{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:51:50Z","timestamp":1791417110370,"version":"4.3.3"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2012,9,18]],"date-time":"2012-09-18T00:00:00Z","timestamp":1347926400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Androgen deprivation therapy (ADT), a treatment for prostate cancer, is associated with bone loss and fractures. Dual-energy X-ray absorptiometry (DXA)\u2013measured bone mineral density does not assess vertebral fractures (VF). High-resolution micro-magnetic resonance imaging (HR-MRI) assesses bone microarchitecture and provides structural information. To determine if VF identification increased the diagnosis of osteoporosis beyond DXA and if HR-MRI demonstrated skeletal deterioration in men with VF, we cross-sectionally studied 137 men aged\u2009\u2265\u200960 years with nonmetastatic prostate cancer on ADT for\u2009\u2265\u20096 months. Vertebral fracture assessment (VFA) by DXA was confirmed with X-rays. HR-MRI of the wrist included bone volume to total volume (BV\/TV), surface density (trabecular plates), surface\/curve ratio (plates\/rods), and erosion index (higher depicts deterioration). VF were found in 37% of men; the majority were unknown. Seven percent of participants were classified as osteoporotic by hip or spine DXA. Thirty-seven percent of men without osteoporosis by DXA had VF identified, suggesting that 90% of patients with clinical osteoporosis would have been misclassified by DXA alone. By ANOVA comparison across VF grades, the BV\/TV, surface density, and spine, hip, and wrist DXA were lower, and erosion index was higher in men with moderate-severe VF compared with lesser grades (all p\u2009&amp;lt;\u20090.05). By unadjusted ROC analysis, the addition of HR-MRI to DXA at the spine, hip, and femoral neck added substantially (AUC increased 0.831 to 0.902, p\u2009&amp;lt;\u20090.05) to prediction of moderate-severe vertebral fracture. HR-MRI indices were associated with spine, hip, and wrist DXA measures (p\u2009&amp;lt;\u20090.01). Longer duration of ADT was associated with lower BV\/TV, surface density, and surface\/curve ratio (p\u2009&amp;lt;\u20090.05). ADT for men with prostate cancer is associated with silent VF. DXA alone leads to misclassifications of osteoporosis, which can be avoided by VF assessment. HR-MRI provides a novel technique to assess deterioration of structural integrity in men with VF and adds micro-structural information. \u00a9 2013 American Society for Bone and Mineral Research<\/jats:p>","DOI":"10.1002\/jbmr.1771","type":"journal-article","created":{"date-parts":[[2012,9,18]],"date-time":"2012-09-18T16:27:07Z","timestamp":1347985627000},"page":"325-332","source":"Crossref","is-referenced-by-count":45,"title":["Vertebral fractures and trabecular microstructure in men with prostate cancer on androgen deprivation therapy"],"prefix":"10.1093","volume":"28","author":[{"given":"Susan L","family":"Greenspan","sequence":"first","affiliation":[{"name":"Division of Endocrinology, University of Pittsburgh, Pittsburgh, PA,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Wagner","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, University of Pittsburgh, Pittsburgh, PA,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel B","family":"Nelson","sequence":"additional","affiliation":[{"name":"Department of Urology, University of Pittsburgh Medical Center, Pittsburgh, PA,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subashan","family":"Perera","sequence":"additional","affiliation":[{"name":"Division of Geriatrics, University of Pittsburgh, Pittsburgh, PA,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Britton","sequence":"additional","affiliation":[{"name":"Division of Radiology, University of Pittsburgh, Pittsburgh, PA,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil M","family":"Resnick","sequence":"additional","affiliation":[{"name":"Division of Geriatrics, University of Pittsburgh, Pittsburgh, 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