{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T17:16:12Z","timestamp":1792602972669,"version":"4.5.0"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2013,6,21]],"date-time":"2013-06-21T00:00:00Z","timestamp":1371772800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,1,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>\u2003<\/jats:title>\n                  <jats:p>Antiosteoporosis medication (AOM) does not abolish fracture risk, and some individuals experience multiple fractures while on treatment. Therefore, criteria for treatment failure have recently been defined. Using data from the Global Longitudinal Study of Osteoporosis in Women (GLOW), we analyzed risk factors for treatment failure, defined as sustaining two or more fractures while on AOM. GLOW is a prospective, observational cohort study of women aged \u226555 years sampled from primary care practices in 10 countries. Self-administered questionnaires collected data on patient characteristics, fracture risk factors, previous fractures, AOM use, and health status. Data were analyzed from women who used the same class of AOM continuously over 3 survey years and had data available on fracture occurrence. Multivariable logistic regression was used to identify independent predictors of treatment failure. Data from 26,918 women were available, of whom 5550 were on AOM. During follow-up, 73 of 5550 women in the AOM group (1.3%) and 123 of 21,368 in the non-AOM group (0.6%) reported occurrence of two or more fractures. The following variables were associated with treatment failure: lower Short Form 36 Health Survey (SF-36) score (physical function and vitality) at baseline, higher Fracture Risk Assessment Tool (FRAX) score, falls in the past 12 months, selected comorbid conditions, prior fracture, current use of glucocorticoids, need of arms to assist to standing, and unexplained weight loss \u226510 lb (\u22654.5\u2009kg). Three variables remained predictive of treatment failure after multivariable analysis: worse SF-36 vitality score (odds ratio [OR] per 10-point increase, 0.85; 95% confidence interval [CI], 0.76\u20130.95; p\u2009=\u20090.004); two or more falls in the past year (OR, 2.40; 95% CI, 1.34\u20134.29; p\u2009=\u20090.011), and prior fracture (OR, 2.93; 95% CI, 1.81\u20134.75; p\u2009&amp;lt;\u20090.0001). The C statistic for the model was 0.712. Specific strategies for fracture prevention should therefore be developed for this subgroup of patients. \u00a9 2014 American Society for Bone and Mineral Research.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/jbmr.2023","type":"journal-article","created":{"date-parts":[[2013,6,21]],"date-time":"2013-06-21T14:01:44Z","timestamp":1371823304000},"page":"260-267","source":"Crossref","is-referenced-by-count":52,"title":["Risk Factors for Treatment Failure With Antiosteoporosis Medication: The Global Longitudinal Study of Osteoporosis in Women (GLOW)"],"prefix":"10.1093","volume":"29","author":[{"given":"Adolfo","family":"D\u00edez-P\u00e9rez","sequence":"first","affiliation":[{"name":"Red Tematica Investigacion en Envejecimiento y Fragilidad (RETICEF)Instituto Carlos IIIBarcelonaSpain"},{"name":"Hospital del Mar-IMIM-Autonomous University of BarcelonaBarcelonaSpain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan D","family":"Adachi","sequence":"additional","affiliation":[{"name":"St. Joseph's HospitalMcMaster UniversityHamiltonOntarioCanada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvano","family":"Adami","sequence":"additional","affiliation":[{"name":"Department of RheumatologyUniversity of VeronaOspedaleVerona, ValeggioItaly"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Frederick A","family":"Anderson","sequence":"additional","affiliation":[{"name":"Center for Outcomes ResearchUniversity of Massachusetts Medical SchoolWorcesterMAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Boonen","sequence":"additional","affiliation":[{"name":"Leuven University Center for Metabolic Bone DiseasesDivision of Geriatric MedicineKatholieke Universiteit LeuvenLeuvenBelgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Chapurlat","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM; National Institute of Health and Medical Research) U831Universit\u00e9 de Lyon, Division of Rheumatology, H\u00f4pital E. HerriotLyonFrance"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliet E","family":"Compston","sequence":"additional","affiliation":[{"name":"School of Clinical MedicineAddenbrooke's HospitalUniversity of CambridgeCambridgeUK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyrus","family":"Cooper","sequence":"additional","affiliation":[{"name":"Medical Research Council (MRC) Lifecourse Epidemiology UnitUniversity of Southampton, Southampton General HospitalSouthamptonUK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen H","family":"Gehlbach","sequence":"additional","affiliation":[{"name":"Center for Outcomes ResearchUniversity of Massachusetts Medical SchoolWorcesterMAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan L","family":"Greenspan","sequence":"additional","affiliation":[{"name":"University of PittsburghPittsburghPennsylvaniaUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederick