{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:00:10Z","timestamp":1762866010926},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2012,8,22]],"date-time":"2012-08-22T00:00:00Z","timestamp":1345593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>A fracture in childhood is associated with low bone mineral density (BMD), but it is debated whether a fracture at growth also predicts low BMD in young adulthood. The purpose of this work was to gender-specifically evaluate whether children with a fracture are at increased risk of low BMD in young adulthood. Distal forearm BMD (g\/cm2) was measured with single-photon absorptiometry (SPA) in 47 boys and 26 girls (mean age 10 years, range 3\u201316 years) with an index fracture and in 41 boys and 43 girls (mean age 10 years, range 4\u201316 years) with no fracture. BMD was re-measured mean 27 years later with the same SPA apparatus and with dual-energy absorptiometry (DXA), quantitative ultrasound (QUS), and peripheral computed tomography (pQCT). Individual Z-scores were calculated using the control cohort as reference population. Data are presented as means with 95% confidence intervals (95% CI) within brackets and correlation with Pearson's correlation coefficient. Boys with an index fracture had at fracture event a distal forearm BMD Z-score of \u22120.4 (95% CI, \u22120.7 to \u22120.1) and at follow-up \u22120.4 (95% CI, \u22120.7 to \u22120.1). Corresponding values in girls were \u22120.2 (95% CI, \u22120.5 to 0.1) and \u22120.3 (95% CI, \u22120.7 to 0.1). The deficit in absolute bone mass was driven by men with index fractures in childhood due to low energy rather than moderate or high energy. There were no changes in BMD Z-score during the follow-up period. The BMD deficit at follow-up was in boys with an index fracture verified with all advocated techniques. A childhood fracture in men was associated with low BMD and smaller bone size in young adulthood whereas the deficit in women did not reach statistical significance. \u00a9 2013 American Society for Bone and Mineral Research.<\/jats:p>","DOI":"10.1002\/jbmr.1743","type":"journal-article","created":{"date-parts":[[2012,8,22]],"date-time":"2012-08-22T18:15:14Z","timestamp":1345659314000},"page":"351-359","source":"Crossref","is-referenced-by-count":26,"title":["Does a childhood fracture predict low bone mass in young adulthood?\u2014A 27-year prospective controlled study"],"prefix":"10.1093","volume":"28","author":[{"given":"Christian","family":"Buttazzoni","sequence":"first","affiliation":[{"name":"Clinical and Molecular Osteoporosis Research Unit, Department of Clinical Sciences and Orthopaedics, Lund University, Sk\u00e5ne University Hospital, SE-205 02 Malmo, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bjorn E","family":"Rosengren","sequence":"additional","affiliation":[{"name":"Clinical and Molecular Osteoporosis Research Unit, Department of Clinical Sciences and Orthopaedics, Lund University, Sk\u00e5ne University Hospital, SE-205 02 Malmo, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magnus","family":"Tveit","sequence":"additional","affiliation":[{"name":"Clinical and Molecular Osteoporosis Research Unit, Department of Clinical Sciences and Orthopaedics, Lund University, Sk\u00e5ne University Hospital, SE-205 02 Malmo, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lennart","family":"Landin","sequence":"additional","affiliation":[{"name":"Clinical and Molecular Osteoporosis Research Unit, Department of Clinical Sciences and Orthopaedics, Lund University, Sk\u00e5ne University Hospital, SE-205 02 Malmo, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan-\u00c5ke","family":"Nilsson","sequence":"additional","affiliation":[{"name":"Clinical and Molecular Osteoporosis Research Unit, Department of Clinical Sciences and Orthopaedics, Lund University, Sk\u00e5ne University Hospital, SE-205 02 Malmo, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magnus K","family":"Karlsson","sequence":"additional","affiliation":[{"name":"Clinical and Molecular Osteoporosis Research Unit, Department of Clinical Sciences and Orthopaedics, Lund University, Sk\u00e5ne University Hospital, SE-205 02 Malmo, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2012,8,22]]},"reference":[{"issue":"6","key":"2024020318433632800_bib1","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1359\/jbmr.070315","article-title":"Residual lifetime risk of fractures in women and men","volume":"22","author":"Nguyen","year":"2007","journal-title":"J Bone Miner Res."},{"issue":"12","key":"2024020318433632800_bib2","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1007\/s001980200137","article-title":"How many children remain fracture-free during growth? A longitudinal study of children and adolescents participating in the Dunedin Multidisciplinary Health and Development Study","volume":"13","author":"Jones","year":"2002","journal-title":"Osteoporos Int."},{"key":"2024020318433632800_bib3","first-page":"1","article-title":"Fracture patterns in children: analysis of 8,682 fractures with special reference to incidence, etiology and secular changes in a Swedish urban population 1950\u20131979","volume":"202","author":"Landin","year":"1983","journal-title":"Acta Orthop Scand Suppl."},{"issue":"2","key":"2024020318433632800_bib4","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1097\/01202412-199704000-00002","article-title":"Epidemiology of children's fractures","volume":"6","author":"Landin","year":"1997","journal-title":"J Pediatr Orthop B."