{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T09:31:09Z","timestamp":1773221469357,"version":"3.50.1"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2012,12,13]],"date-time":"2012-12-13T00:00:00Z","timestamp":1355356800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Subjects with inflammatory bowel disease (IBD) are at increased risk for hip and other major osteoporotic fractures. However, previous analyses have not fully accounted for differences in bone mineral density (BMD) and other clinical factors that affect the risk of fracture. The World Health Organization Fracture Risk Assessment tool (FRAX) can be used to predict the 10-year fracture risk from BMD and clinical risk factors. A population-based database containing clinical information on all IBD subjects in the province of Manitoba, Canada, was linked with the Manitoba Bone Mineral Density Database, which contains results of all dual X-ray absorptiometry (DXA) scans in the province. FRAX probabilities were calculated for all subjects aged 50 years or more undergoing baseline DXA testing. Subjects were followed for occurrence of major osteoporotic fractures (MOF; hip, clinical spine, wrist, humerus). Cox proportional hazards models were used to determine whether IBD was independently predictive of MOF or hip fracture. After controlling for FRAX fracture probability computed with BMD, IBD was not associated with a significantly increased risk for MOF (hazard ratio [HR]\u2009=\u20091.12, 95% confidence interval [CI], 0.83\u20131.55) but was associated with an increased risk for hip fracture (HR\u2009=\u20092.14; 95% CI, 1.26\u20133.65). The addition of femoral neck T-score to FRAX probability without knowledge of BMD had a negligible effect on the estimated HRs for IBD, suggesting that IBD mediates any effect on fracture risk independently of femoral neck BMD. After controlling for FRAX probability, subjects with IBD are not at an increased risk for overall MOF, but may be at increased risk of hip fracture. \u00a9 2013 American Society for Bone and Mineral Research.<\/jats:p>","DOI":"10.1002\/jbmr.1848","type":"journal-article","created":{"date-parts":[[2012,12,13]],"date-time":"2012-12-13T15:01:58Z","timestamp":1355410918000},"page":"1007-1013","source":"Crossref","is-referenced-by-count":26,"title":["Inflammatory bowel disease and the risk of fracture after controlling for FRAX"],"prefix":"10.1093","volume":"28","author":[{"given":"Laura E","family":"Targownik","sequence":"first","affiliation":[{"name":"University of Manitoba IBD Clinical and Research Centre, Winnipeg, Manitoba, Canada"},{"name":"Section of Gastroenterology, Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles N","family":"Bernstein","sequence":"additional","affiliation":[{"name":"University of Manitoba IBD Clinical and Research Centre, Winnipeg, Manitoba, Canada"},{"name":"Section of Gastroenterology, Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zoann","family":"Nugent","sequence":"additional","affiliation":[{"name":"Cancercare Manitoba, Winnipeg, Manitoba, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helena","family":"Johansson","sequence":"additional","affiliation":[{"name":"WHO Collaborating Centre for Metabolic Bone Diseases, University of Sheffield, Sheffield, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"Oden","sequence":"additional","affiliation":[{"name":"WHO Collaborating Centre for Metabolic Bone Diseases, University of Sheffield, Sheffield, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugene","family":"McCloskey","sequence":"additional","affiliation":[{"name":"Osteoporosis Centre, Northern General Hospital, Sheffield, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John A","family":"Kanis","sequence":"additional","affiliation":[{"name":"WHO Collaborating Centre for Metabolic Bone Diseases, University of Sheffield, Sheffield, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William D","family":"Leslie","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Manitoba, Winnipeg, Manitoba, Canada"},{"name":"Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2012,12,13]]},"reference":[{"issue":"7","key":"2024020318393269500_bib1","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1359\/JBMR.050304","article-title":"Predictive value of BMD for hip and other fractures","volume":"20","author":"Johnell","year":"2005","journal-title":"J Bone Miner Res."},{"issue":"6","key":"2024020318393269500_bib2","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1503\/cmaj.070234","article-title":"Low bone mineral density and fracture burden in postmenopausal women","volume":"177","author":"Cranney","year":"2007","journal-title":"CMAJ."},{"issue":"7041","key":"2024020318393269500_bib3","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1136\/bmj.312.7041.1254","article-title":"Meta-analysis of how well measures of bone mineral density predict occurrence of osteoporotic fractures","volume":"312","author":"Marshall","year":"1996","journal-title":"BMJ."},{"issue":"11","key":"2024020318393269500_bib4","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1359\/jbmr.2003.18.11.1947","article-title":"Osteoporotic Fractures Research Group. 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