{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:28:56Z","timestamp":1791264536706,"version":"4.1.0"},"reference-count":91,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2012,6,15]],"date-time":"2012-06-15T00:00:00Z","timestamp":1339718400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Imbalances between bone resorption and formation lie at the root of disorders such as osteoporosis, Paget's disease of bone (PDB), and osteopetrosis. Recently, genetic and functional studies have implicated proteins involved in autophagic protein degradation as important mediators of bone cell function in normal physiology and in pathology. Autophagy is the conserved process whereby aggregated proteins, intracellular pathogens, and damaged organelles are degraded and recycled. This process is important both for normal cellular quality control and in response to environmental or internal stressors, particularly in terminally-differentiated cells. Autophagic structures can also act as hubs for the spatial organization of recycling and synthetic process in secretory cells. Alterations to autophagy (reduction, hyperactivation, or impairment) are associated with a number of disorders, including neurodegenerative diseases and cancers, and are now being implicated in maintenance of skeletal homoeostasis. Here, we introduce the topic of autophagy, describe the new findings that are starting to emerge from the bone field, and consider the therapeutic potential of modifying this pathway for the treatment of age-related bone disorders. \u00a9 2012 American Society for Bone and Mineral Research.<\/jats:p>","DOI":"10.1002\/jbmr.1668","type":"journal-article","created":{"date-parts":[[2012,6,15]],"date-time":"2012-06-15T17:19:29Z","timestamp":1339780769000},"page":"1439-1447","source":"Crossref","is-referenced-by-count":134,"title":["Autophagy: A new player in skeletal maintenance?"],"prefix":"10.1093","volume":"27","author":[{"given":"Lynne J","family":"Hocking","sequence":"first","affiliation":[{"name":"Musculoskeletal Research Programme, Division of Applied Medicine, University of Aberdeen, Aberdeen, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Whitehouse","sequence":"additional","affiliation":[{"name":"Department of Medical and Molecular Genetics, Kings College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miep H","family":"Helfrich","sequence":"additional","affiliation":[{"name":"Musculoskeletal Research Programme, Division of Applied Medicine, University of Aberdeen, Aberdeen, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2012,6,15]]},"reference":[{"key":"2024020318273042400_bib1","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1242\/jcs.063032","article-title":"Bone remodelling at a glance","volume":"124","author":"Crockett","year":"2011","journal-title":"J Cell Sci."},{"key":"2024020318273042400_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00198-010-1272-8","article-title":"New knowledge on critical osteoclast formation and activation pathways from study of rare genetic diseases of osteoclasts: focus on the RANK\/RANKL axis","volume":"22","author":"Crockett","year":"2011","journal-title":"Osteoporos Int."},{"key":"2024020318273042400_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.gene.2011.10.044","article-title":"Update on Wnt signaling in bone cell biology and bone disease","volume":"492","author":"Monroe","year":"2012","journal-title":"Gene."},{"key":"2024020318273042400_bib4","doi-asserted-by":"crossref","first-page":"391","DOI":"10.4161\/cc.8.3.7545","article-title":"Autophagy in mineralizing tissues: microenvironmental perspectives","volume":"8","author":"Srinivas","year":"2009","journal-title":"Cell Cycle."},{"key":"2024020318273042400_bib5","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/nrrheum.2011.109","article-title":"Autophagy and cartilage homeostasis mechanisms in joint health, aging and OA","volume":"7","author":"Lotz","year":"2011","journal-title":"Nat Rev Rheumatol."},{"key":"2024020318273042400_bib6","doi-asserted-by":"crossref","first-page":"a006734","DOI":"10.1101\/cshperspect.a006734","article-title":"Integration of clearance mechanisms: the proteasome and autophagy","volume":"2","author":"Wong","year":"2010","journal-title":"Cold Spring Harb Perspect Biol."},{"key":"2024020318273042400_bib7","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1016\/j.bbadis.2011.07.005","article-title":"Ip NY","volume":"1812","author":"Wong","year":"2011","journal-title":"Molecular machinery of macroautophagy and its deregulation in diseases. 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