{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T23:06:35Z","timestamp":1767135995067,"version":"build-2238731810"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2013,5,29]],"date-time":"2013-05-29T00:00:00Z","timestamp":1369785600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,9,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>\u2003<\/jats:title>\n                    <jats:p>To assess the effect of hypoparathyroidism on osteogenesis and bone turnover in vivo, bone marrow ablation (BMXs) were performed in tibias of 8-week-old wild-type and parathyroid hormone\u2013null (PTH\u2212\/\u2212) mice and newly formed bone tissue was analyzed from 5 days to 3 weeks after BMX. At 1 week after BMX, trabecular bone volume, osteoblast numbers, alkaline phosphatase-positive areas, type I collagen-positive areas, PTH receptor\u2013positive areas, calcium sensing receptor\u2013positive areas, and expression of bone formation\u2013related genes were all decreased significantly in the diaphyseal regions of bones of PTH\u2212\/\u2212 mice compared to wild-type mice. In contrast, by 2 weeks after BMX, all parameters related to osteoblastic bone accrual were increased significantly in PTH\u2212\/\u2212 mice. At 5 days after BMX, active tartrate-resistant acid phosphatase (TRAP)-positive osteoclasts had appeared in wild-type mice but were undetectable in PTH\u2212\/\u2212 mice, Both the ratio of mRNA levels of receptor activator of NF-\u03baB ligand (RANKL)\/osteoprotegerin (OPG) and TRAP-positive osteoclast surface were still reduced in PTH\u2212\/\u2212 mice at 1 week but were increased by 2 weeks after BMX. The expression levels of parathyroid hormone\u2013related protein (PTHrP) at both mRNA and protein levels were upregulated significantly at 1 week and more dramatically at 2 weeks after BMX in PTH\u2212\/\u2212 mice. To determine whether the increased newly formed bones in PTH\u2212\/\u2212 mice at 2 weeks after BMX resulted from the compensatory action of PTHrP, PTH\u2212\/\u2212PTHrP+\/\u2212 mice were generated and newly formed bone tissue was compared in these mice with PTH\u2212\/\u2212 and wild-type mice at 2 weeks after BMX. All parameters related to osteoblastic bone formation and osteoclastic bone resorption were reduced significantly in PTH\u2212\/\u2212PTHrP+\/\u2212 mice compared to PTH\u2212\/\u2212 mice. These results demonstrate that PTH deficiency itself impairs osteogenesis, osteoclastogenesis, and osteoclastic bone resorption, whereas subsequent upregulation of PTHrP in osteogenic cells compensates by increasing bone accrual. \u00a9 2013 American Society for Bone and Mineral Research<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jbmr.2000","type":"journal-article","created":{"date-parts":[[2013,5,29]],"date-time":"2013-05-29T07:16:07Z","timestamp":1369811767000},"page":"1898-1911","source":"Crossref","is-referenced-by-count":12,"title":["Endogenous parathyroid hormone\u2013related protein compensates for the absence of parathyroid hormone in promoting bone accrual in vivo in a model of bone marrow ablation"],"prefix":"10.1093","volume":"28","author":[{"given":"Qi","family":"Zhu","sequence":"first","affiliation":[{"name":"The State Key Laboratory of Reproductive Medicine, The Research Center for Bone and Stem Cells, Department of AnatomyHistology and Embryology, Nanjing 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Disord."},{"issue":"3","key":"2024020318352957100_jbmr2000-bib-0031","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1177\/002215540205000305","article-title":"Histochemical localization of alkaline phosphatase activity in decalcified bone and cartilage","volume":"50","author":"Miao","year":"2002","journal-title":"J Histochem Cytochem."},{"issue":"2","key":"2024020318352957100_jbmr2000-bib-0032","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1210\/en.2008-0654","article-title":"Parathyroid hormone contributes to regulating milk calcium content and modulates neonatal bone formation cooperatively with calcium","volume":"150","author":"Cao","year":"2009","journal-title":"Endocrinology."},{"issue":"5","key":"2024020318352957100_jbmr2000-bib-0033","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1002\/jbmr.300","article-title":"The calcium-sensing receptor mediates bone turnover induced by dietary calcium and parathyroid hormone in 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hematopoiesis in bone and of skeletal stem cells in the bone marrow","volume":"167","author":"Kuznetsov","year":"2004","journal-title":"J Cell Biol."},{"issue":"50","key":"2024020318352957100_jbmr2000-bib-0037","doi-asserted-by":"crossref","first-page":"50259","DOI":"10.1074\/jbc.M307444200","article-title":"Proteasomal degradation of Runx2 shortens parathyroid hormone-induced anti-apoptotic signaling in osteoblasts. 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Abdaimi","year":"1999","journal-title":"Cancer Res."},{"issue":"1\u20132","key":"2024020318352957100_jbmr2000-bib-0050","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.mce.2011.05.025","article-title":"1,25-Dihydroxyvitamin D(3) regulates PTHrP expression via transcriptional, post-transcriptional and post-translational pathways","volume":"342","author":"Bhatia","year":"2011","journal-title":"Mol Cell Endocrinol."},{"issue":"6","key":"2024020318352957100_jbmr2000-bib-0051","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.bone.2005.11.009","article-title":"The calcium-sensing receptor regulates PTHrP production and calcium transport in the lactating mammary gland","volume":"38","author":"Ardeshirpour","year":"2006","journal-title":"Bone."},{"issue":"4","key":"2024020318352957100_jbmr2000-bib-0052","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1172\/JCI200418776","article-title":"The calcium-sensing receptor regulates mammary gland parathyroid 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