{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T04:47:53Z","timestamp":1790484473632,"version":"4.1.0"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2013,1,15]],"date-time":"2013-01-15T00:00:00Z","timestamp":1358208000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,6,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>\u2003<\/jats:title>\n                  <jats:p>Mechanical unloading, such as in a microgravity environment in space or during bed rest (for patients who require prolonged bed rest), leads to a decrease in bone mass because of the suppression of bone formation and the stimulation of bone resorption. To address the challenges presented by a prolonged stay in space and the forthcoming era of a super-aged society, it will be important to prevent the bone loss caused by prolonged mechanical unloading. Nuclear factor \u03baB (NF-\u03baB) transcription factors are activated by mechanical loading and inflammatory cytokines. Our objective was to elucidate the role of NF-\u03baB pathways in bone loss that are caused by mechanical unloading. Eight-week-old wild-type (WT) and NF-\u03baB1-deficient mice were randomly assigned to a control or mechanically unloaded with tail suspension group. After 2 weeks, a radiographic analysis indicated a decrease in bone mass in the tibias and femurs of the unloaded WT mice but not in the NF-\u03baB1\u2013deficient mice. An NF-\u03baB1 deficiency suppressed the unloading-induced reduction in bone formation by maintaining the proportion and\/or potential of osteoprogenitors or immature osteoblasts, and by suppression of bone resorption through the inhibition of intracellular signaling through the receptor activator of NF-\u03baB ligand (RANKL) in osteoclast precursors. Thus, NF-\u03baB1 is involved in two aspects of rapid reduction in bone mass that are induced by disuse osteoporosis in space or bed rest.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/jbmr.1866","type":"journal-article","created":{"date-parts":[[2013,1,15]],"date-time":"2013-01-15T17:12:39Z","timestamp":1358269959000},"page":"1457-1467","source":"Crossref","is-referenced-by-count":41,"title":["Disruption of NF-\u03baB1 prevents bone loss caused by mechanical unloading"],"prefix":"10.1093","volume":"28","author":[{"given":"Hitomi","family":"Nakamura","sequence":"first","affiliation":[{"name":"Division of Developmental Stomatognathic Function ScienceDepartment of Health ImprovementKyushu Dental UniversityFukuokaJapan"},{"name":"Division of Molecular Signaling and BiochemistryDepartment of Health ImprovementKyushu Dental 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