{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T04:36:31Z","timestamp":1772858191910,"version":"3.50.1"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2013,3,2]],"date-time":"2013-03-02T00:00:00Z","timestamp":1362182400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,8,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>\u2003<\/jats:title>\n                  <jats:p>Distal forearm fractures are among the most common fractures during childhood, but it remains unclear whether they predict an increased fracture risk later in life. We studied a population-based cohort of 1776 children \u226418 years of age, from Olmsted County, MN, USA, who had a distal forearm fracture in 1935\u20131992. Incident fractures occurring at age \u226535 years were identified through review of complete medical records using the linkage system of the Rochester Epidemiology Project. Observed nonpathologic fractures resulting from no more than moderate trauma (fragility fractures) were compared with expected numbers estimated from fracture site\u2013specific incidence rates, based on age, sex, and calendar year, for Olmsted County (standardized incidence ratios [SIR]). In 1086 boys (mean\u2009\u00b1\u2009SD age; 11\u2009\u00b1\u20094 years) and 690 girls (10\u2009\u00b1\u20094 years) followed for 27,292 person-years after the age of 35 years, subsequent fragility fractures were observed in 144 (13%) men and 74 (11%) women. There was an increased risk for future fragility fractures in boys who had a distal forearm fracture (SIR, 1.9; 95% CI, 1.6\u20132.3) but not girls (SIR, 1.0; 95% CI, 0.8\u20131.2). Fragility fractures at both major osteoporotic (hip, spine, wrist, and shoulder) sites (SIR, 2.6; 95% CI, 2.1\u20133.3) and remaining sites (SIR, 1.7; 95% CI, 1.3\u20132.0) were increased in men, irrespective of age at distal forearm fracture as boys. A distal forearm fracture in boys, but not girls, is associated with an increased risk for fragility fractures as older adults. It is necessary to determine whether the increased fractures observed in men is due to persistent deficits of bone strength, continued high fracture risk activity, or both. Until then, men should be asked about a childhood distal forearm fracture and, if so, warrant further screening and counseling on measures to optimize bone health and prevent fractures.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/jbmr.1914","type":"journal-article","created":{"date-parts":[[2013,3,3]],"date-time":"2013-03-03T04:22:14Z","timestamp":1362284534000},"page":"1751-1759","source":"Crossref","is-referenced-by-count":39,"title":["A distal forearm fracture in childhood is associated with an increased risk for future fragility fractures in adult men, but not women"],"prefix":"10.1093","volume":"28","author":[{"given":"Shreyasee","family":"Amin","sequence":"first","affiliation":[{"name":"Division of Epidemiology, Department of Health Sciences ResearchCollege of Medicine, Mayo ClinicRochesterMNUSA"},{"name":"Division of Rheumatology, Department of Internal MedicineCollege of Medicine, Mayo ClinicRochesterMNUSA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"III","given":"L Joseph","family":"Melton","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, Department of Health Sciences ResearchCollege of Medicine, Mayo ClinicRochesterMNUSA"},{"name":"Division of Endocrinology, Metabolism and Nutrition, Department of Internal MedicineCollege of Medicine, Mayo ClinicRochesterMNUSA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara J","family":"Achenbach","sequence":"additional","affiliation":[{"name":"Division of Biomedical Statistics and Informatics, Department of Health Sciences ResearchCollege of Medicine, Mayo ClinicRochesterMNUSA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth J","family":"Atkinson","sequence":"additional","affiliation":[{"name":"Division of Biomedical Statistics and Informatics, Department of Health Sciences ResearchCollege of Medicine, Mayo ClinicRochesterMNUSA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark B","family":"Dekutoski","sequence":"additional","affiliation":[{"name":"Department of OrthopedicsCollege of Medicine, Mayo ClinicRochesterMNUSA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salman","family":"Kirmani","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Adolescent MedicineCollege of Medicine, Mayo ClinicRochesterMNUSA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip R","family":"Fischer","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Adolescent MedicineCollege of Medicine, Mayo ClinicRochesterMNUSA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sundeep","family":"Khosla","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Metabolism and Nutrition, Department of Internal MedicineCollege of Medicine, Mayo ClinicRochesterMNUSA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2013,3,2]]},"reference":[{"issue":"3","key":"2024020318363606500_jbmr1914-bib-0001","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s00198-005-2039-5","article-title":"Review: developmental origins of osteoporotic fracture","volume":"17","author":"Cooper","year":"2006","journal-title":"Osteoporos Int."},{"issue":"8","key":"2024020318363606500_jbmr1914-bib-0002","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1002\/jbmr.412","article-title":"Bone mineral accrual from 8 to 30 years of age: an estimation of peak bone mass","volume":"26","author":"Baxter-Jones","year":"2011","journal-title":"J Bone Miner Res."},{"issue":"12","key":"2024020318363606500_jbmr1914-bib-0003","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1007\/s001980200137","article-title":"How many children remain fracture-free during growth? a longitudinal study of children and adolescents participating in the Dunedin Multidisciplinary Health and Development Study","volume":"13","author":"Jones","year":"2002","journal-title":"Osteoporos Int."},{"issue":"1","key":"2024020318363606500_jbmr1914-bib-0004","doi-asserted-by":"crossref","first-page":"148","DOI":"10.3109\/17453671003628780","article-title":"Epidemiology of fractures in children and adolescents","volume":"81","author":"Hedstr\u00f6m","year":"2010","journal-title":"Acta Orthopaedica."},{"issue":"11","key":"2024020318363606500_jbmr1914-bib-0005","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1001\/jama.290.11.1479","article-title":"Incidence of childhood distal forearm fractures over 30 years: a population-based study","volume":"290","author":"Khosla","year":"2003","journal-title":"JAMA."},{"issue":"12","key":"2024020318363606500_jbmr1914-bib-0006","first-page":"2752","article-title":"Decreasing incidence and changing pattern of childhood fractures: a population-based study. 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