001), but had similar body weight. In OI, areal bone mineral density (aBMD) was 8% lower at the hip (p\u2009&amp;lt;\u20090.05) and 13% lower at the spine (p\u2009&amp;lt;\u20090.001) compared with controls. The trabecular volumetric bone mineral density (vBMD) was 28% lower in radius (p\u2009&amp;lt;\u20090.001) and 38% lower in tibia (p\u2009&amp;lt;\u20090.001) in OI compared with controls. At radius, total bone area was 5% lower in OI than in controls (p\u2009&amp;lt;\u20090.05). In the tibia, cortical bone area was 18% lower in OI (p\u2009&amp;lt;\u20090.001). In both radius and tibia the number of trabeculae was lower in patients compared to the controls (35% and 38%, respectively, p\u2009&amp;lt;\u20090.001 at both sites). Furthermore, trabecular spacing was 55% higher in OI in both tibia and radius (p\u2009&amp;lt;\u20090.001 at both sites) when compared with controls. We conclude that patients with type I OI have lower aBMD, vBMD, bone area, and trabecular number when compared with healthy age- and gender-matched controls. \u00a9 2012 American Society for Bone and Mineral Research.<\/jats:p>","DOI":"10.1002\/jbmr.1592","type":"journal-article","created":{"date-parts":[[2012,3,9]],"date-time":"2012-03-09T14:06:38Z","timestamp":1331301998000},"page":"1405-1412","source":"Crossref","is-referenced-by-count":76,"title":["Bone geometry, density, and microarchitecture in the distal radius and tibia in adults with osteogenesis imperfecta type I assessed by high-resolution pQCT"],"prefix":"10.1093","volume":"27","author":[{"given":"Lars","family":"Folkestad","sequence":"first","affiliation":[{"name":"Institute of Clinical Research, University of Southern Denmark, Odense, Denmark"},{"name":"Department of Endocrinology, Hospital of Southwest Denmark, Esbjerg, Denmark"},{"name":"Department of Endocrinology, Odense University Hospital, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jannie Dahl","family":"Hald","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stinus","family":"Hansen","sequence":"additional","affiliation":[{"name":"Institute of Clinical Research, University of Southern Denmark, Odense, Denmark"},{"name":"Department of Endocrinology, Odense University Hospital, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeppe","family":"Gram","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Hospital of Southwest Denmark, Esbjerg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bente","family":"Langdahl","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Abrahamsen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Gentofte Hospital, Copenhagen, Denmark"},{"name":"Institute of Clinical Research, University of Southern Denmark, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Brixen","sequence":"additional","affiliation":[{"name":"Institute of Clinical Research, University of Southern Denmark, Odense, Denmark"},{"name":"Department of Endocrinology, Odense University Hospital, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2012,3,9]]},"reference":[{"issue":"1","key":"2024020318261953500_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejmg.2009.10.007","article-title":"Classification of Osteogenesis Imperfecta revisited","volume":"53","author":"Van Dijk","year":"2010","journal-title":"Eur J Med Genet."},{"key":"2024020318261953500_bib2","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1136\/jmg.16.2.101","article-title":"Genetic heterogeneity in OI","volume":"16","author":"Sillence","year":"1979","journal-title":"J Med Genet."},{"key":"2024020318261953500_bib3","doi-asserted-by":"crossref","first-page":"540178","DOI":"10.4061\/2011\/540178","article-title":"Genotype-phenotype correlations in autosomal dominant osteogenesis imperfecta","volume":"2011","author":"Ben Amor","year":"2011","journal-title":"J Osteoporos."},{"issue":"9","key":"2024020318261953500_bib4","first-page":"540","article-title":"New perspectives on osteogenesis imperfecta. 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