{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T16:49:39Z","timestamp":1787849379207,"version":"build-2784847793"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2013,6,5]],"date-time":"2013-06-05T00:00:00Z","timestamp":1370390400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,12,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>\u2003<\/jats:title>\n                    <jats:p>Hypoparathyroidism is a rare endocrine disorder whose incidence and prevalence have not been well defined. This study aimed to 1) estimate the number of insured adult patients with hypoparathyroidism in the United States and 2) obtain physician assessment of disease severity and chronicity. Prevalence was estimated through calculation of diagnoses of hypoparathyroidism in a large proprietary health plan claims database over a 12-month period from October 2007 through September 2008 and projected to the US insured population. Incidence was also calculated from the same database by determining the proportion of total neck surgeries resulting in either transient (\u22646 months) or chronic (&amp;gt;6 months) hypoparathyroidism. A physician primary market research study was conducted to assess disease severity and determine the percentage of new nonsurgical patients with hypoparathyroidism. Incidence data were entered into an epidemiologic model to derive an estimate of prevalence. The diagnosis-based prevalence approach estimated 58,793 insured patients with chronic hypoparathyroidism in the United States. The surgical-based incidence approach yielded 117,342 relevant surgeries resulting in 8901 cases over 12 months. Overall, 7.6% of surgeries resulted in hypoparathyroidism (75% transient, 25% chronic). The prevalence of chronic hypoparathyroidism among insured patients included in the surgical database was estimated to be 58,625. The physician survey found that 75% of cases treated over the past 12 months were reported due to surgery and, among all thyroidectomies and parathyroidectomies and neck dissections performed in a year, 26% resulted in transient hypoparathyroidism and 5% progressed to a chronic state. In conclusion, the two claims-based methods yielded similar estimates of the number of insured patients with chronic hypoparathyroidism in the United States (\u223c58,700). The physician survey was consistent with those calculations and confirmed the burden imposed by hypoparathyroidism. \u00a9 2013 American Society for Bone and Mineral Research.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jbmr.2004","type":"journal-article","created":{"date-parts":[[2013,6,5]],"date-time":"2013-06-05T07:31:23Z","timestamp":1370417483000},"page":"2570-2576","source":"Crossref","is-referenced-by-count":157,"title":["Prevalence and Incidence of Hypoparathyroidism in the United States Using a Large Claims Database"],"prefix":"10.1093","volume":"28","author":[{"given":"Julia","family":"Powers","sequence":"first","affiliation":[{"name":"IMS HealthAlexandriaVAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Joy","sequence":"additional","affiliation":[{"name":"IMS HealthAlexandriaVAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aimee","family":"Ruscio","sequence":"additional","affiliation":[{"name":"IMS HealthAlexandriaVAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hjalmar","family":"Lagast","sequence":"additional","affiliation":[{"name":"NPS Pharmaceuticals, Inc.BedminsterNJUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,6,5]]},"reference":[{"key":"2024020318332206900_jbmr2004-bib-0001","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1056\/NEJMcp0803050","article-title":"Clinical practice. Hypoparathyroidism","volume":"359","author":"Shoback","year":"2008","journal-title":"N Engl J Med."},{"key":"2024020318332206900_jbmr2004-bib-0002","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1089\/thy.2008.0306","article-title":"Postoperative hypoparathyroidism: medical and surgical therapeutic options","volume":"19","author":"Walker Harris","year":"2009","journal-title":"Thyroid."},{"key":"2024020318332206900_jbmr2004-bib-0003","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1002\/jbmr.483","article-title":"Hypoparathyroidism in the adult: epidemiology, diagnosis, pathophysiology, target-organ involvement, treatment, and challenges for future research","volume":"26","author":"Bilezikian","year":"2011","journal-title":"J Bone Miner Res."},{"key":"2024020318332206900_jbmr2004-bib-0004","doi-asserted-by":"crossref","first-page":"3307","DOI":"10.1210\/jc.2008-1216","article-title":"Hypoparathyroidism: is it time for replacement therapy?","volume":"93","author":"Horwitz","year":"2008","journal-title":"J Clin Endocrinol Metab."},{"key":"2024020318332206900_jbmr2004-bib-0005","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1056\/NEJM200012213432508","article-title":"Hyperparathyroid and hypoparathyroid disorders","volume":"343","author":"Marx","year":"2000","journal-title":"N Engl J Med."},{"key":"2024020318332206900_jbmr2004-bib-0006","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.rdc.2010.09.002","article-title":"Parathyroid disease","volume":"36","author":"Wen","year":"2010","journal-title":"Rheum Dis Clin North Am."},{"key":"2024020318332206900_jbmr2004-bib-0007","first-page":"S182","article-title":"Co-morbid medical conditions associated with prevalent hypoparathyroidism: a population-based study [abstract SA0170]","volume":"26","author":"Clarke","year":"2011","journal-title":"J Bone Miner Res."