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We describe a novel use of Cinacalcet to treat a child with HVDRR in whom conventional modes of therapy had to be discontinued. Cinacalcet therapy with high-dose oral calcium effectively normalized the metabolic abnormalities and bone condition. The relative ease of administration of the calcimimetic as a once- or twice-daily oral preparation, compared with traditional intravenous calcium administration, should encourage its move to the frontline of treatment of the disorder. \u00a9 2013 American Society for Bone and Mineral Research.<\/jats:p>","DOI":"10.1002\/jbmr.1838","type":"journal-article","created":{"date-parts":[[2012,12,4]],"date-time":"2012-12-04T21:11:36Z","timestamp":1354655496000},"page":"992-996","source":"Crossref","is-referenced-by-count":18,"title":["Cinacalcet as adjunctive therapy for hereditary 1,25-dihydroxyvitamin D\u2013resistant rickets"],"prefix":"10.1093","volume":"28","author":[{"given":"Tarak","family":"Srivastava","sequence":"first","affiliation":[{"name":"Section of Nephrology, Bone and Mineral Disorder Clinic, Children's Mercy Hospitals and Clinics, University of Missouri at Kansas City, Kansas City, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uri S","family":"Alon","sequence":"additional","affiliation":[{"name":"Section of Nephrology, Bone and Mineral Disorder Clinic, Children's Mercy Hospitals and Clinics, University of Missouri at Kansas City, Kansas City, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2012,12,4]]},"reference":[{"key":"2024020318394933600_bib1","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.ecl.2010.02.004","article-title":"Genetic disorders and defects in vitamin D action","volume":"39","author":"Malloy","year":"2010","journal-title":"Endocrinol Metab Clin North Am."},{"key":"2024020318394933600_bib2","first-page":"156","article-title":"The vitamin D receptor and the syndrome of hereditary 1,25-dihydroxyvitamin D-resistant rickets","volume":"20","author":"Malloy","year":"1999","journal-title":"Endocr Rev."},{"key":"2024020318394933600_bib3","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1016\/B978-012252687-9\/50075-9","volume-title":"Vitamin D","author":"Malloy","year":"2005","edition":"2nd ed"},{"key":"2024020318394933600_bib4","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1016\/0002-9343(87)90666-8","article-title":"Long-term intracaval calcium infusion therapy in end-organ resistance to 1,25-dihydroxyvitamin D","volume":"83","author":"Weisman","year":"1987","journal-title":"Am J Med."},{"key":"2024020318394933600_bib5","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1172\/JCI112483","article-title":"Long-term nocturnal calcium infusions can cure rickets and promote normal mineralization in hereditary resistance to 1,25-dihydroxyvitamin D","volume":"77","author":"Balsan","year":"1986","journal-title":"J Clin Invest."},{"key":"2024020318394933600_bib6","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/j.1365-2265.1993.tb01779.x","article-title":"The combined use of intravenous and oral calcium for the treatment of vitamin D dependent rickets type II (VDDRII)","volume":"39","author":"al-Aqeel","year":"1993","journal-title":"Clin Endocrinol (Oxf)."},{"key":"2024020318394933600_bib7","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/S0022-3476(05)81919-5","article-title":"Calcium therapy for calcitriol-resistant rickets","volume":"121","author":"Hochberg","year":"1992","journal-title":"J Pediatr."},{"key":"2024020318394933600_bib8","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1007\/s00774-009-0079-1","article-title":"Hypophosphatemia: the common denominator of all rickets","volume":"27","author":"Tiosano","year":"2009","journal-title":"J Bone Miner Metab."},{"key":"2024020318394933600_bib9","doi-asserted-by":"crossref","first-page":"658","DOI":"10.2215\/CJN.04981107","article-title":"Calcimimetics as an adjuvant treatment for familial hypophosphatemic rickets. 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