},{"issue":"7041","key":"2024020318433632800_bib5","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1136\/bmj.312.7041.1254","article-title":"Meta-analysis of how well measures of bone mineral density predict occurrence of osteoporotic fractures","volume":"312","author":"Marshall","year":"1996","journal-title":"BMJ."},{"issue":"7","key":"2024020318433632800_bib6","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1359\/JBMR.050304","article-title":"Predictive value of BMD for hip and other fractures","volume":"20","author":"Johnell","year":"2005","journal-title":"J Bone Miner Res. Jul."},{"issue":"2","key":"2024020318433632800_bib7","doi-asserted-by":"crossref","first-page":"e291","DOI":"10.1542\/peds.2005-1404","article-title":"Association between bone density and fractures in children: a systematic review and meta-analysis","volume":"117","author":"Clark","year":"2006","journal-title":"Pediatrics."},{"issue":"9","key":"2024020318433632800_bib8","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1359\/jbmr.060601","article-title":"Association between bone mass and fractures in children: a prospective cohort study","volume":"21","author":"Clark","year":"2006","journal-title":"J Bone Miner Res."},{"issue":"1","key":"2024020318433632800_bib9","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1359\/jbmr.1998.13.1.143","article-title":"Bone mineral density in girls with forearm fractures","volume":"13","author":"Goulding","year":"1998","journal-title":"J Bone Miner Res."},{"issue":"1046","key":"2024020318433632800_bib10","first-page":"232","article-title":"Women with past history of bone fracture have low spinal bone density before menopause","volume":"110","author":"Goulding","year":"1997","journal-title":"N Z Med J."},{"issue":"12","key":"2024020318433632800_bib11","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1359\/JBMR.050820","article-title":"Bone and body composition of children and adolescents with repeated forearm fractures","volume":"20","author":"Goulding","year":"2005","journal-title":"J Bone Miner Res."},{"issue":"10","key":"2024020318433632800_bib12","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1359\/jbmr.2000.15.10.2011","article-title":"More broken bones: a 4-year double cohort study of young girls with and without distal forearm fractures","volume":"15","author":"Goulding","year":"2000","journal-title":"J Bone Miner Res."},{"key":"2024020318433632800_bib13","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1097\/00003086-198309000-00040","article-title":"Bone mineral content in children with fractures","volume":"(178)","author":"Landin","year":"1983","journal-title":"Clin Orthop Relat Res."},{"issue":"4","key":"2024020318433632800_bib14","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1210\/jc.2002-021682","article-title":"The association between bone mineral density, metacarpal morphometry, and upper limb fractures in children: a population-based case-control study","volume":"88","author":"Ma","year":"2003","journal-title":"J Clin Endocrinol Metab."},{"issue":"3","key":"2024020318433632800_bib15","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.bone.2006.03.018","article-title":"Fractures and recurrent fractures in children: varying effects of environmental factors as well as bone size and mass","volume":"39","author":"Manias","year":"2006","journal-title":"Bone."},{"issue":"10","key":"2024020318433632800_bib16","doi-asserted-by":"crossref","first-page":"3134","DOI":"10.1210\/jc.2011-1445","article-title":"Fractures during childhood and adolescence in healthy boys: relation with bone mass, microstructure, and strength","volume":"96","author":"Chevalley","year":"2011","journal-title":"J Clin Endocrinol Metab."},{"issue":"4","key":"2024020318433632800_bib17","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1056\/NEJMoa022464","article-title":"Bone loss and bone size after menopause","volume":"349","author":"Ahlborg","year":"2003","journal-title":"N Engl J Med."},{"issue":"7","key":"2024020318433632800_bib18","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1359\/JBMR.050306","article-title":"Age of attainment of peak bone mass is site specific in Swedish men\u2014The GOOD study","volume":"20","author":"Lorentzon","year":"2005","journal-title":"J Bone Miner Res."},{"issue":"1","key":"2024020318433632800_bib19","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1007\/BF01880413","article-title":"The contribution of bone loss to postmenopausal osteoporosis","volume":"1","author":"Hui","year":"1990","journal-title":"Osteoporos Int."},{"issue":"3","key":"2024020318433632800_bib20","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1530\/eje.0.1330265","article-title":"Genetic influences on bone turnover, bone density and fracture","volume":"133","author":"Kelly","year":"1995","journal-title":"Eur J Endocrinol."},{"issue":"10","key":"2024020318433632800_bib21","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1359\/jbmr.1999.14.10.1672","article-title":"A six-year longitudinal study of the relationship of physical activity to bone mineral accrual in growing children: the university of Saskatchewan bone mineral accrual study","volume":"14","author":"Bailey","year":"1999","journal-title":"J Bone Miner Res."},{"issue":"3","key":"2024020318433632800_bib22","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/8756-3282(95)00151-3","article-title":"Bone mineral density in female athletes representing sports with different loading characteristics of the skeleton","volume":"17","author":"Heinonen","year":"1995","journal-title":"Bone."