H","family":"Hooven","sequence":"additional","affiliation":[{"name":"Center for Outcomes ResearchUniversity of Massachusetts Medical SchoolWorcesterMAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea Z","family":"LaCroix","sequence":"additional","affiliation":[{"name":"Fred Hutchinson Cancer Research CenterSeattleWAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeri W","family":"Nieves","sequence":"additional","affiliation":[{"name":"Helen Hayes Hospital and Columbia UniversityWest HaverstrawNew YorkUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J Coen","family":"Netelenbos","sequence":"additional","affiliation":[{"name":"Department of EndocrinologyVrije Universiteit (VU) University Medical CenterAmsterdamThe Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Pfeilschifter","sequence":"additional","affiliation":[{"name":"Alfried Krupp KrankenhausDepartment of Internal Medicine IIIEssenGermany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Rossini","sequence":"additional","affiliation":[{"name":"Department of RheumatologyUniversity of VeronaVeronaItaly"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Roux","sequence":"additional","affiliation":[{"name":"Paris Descartes UniversityCochin HospitalParisFrance"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth G","family":"Saag","sequence":"additional","affiliation":[{"name":"University of Alabama-BirminghamBirminghamALUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart","family":"Silverman","sequence":"additional","affiliation":[{"name":"Department of RheumatologyCedars-Sinai\/University of CaliforniaLos Angeles (UCLA)Los Angeles, CAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ethel S","family":"Siris","sequence":"additional","affiliation":[{"name":"Department of MedicineColumbia University Medical CenterNew YorkNYUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison","family":"Wyman","sequence":"additional","affiliation":[{"name":"Center for Outcomes ResearchUniversity of Massachusetts Medical SchoolWorcesterMAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie K","family":"Rushton-Smith","sequence":"additional","affiliation":[{"name":"Center for Outcomes ResearchUniversity of Massachusetts Medical SchoolWorcesterMAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelson B","family":"Watts","sequence":"additional","affiliation":[{"name":"Bone Health and Osteoporosis CenterUniversity of CincinnatiCincinnatiOHUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Global Longitudinal Study of Osteoporosis in Women (GLOW) Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,6,21]]},"reference":[{"issue":"3","key":"2024020318590863300_jbmr2023-bib-0001","doi-asserted-by":"crossref","first-page":"197","DOI":"10.7326\/0003-4819-148-3-200802050-00198","article-title":"Systematic review: comparative effectiveness of treatments to prevent fractures in men and women with low bone density or osteoporosis","volume":"148","author":"MacLean","year":"2008","journal-title":"Ann Intern Med."},{"issue":"7","key":"2024020318590863300_jbmr2023-bib-0002","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1001\/jama.282.7.637","article-title":"Multiple Outcomes of Raloxifene Evaluation (MORE) Investigators. Reduction of vertebral fracture risk in postmenopausal women with osteoporosis treated with raloxifene: results from a 3-year randomized clinical trial","volume":"282","author":"Ettinger","year":"1999","journal-title":"JAMA."},{"issue":"3","key":"2024020318590863300_jbmr2023-bib-0003","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1046\/j.1532-5415.2002.50102.x","article-title":"FIT Research Group. Alendronate reduces the risk of multiple symptomatic fractures: results from the fracture intervention trial","volume":"50","author":"Levis","year":"2002","journal-title":"J Am Geriatr Soc."},{"issue":"2","key":"2024020318590863300_jbmr2023-bib-0004","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1210\/jc.2002-020400","article-title":"Risedronate prevents new vertebral fractures in postmenopausal women at high risk","volume":"88","author":"Watts","year":"2003","journal-title":"J Clin Endocrinol Metab."},{"issue":"10","key":"2024020318590863300_jbmr2023-bib-0005","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.1002\/jbmr.446","article-title":"Effects of antiresorptive treatment on nonvertebral fracture outcomes","volume":"26","author":"Mackey","year":"2011","journal-title":"J Bone Miner Res."},{"issue":"12","key":"2024020318590863300_jbmr2023-bib-0006","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1359\/jbmr.080710","article-title":"Efficacy of bazedoxifene in reducing new vertebral fracture risk in postmenopausal women with osteoporosis: results from a 3-year, randomized, placebo-, and active-controlled clinical trial","volume":"23","author":"Silverman","year":"2008","journal-title":"J Bone Miner Res."},{"issue":"18","key":"2024020318590863300_jbmr2023-bib-0007","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1056\/NEJMoa067312","article-title":"HORIZON Pivotal Fracture Trial. Once-yearly zoledronic acid for treatment of postmenopausal osteoporosis","volume":"356","author":"Black","year":"2007","journal-title":"N Engl J Med."