{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T06:39:55Z","timestamp":1789540795795,"version":"build-2803163510"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2013,6,6]],"date-time":"2013-06-06T00:00:00Z","timestamp":1370476800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,1,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>\u2003<\/jats:title>\n                  <jats:p>Young women with anorexia nervosa (AN) have reduced secretion of dehydroepiandrosterone (DHEA) and estrogen contributing to skeletal deficits. In this randomized, placebo-controlled trial, we investigated the effects of oral DHEA\u2009+\u2009combined oral contraceptive (COC) versus placebo on changes in bone geometry in young women with AN. Eighty women with AN, aged 13 to 27 years, received a random, double-blinded assignment to micronized DHEA (50\u2009mg\/day)\u2009+\u2009COC (20\u2009\u00b5g ethinyl estradiol\/0.1\u2009mg levonorgestrel) or placebo for 18 months. Measurements of areal bone mineral density (aBMD) at the total hip were obtained by dual-energy X-ray absorptiometry at 0, 6, 12, and 18 months. We used the Hip Structural Analysis (HSA) program to determine BMD, cross-sectional area (CSA), and section modulus at the femoral neck and shaft. Each measurement was expressed as a percentage of the age-, height-, and lean mass-specific mean from an independent sample of healthy adolescent females. Over the 18 months, DHEA\u2009+\u2009COC led to stabilization in femoral shaft BMD (0.0\u2009\u00b1\u20090.5% of normal mean for age, height, and lean mass\/year) compared with decreases in the placebo group (\u22121.1\u2009\u00b1\u20090.5% per year, p\u2009=\u20090.03). Similarly, CSA, section modulus, and cortical thickness improved with treatment. In young women with AN, adrenal and gonadal hormone replacement improved bone health and increased cross-sectional geometry. Our results indicate that this combination treatment has a beneficial impact on surrogate measures of bone strength, and not only bone density, in young women with AN. \u00a9 2014 American Society for Bone and Mineral Research.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/jbmr.2005","type":"journal-article","created":{"date-parts":[[2013,6,6]],"date-time":"2013-06-06T13:59:31Z","timestamp":1370527171000},"page":"151-157","source":"Crossref","is-referenced-by-count":58,"title":["Does Hormone Replacement Normalize Bone Geometry in Adolescents With Anorexia Nervosa?"],"prefix":"10.1093","volume":"29","author":[{"given":"Amy D","family":"DiVasta","sequence":"first","affiliation":[{"name":"Division of Pediatric and Adolescent GynecologyBoston Children's HospitalBostonMAUSA"},{"name":"Division of Adolescent and Young Adult MedicineBoston Children's HospitalBostonMAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry A","family":"Feldman","sequence":"additional","affiliation":[{"name":"Division of EndocrinologyBoston Children's HospitalBostonMAUSA"},{"name":"Clinical Research ProgramBoston Children's HospitalBostonMAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J","family":"Beck","sequence":"additional","affiliation":[{"name":"Beck Radiological InnovationsInc.BaltimoreMDUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meryl S","family":"LeBoff","sequence":"additional","affiliation":[{"name":"Division of EndocrinologyBrigham and Women's HospitalBostonMAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine M","family":"Gordon","sequence":"additional","affiliation":[{"name":"Divison of EndocrinologyHasbro Children's HospitalProvidenceRIUSA"},{"name":"Divison of Adolescent MedicineHasbro Children's HospitalProvidenceRIUSA"},{"name":"Division of EndocrinologyBoston Children's HospitalBostonMAUSA"},{"name":"Division of Adolescent and Young Adult MedicineBoston Children's HospitalBostonMAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,6,6]]},"reference":[{"issue":"3","key":"2024020318582321300_jbmr2005-bib-0001","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1210\/jcem-69-3-533","article-title":"Sex steroids and bone density in premenopausal and perimenopausal women","volume":"69","author":"Steinberg","year":"1989","journal-title":"J Clin Endocrinol Metab."},{"issue":"2","key":"2024020318582321300_jbmr2005-bib-0002","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/S0889-8529(18)30274-3","article-title":"Adrenal androgen secretion and biologic effects","volume":"20","author":"Meikle","year":"1991","journal-title":"Endocrinol Metab Clin N Am."},{"issue":"3","key":"2024020318582321300_jbmr2005-bib-0003","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1210\/jcem-59-3-551","article-title":"Age changes and sex 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