},{"issue":"9202","key":"2024020318433632800_bib23","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/S0140-6736(00)82020-6","article-title":"Exercise during growth and bone mineral density and fractures in old age","volume":"355","author":"Karlsson","year":"2000","journal-title":"Lancet."},{"issue":"9","key":"2024020318433632800_bib24","doi-asserted-by":"crossref","first-page":"3177","DOI":"10.1210\/jcem.85.9.6796","article-title":"Bone size and volumetric density in women with anorexia nervosa receiving estrogen replacement therapy and in women recovered from anorexia nervosa","volume":"85","author":"Karlsson","year":"2000","journal-title":"J Clin Endocrinol Metab."},{"issue":"11","key":"2024020318433632800_bib25","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.1359\/jbmr.2000.15.11.2259","article-title":"On exposure to anorexia nervosa, the temporal variation in axial and appendicular skeletal development predisposes to site-specific deficits in bone size and density: a cross-sectional study","volume":"15","author":"Seeman","year":"2000","journal-title":"J Bone Miner Res."},{"issue":"2","key":"2024020318433632800_bib26","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1359\/jbmr.071010","article-title":"Bone fragility contributes to the risk of fracture in children, even after moderate and severe trauma","volume":"23","author":"Clark","year":"2008","journal-title":"J Bone Miner Res."},{"issue":"12","key":"2024020318433632800_bib27","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1359\/jbmr.060907","article-title":"Size-corrected BMD decreases during peak linear growth: implications for fracture incidence during adolescence","volume":"21","author":"Faulkner","year":"2006","journal-title":"J Bone Miner Res."},{"issue":"6","key":"2024020318433632800_bib28","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1359\/jbmr.2002.17.6.1065","article-title":"Four-year gain in bone mineral in girls with and without past forearm fractures: a DXA study. Dual energy X-ray absorptiometry","volume":"17","author":"Jones","year":"2002","journal-title":"J Bone Miner Res."},{"issue":"8","key":"2024020318433632800_bib29","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1002\/jbmr.412","article-title":"Bone mineral accrual from 8 to 30 years of age: an estimation of peak bone mass","volume":"26","author":"Baxter-Jones","year":"2011","journal-title":"J Bone Miner Res."},{"issue":"17","key":"2024020318433632800_bib30","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.1001\/jama.1992.03490170075028","article-title":"Bone gain in young adult women","volume":"268","author":"Recker","year":"1992","journal-title":"JAMA."},{"issue":"4","key":"2024020318433632800_bib31","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1359\/jbmr.051215","article-title":"Childhood fractures are associated with decreased bone mass gain during puberty: an early marker of persistent bone fragility?","volume":"21","author":"Ferrari","year":"2006","journal-title":"J Bone Miner Res."},{"key":"2024020318433632800_bib32","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1359\/jbmr.060304","article-title":"A school-curriculum-based exercise intervention program for two years in pre-pubertal girls does not influence hip structure","volume":"21","author":"Linden","year":"2006","journal-title":"J Bone Miner Res."},{"issue":"6 Suppl 1","key":"2024020318433632800_bib33","doi-asserted-by":"crossref","first-page":"S47","DOI":"10.1016\/j.bone.2007.04.052","article-title":"Characteristics of children experiencing incident fractures: an 8-year longitudinal DXA study of 142 New Zealand girls","volume":"40","author":"Goulding","year":"2007","journal-title":"Bone."},{"issue":"4","key":"2024020318433632800_bib34","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1359\/jbmr.2000.15.4.721","article-title":"Patients with prior fractures have an increased risk of future fractures: a summary of the literature and statistical synthesis","volume":"15","author":"Klotzbuecher","year":"2000","journal-title":"J Bone Miner Res."},{"issue":"7","key":"2024020318433632800_bib35","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1359\/jbmr.090220","article-title":"Childhood fractures do not predict future fractures: results from the European Prospective Osteoporosis Study","volume":"24","author":"Pye","year":"2009","journal-title":"J Bone Miner Res."},{"issue":"2","key":"2024020318433632800_bib36","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.bone.2009.10.003","article-title":"Peak bone mineral density, lean body mass and fractures","volume":"46","author":"Boot","year":"2010","journal-title":"Bone."}],"container-title":["Journal of Bone and Mineral Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbmr.1743","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/28\/2\/351\/56563139\/1743_ftp.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/28\/2\/351\/56563139\/1743_ftp.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T14:47:44Z","timestamp":1710341264000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbmr\/article\/28\/2\/351-359\/7598631"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,22]]},"references-count":36,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2012,8,22]]},"published-print":{"date-parts":[[2013,2,1]]}},"URL":"https:\/\/doi.org\/10.1002\/jbmr.1743","relation":{},"ISSN":["0884-0431","1523-4681"],"issn-type":[{"value":"0884-0431","type":"print"},{"value":"1523-4681","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2013,2,1]]},"published":{"date-parts":[[2012,8,22]]}}}