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It included 36 postmenopausal white women 50 years of age and older with normal or osteopenic BMD (T-scores better than \u22122.5 at the lumbar spine, proximal femur, and one-third radius on DXA). Eighteen women had a history of low-energy fracture, whereas 18 women had no history of fracture and served as an age, race, and ultradistal radius BMD-matched control group. A three-dimensional fast large-angle spin-echo (FLASE) sequence with 137\u2009\u00b5m\u2009\u00d7\u2009137\u2009\u00b5m\u2009\u00d7\u2009400\u2009\u00b5m resolution was performed through the nondominant wrist of all 36 women using the same 1.5T scanner. The high-resolution images were used to measure trabecular bone volume fraction, trabecular thickness, surface-to-curve ratio, and erosion index. Wilcoxon signed-rank tests were used to compare differences in BMD and \u00b5MRI parameters between postmenopausal women with and without fracture. Post-menopausal women with fracture had significantly lower (p\u2009&amp;lt;\u20090.05) trabecular bone volume fraction and surface-to-curve ratio and significantly higher (p\u2009&amp;lt;\u20090.05) erosion index than postmenopausal women without fracture. There was no significant difference between postmenopausal women with and without fracture in trabecular thickness (p\u2009=\u20090.80) and BMD of the spine (p\u2009=\u20090.21), proximal femur (p\u2009=\u20090.19), one-third radius (p\u2009=\u20090.47), and ultradistal radius (p\u2009=\u20090.90). Postmenopausal women with normal or osteopenic BMD who had a history of low-energy fracture had significantly different (p\u2009&amp;lt;\u20090.05) \u00b5MRI parameters than an age, race, and ultradistal radius BMD-matched control group of postmenopausal women with no history of fracture. Our study suggests that \u00b5MRI can be used to identify individuals without a DXA-based diagnosis of osteoporosis who have impaired trabecular microarchitecture and thus a heretofore-unappreciated elevated fracture risk. \u00a9 2012 American Society for Bone and Mineral Research.<\/jats:p>","DOI":"10.1002\/jbmr.1595","type":"journal-article","created":{"date-parts":[[2012,3,9]],"date-time":"2012-03-09T14:11:20Z","timestamp":1331302280000},"page":"1494-1500","source":"Crossref","is-referenced-by-count":28,"title":["Evaluation of trabecular microarchitecture in nonosteoporotic postmenopausal women with and without fracture"],"prefix":"10.1093","volume":"27","author":[{"given":"Richard","family":"Kijowski","sequence":"first","affiliation":[{"name":"Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Tuite","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane","family":"Kruger","sequence":"additional","affiliation":[{"name":"Osteoporosis Clinical Research Program, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Munoz Del Rio","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Kleerekoper","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, St. John River District Hospital, East China Township, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Binkley","sequence":"additional","affiliation":[{"name":"Osteoporosis Clinical Research Program, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2012,3,9]]},"reference":[{"key":"2024020318263743300_bib1","first-page":"785","article-title":"Osteoporosis prevention, diagnosis and therapy. 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