},{"issue":"8","key":"2024020318590863300_jbmr2023-bib-0008","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1056\/NEJMoa0809493","article-title":"FREEDOM Trial. Denosumab for prevention of fractures in postmenopausal women with osteoporosis","volume":"361","author":"Cummings","year":"2009","journal-title":"N Engl J Med."},{"issue":"11","key":"2024020318590863300_jbmr2023-bib-0009","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1007\/s00198-008-0659-2","article-title":"Inadequate responders to osteoporosis treatment: proposal for an operational definition","volume":"19","author":"Diez-Perez","year":"2008","journal-title":"Osteoporos Int."},{"issue":"12","key":"2024020318590863300_jbmr2023-bib-0010","doi-asserted-by":"crossref","first-page":"2769","DOI":"10.1007\/s00198-012-2093-8","article-title":"Treatment failure in osteoporosis","volume":"23","author":"Diez-Perez","year":"2012","journal-title":"Osteoporos Int."},{"issue":"7","key":"2024020318590863300_jbmr2023-bib-0011","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1007\/s00198-009-0958-2","article-title":"The Global Longitudinal Study of Osteoporosis in Women (GLOW): rationale and study design","volume":"20","author":"Hooven","year":"2009","journal-title":"Osteoporos Int."},{"issue":"4","key":"2024020318590863300_jbmr2023-bib-0012","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/s00198-007-0543-5","article-title":"FRAX and the assessment of fracture probability in men and women from the UK","volume":"19","author":"Kanis","year":"2008","journal-title":"Osteoporos Int."},{"issue":"6846","key":"2024020318590863300_jbmr2023-bib-0013","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1136\/bmj.305.6846.160","article-title":"Validating the SF-36 health survey questionnaire: new outcome measure for primary care","volume":"305","author":"Brazier","year":"1992","journal-title":"BMJ."},{"key":"2024020318590863300_jbmr2023-bib-0014","author":"Garvan Institute: fracture risk calculator [Internet].Sydney, Australia: Garvan Institute","year":"2013"},{"key":"2024020318590863300_jbmr2023-bib-0015","first-page":"S13","article-title":"Summary of AHRQ's comparative effectiveness review of treatment to prevent fractures in men and women with low bone density or osteoporosis: update of the 2007 report","author":"Levis","year":"2012","journal-title":"J Manag Care Pharm."},{"issue":"4","key":"2024020318590863300_jbmr2023-bib-0016","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1002\/jbmr.1496","article-title":"Risk factors for prediction of inadequate response to antiresorptives","volume":"27","author":"Diez-Perez","year":"2012","journal-title":"J Bone Miner Res."},{"issue":"1","key":"2024020318590863300_jbmr2023-bib-0017","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s00198-012-2184-6","article-title":"Characteristics of patients who suffer major osteoporotic fractures despite adhering to alendronate treatment: a National Prescription registry study","volume":"24","author":"Abrahamsen","year":"2013","journal-title":"Osteoporos Int."},{"issue":"6","key":"2024020318590863300_jbmr2023-bib-0018","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s001980070097","article-title":"Study subjects and ordinary patients","volume":"11","author":"Dowd","year":"2000","journal-title":"Osteoporos Int."},{"issue":"10","key":"2024020318590863300_jbmr2023-bib-0019","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1359\/jbmr.060715","article-title":"ICARO Study Group. Fracture incidence and characterization in patients on osteoporosis treatment: the ICARO study","volume":"21","author":"Adami","year":"2006","journal-title":"J Bone Miner Res."},{"issue":"9","key":"2024020318590863300_jbmr2023-bib-0020","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1002\/jbmr.1652","article-title":"Differing risk profiles for individual fracture sites: evidence from the Global Longitudinal Study of Osteoporosis in Women (GLOW)","volume":"27","author":"Fitzgerald","year":"2012","journal-title":"J Bone Miner Res."},{"issue":"1","key":"2024020318590863300_jbmr2023-bib-0021","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1359\/jbmr.1997.12.1.152","article-title":"Vertebral deformities and functional impairment in men and women","volume":"12","author":"Burger","year":"1997","journal-title":"J Bone Mineral Res."}],"container-title":["Journal of Bone and Mineral Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbmr.2023","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/29\/1\/260\/56567277\/jbmr2023.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/29\/1\/260\/56567277\/jbmr2023.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T14:49:54Z","timestamp":1710341394000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbmr\/article\/29\/1\/260-267\/7599137"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,21]]},"references-count":21,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2013,6,21]]},"published-print":{"date-parts":[[2014,1,1]]}},"URL":"https:\/\/doi.org\/10.1002\/jbmr.2023","relation":{},"ISSN":["0884-0431","1523-4681"],"issn-type":[{"value":"0884-0431","type":"print"},{"value":"1523-4681","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2014,1,1]]},"published":{"date-parts":[[2013,6,21]]}}}