{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T22:49:55Z","timestamp":1791240595334,"version":"4.1.0"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2013,5,9]],"date-time":"2013-05-09T00:00:00Z","timestamp":1368057600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,11,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>\u2003<\/jats:title>\n                  <jats:p>We aimed to identify all patients with postsurgical hypoparathyroidism (HypoPT) and to evaluate their risks of renal complications and cardiovascular disease in relation to their disease and its treatment. We identified possible patients through the Danish National Patient Registry and a prescription database. Case status was adjudicated by review of individual patients' hospital records. For each patient with postsurgical HypoPT due to surgery for nonmalignant diseases between 1988 and 2012, three age-matched (\u00b1\u20092 years) and gender-matched controls were selected from the general background population. The prevalence of postsurgical HypoPT was 22 per 100,000 inhabitants. We identified 688 patients who had undergone neck surgery since 1988 with subsequent hypocalcaemia and inappropriate low parathyroid hormone (PTH) levels that necessitated treatment with calcium and\/or vitamin D supplementation for more than 6 months. The average age at diagnosis was 49 years (range, 17\u201387 years), and 88% were women. Sixteen percent of all patients had had neck surgery prior to the operation causing HypoPT. Compared with controls, patients with HypoPT had an increased risk of renal complications (hazard ratio [HR], 3.67; 95% confidence interval [CI], 2.41\u20135.59) and hospitalization due to seizures (HR, 3.82; 95% CI, 2.15\u20136.79), whereas there was no increased risk of cardiac arrhythmias (HR, 1.11; 95% CI, 0.79\u20131.57) or cardiovascular disease or death (HR, 0.89; 95% CI, 0.73\u20131.09). In conclusion, although risk of seizures and renal complications is increased, mortality and risk of cardiovascular diseases or arrhythmias is not increased in patients with HypoPT. Further study should try to determine how to reduce the risk of seizures and renal complications in HypoPT. \u00a9 2013 American Society for Bone and Mineral Research.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/jbmr.1979","type":"journal-article","created":{"date-parts":[[2013,5,9]],"date-time":"2013-05-09T15:21:57Z","timestamp":1368112917000},"page":"2277-2285","source":"Crossref","is-referenced-by-count":272,"title":["Cardiovascular and renal complications to postsurgical hypoparathyroidism: A Danish nationwide controlled historic follow-up study"],"prefix":"10.1093","volume":"28","author":[{"given":"Line","family":"Underbjerg","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Internal MedicineAarhus University HospitalTage Hansens Gade (THG)AarhusDenmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanja","family":"Sikjaer","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Internal MedicineAarhus University HospitalTage Hansens Gade (THG)AarhusDenmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leif","family":"Mosekilde","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Internal MedicineAarhus University HospitalTage Hansens Gade (THG)AarhusDenmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Rejnmark","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Internal MedicineAarhus University HospitalTage Hansens Gade (THG)AarhusDenmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,5,9]]},"reference":[{"key":"2024020318341289400_jbmr1979-bib-0001","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1056\/NEJMcp0803050","article-title":"Clinical practice. Hypoparathyroidism","volume":"359","author":"Shoback","year":"2008","journal-title":"N Engl J Med."},{"key":"2024020318341289400_jbmr1979-bib-0002","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1056\/NEJM200012213432508","article-title":"Hyperparathyroid and hypoparathyroid disorders","volume":"343","author":"Marx","year":"2000","journal-title":"N Engl J Med."},{"issue":"4","key":"2024020318341289400_jbmr1979-bib-0003","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/s00423-006-0097-6","article-title":"Scandinavian Quality Register for Thyroid and Parathyroid Surgery: audit of surgery for primary hyperparathyroidism","volume":"392","author":"Bergenfelz","year":"2007","journal-title":"Langenbecks Arch Surg."},{"key":"2024020318341289400_jbmr1979-bib-0004","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1097\/00000658-200211000-00001","article-title":"Unilateral versus bilateral neck exploration for primary hyperparathyroidism: a prospective randomized controlled trial","volume":"236","author":"Bergenfelz","year":"2002","journal-title":"Ann Surg."},{"issue":"3","key":"2024020318341289400_jbmr1979-bib-0005","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s00268-003-6903-1","article-title":"Complications of thyroid surgery: analysis of a multicentric study on 14,934 patients operated on in Italy over 5 years","volume":"28","author":"Rosato","year":"2004","journal-title":"World J Surg."},{"key":"2024020318341289400_jbmr1979-bib-0006","article-title":"Co-morbid medical conditions associated with prevalent hypoparathyroidism: a population-based study","author":"Clarke","year":"2011","journal-title":"J Bone Miner Res."},{"issue":"10","key":"2024020318341289400_jbmr1979-bib-0007","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1002\/jbmr.483","article-title":"Hypoparathyroidism in the adult: epidemiology, diagnosis, pathophysiology, target organ involvement, treatment, and challenges for future research","volume":"26","author":"Bilezikian","year":"2011","journal-title":"J Bone Miner Res."},{"key":"2024020318341289400_jbmr1979-bib-0008","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.beem.2012.01.004","article-title":"Hypoparathyroidism","volume":"26","author":"Al-Azem","year":"2012","journal-title":"Best Pract Res Clin Endocrinol Metab."},{"key":"2024020318341289400_jbmr1979-bib-0009","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1001\/archinte.167.16.1730","article-title":"Vitamin D supplementation and total mortality: a meta-analysis of randomized controlled trials","volume":"167","author":"Autier","year":"2007","journal-title":"Arch Intern Med."},{"key":"2024020318341289400_jbmr1979-bib-0010","doi-asserted-by":"crossref","first-page":"2670","DOI":"10.1210\/jc.2011-3328","article-title":"Vitamin D with calcium reduces mortality: patient level pooled analysis of 70,528 patients from eight major vitamin D trials","volume":"97","author":"Rejnmark","year":"2012","journal-title":"J Clin Endocrinol Metab."},{"key":"2024020318341289400_jbmr1979-bib-0011","doi-asserted-by":"crossref","first-page":"d2040","DOI":"10.1136\/bmj.d2040","article-title":"Calcium supplements with or without vitamin D and risk of cardiovascular events: reanalysis of the Women's Health Initiative limited access dataset and meta-analysis","volume":"342","author":"Bolland","year":"2011","journal-title":"BMJ."},{"key":"2024020318341289400_jbmr1979-bib-0012","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1056\/NEJMoa055218","article-title":"Women's Health Initiative Investigators. 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