{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T10:54:33Z","timestamp":1791888873900,"version":"4.3.4"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2013,7,2]],"date-time":"2013-07-02T00:00:00Z","timestamp":1372723200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,2,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>\u2003<\/jats:title>\n                  <jats:p>MicroRNAs (miRNAs) play important roles in osteoclastogenesis and bone resorption. However, no study has investigated the role of miRNA in postmenopausal osteoporosis. Here, we report that miR-503 was markedly reduced in circulating progenitors of osteoclasts\u2013CD14+ peripheral blood mononuclear cells (PBMCs) from postmenopausal osteoporosis patients compared with those from postmenopausal healthy women. Overexpression of miR-503 in CD14+ PBMCs inhibited receptor activator of nuclear factor-\u03baB ligand (RANKL)-induced osteoclastogenesis. Conversely, silencing of miR-503 in CD14+ PBMCs promoted osteoclastogenesis. RANK, which is activated by the binding of RANKL and inducing osteoclast differentiation, was confirmed to be a target of miR-503. In vivo, silencing of miR-503 using a specific antagomir in ovariectomy (OVX) mice increased RANK protein expression, promoted bone resorption, and decreased bone mass, whereas overexpression of miR-503 with agomir inhibited bone resorption and prevented bone loss in OVX mice. Thus, our study revealed that miR-503 plays an important role in the pathogenesis of postmenopausal osteoporosis and contributes to a new therapeutic way for osteoporosis. \u00a9 2014 American Society for Bone and Mineral Research.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/jbmr.2032","type":"journal-article","created":{"date-parts":[[2013,7,2]],"date-time":"2013-07-02T12:23:00Z","timestamp":1372767780000},"page":"338-347","source":"Crossref","is-referenced-by-count":191,"title":["MiR-503 Regulates Osteoclastogenesis via Targeting RANK"],"prefix":"10.1093","volume":"29","author":[{"given":"Chao","family":"Chen","sequence":"first","affiliation":[{"name":"Institute of Endocrinology & MetabolismThe Second Xiangya Hospital of Central South UniversityChangshaPR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Cheng","sequence":"additional","affiliation":[{"name":"Institute of Endocrinology & MetabolismThe Second Xiangya Hospital of Central South UniversityChangshaPR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Xie","sequence":"additional","affiliation":[{"name":"Institute of Endocrinology & MetabolismThe Second Xiangya Hospital of Central South UniversityChangshaPR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hou-De","family":"Zhou","sequence":"additional","affiliation":[{"name":"Institute of Endocrinology & MetabolismThe Second Xiangya Hospital of Central South UniversityChangshaPR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian-Ping","family":"Wu","sequence":"additional","affiliation":[{"name":"Institute of Endocrinology & MetabolismThe Second Xiangya Hospital of Central South UniversityChangshaPR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Er-Yuan","family":"Liao","sequence":"additional","affiliation":[{"name":"Institute of Endocrinology & MetabolismThe Second Xiangya Hospital of Central South 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