},{"key":"2024020318332206900_jbmr2004-bib-0008","doi-asserted-by":"crossref","first-page":"18","DOI":"10.4158\/EP10302.RA","article-title":"Medical management of postsurgical hypoparathyroidism","volume":"17","author":"Khan","year":"2011","journal-title":"Endocr Pract."},{"key":"2024020318332206900_jbmr2004-bib-0009","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jss.2010.03.059","article-title":"Parathyroid hormone deficiency after total thyroidectomy: incidence and time","volume":"163","author":"Youngwirth","year":"2010","journal-title":"J Surg Res."},{"key":"2024020318332206900_jbmr2004-bib-0010","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1007\/s00423-008-0366-7","article-title":"Complications to thyroid surgery: results as reported in a database from a multicenter audit comprising 3,660 patients","volume":"393","author":"Bergenfelz","year":"2008","journal-title":"Langenbecks Arch Surg."},{"key":"2024020318332206900_jbmr2004-bib-0011","first-page":"827","article-title":"Hormone replacement after thyroid and parathyroid surgery","volume":"107","author":"Schaffler","year":"2010","journal-title":"Dtsch Arztebl Int."},{"key":"2024020318332206900_jbmr2004-bib-0012","doi-asserted-by":"crossref","first-page":"89","DOI":"10.2174\/157488611795684631","article-title":"PTH treatment in hypoparathyroidism","volume":"6","author":"Sikjaer","year":"2011","journal-title":"Curr Drug Saf."},{"key":"2024020318332206900_jbmr2004-bib-0013","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1530\/eje.0.1460215","article-title":"Well-being, mood and calcium homeostasis in patients with hypoparathyroidism receiving standard treatment with calcium and vitamin D","volume":"146","author":"Arlt","year":"2002","journal-title":"Eur J Endocrinol."},{"key":"2024020318332206900_jbmr2004-bib-0014","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1016\/j.cgh.2007.07.012","article-title":"The prevalence and geographic distribution of Crohn's disease and ulcerative colitis in the United States","volume":"5","author":"Kappelman","year":"2007","journal-title":"Clin Gastroenterol Hepatol."},{"key":"2024020318332206900_jbmr2004-bib-0015","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.4088\/JCP.v67n0803","article-title":"Overlap of anxiety and depression in a managed care population: prevalence and association with resource utilization","volume":"67","author":"McLaughlin","year":"2006","journal-title":"J Clin Psychiatry."},{"key":"2024020318332206900_jbmr2004-bib-0016","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1097\/01.ju.0000125198.32936.38","article-title":"The prevalence of hypertension, hyperlipidemia, diabetes mellitus and depression in men with erectile dysfunction","volume":"171","author":"Seftel","year":"2004","journal-title":"J Urol."},{"key":"2024020318332206900_jbmr2004-bib-0017","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1016\/S0149-2918(01)80136-3","article-title":"Prevalence of treated dry eye disease in a managed care population","volume":"23","author":"Yazdani","year":"2001","journal-title":"Clin Ther."},{"key":"2024020318332206900_jbmr2004-bib-0018","doi-asserted-by":"crossref","first-page":"4507","DOI":"10.1210\/jc.2012-1808","article-title":"Long-term follow-up of patients with hypoparathyroidism","volume":"97","author":"Mitchell","year":"2012","journal-title":"J Clin Endocrinol Metab."},{"key":"2024020318332206900_jbmr2004-bib-0019","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/s00423-006-0113-x","article-title":"A clinical chameleon: postoperative hypoparathyroidism","volume":"392","author":"Bohrer","year":"2007","journal-title":"Langenbecks Arch Surg."},{"key":"2024020318332206900_jbmr2004-bib-0020","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1089\/thy.2012.0011","article-title":"Complications of central neck dissection in patients with papillary thyroid carcinoma: results of a study on 1087 patients and review of the literature","volume":"22","author":"Giordano","year":"2012","journal-title":"Thyroid."},{"key":"2024020318332206900_jbmr2004-bib-0021","doi-asserted-by":"crossref","first-page":"3186","DOI":"10.1007\/s00464-010-1113-z","article-title":"Differences in postoperative outcomes, function, and cosmesis: open versus robotic thyroidectomy","volume":"24","author":"Lee","year":"2010","journal-title":"Surg Endosc."},{"key":"2024020318332206900_jbmr2004-bib-0022","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1002\/jso.21367","article-title":"Comparative study of endoscopic thyroidectomy versus conventional open thyroidectomy in papillary thyroid microcarcinoma (PTMC) patients","volume":"100","author":"Jeong","year":"2009","journal-title":"J Surg Oncol."}],"container-title":["Journal of Bone and Mineral Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbmr.2004","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/28\/12\/2570\/56562771\/jbmr2004.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/28\/12\/2570\/56562771\/jbmr2004.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T10:49:45Z","timestamp":1710326985000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbmr\/article\/28\/12\/2570-2576\/7598580"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,5]]},"references-count":22,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2013,6,5]]},"published-print":{"date-parts":[[2013,12,1]]}},"URL":"https:\/\/doi.org\/10.1002\/jbmr.2004","relation":{},"ISSN":["0884-0431","1523-4681"],"issn-type":[{"value":"0884-0431","type":"print"},{"value":"1523-4681","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2013,12,1]]},"published":{"date-parts":[[2013,6,5]]}}}