{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T16:11:48Z","timestamp":1785773508801,"version":"3.56.0"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2013,9,25]],"date-time":"2013-09-25T00:00:00Z","timestamp":1380067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,4,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>\u2003<\/jats:title>\n                  <jats:p>Patients with primary hyperparathyroidism (PHPT) have higher bone turnover, lower bone mineral density (BMD), and an increased risk of fractures. They also have a high incidence of low vitamin D levels (25-OH-vitamin D &amp;lt;50 nmol\/L) that could worsen the negative effect on the bone. In this double-blinded clinical trial, 150 patients with PHPT were randomized, after successful parathyroidectomy (PTX), to 1-year daily treatment with either cholecalciferol 1600 IU and calcium carbonate 1000\u2009mg (D\u2009+font-family:monospace or calcium carbonate alone (D\u2013). BMD was measured in the lumbar spine, femoral neck, total hip, distal and 33% radius using dual-energy X-ray absorptiometry (DXA) before surgery and after 1 year of study medication. Median age was 60 (range 30\u201380) years and there were 119 (79%) women and 31 (21%) men; 76% had 25-OH-D &amp;lt;50 nmol\/L before PTX and 50% had persistent elevated parathyroid hormone (PTH) 6 weeks after PTX. A similar increase in BMD in the lumbar spine, femoral neck, and total hip was observed in both groups (D\u2009+\u2009: 3.6%, 3.2%, and 2.7%, p\u2009&amp;lt;\u20090.001, respectively; and D\u2013: 3.0%, 2.3%, and 2.1%, respectively, p\u2009&amp;lt;\u20090.001). Patients with vitamin D supplementation also increased their BMD in distal radius (median 2.0%; interquartile range, \u22121.7% to 5.4%; p\u2009=\u20090.013). The changes in BMD, especially in the hips, were correlated to the baseline concentrations of PTH, ionized calcium, and bone markers (p\u2009&amp;lt;\u20090.001). A benefit from vitamin D substitution was observed among patients with a persistent postoperative PTH elevation, who also improved their BMD at 33% radius and radius ultradistal (p\u2009&amp;lt;\u20090.05). In conclusion, except for a minor improvement of radius BMD, our data show no beneficial effect on BMD or bone turnover markers of vitamin D supplementation after PTX. Preoperative PTH seems to have the strongest association with improvement in BMD. \u00a9 2014 American Society for Bone and Mineral Research.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/jbmr.2102","type":"journal-article","created":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T01:01:35Z","timestamp":1381539695000},"page":"960-967","source":"Crossref","is-referenced-by-count":21,"title":["Vitamin D Supplementation After Parathyroidectomy: Effect on Bone Mineral Density\u2014A Randomized Double-Blind Study"],"prefix":"10.1093","volume":"29","author":[{"given":"Sophie","family":"Norenstedt","sequence":"first","affiliation":[{"name":"Department of Breast and Endocrine SurgeryKarolinska University HospitalStockholmSweden"},{"name":"Department of Molecular Medicine and SurgeryKarolinska InstitutetStockholmSweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ylva","family":"Pernow","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Metabolism, and DiabetesKarolinska University HospitalStockholmSweden"},{"name":"Department of Molecular Medicine and SurgeryKarolinska InstitutetStockholmSweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Zedenius","sequence":"additional","affiliation":[{"name":"Department of Breast and Endocrine SurgeryKarolinska University HospitalStockholmSweden"},{"name":"Department of Molecular Medicine and SurgeryKarolinska InstitutetStockholmSweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rgen","family":"Nordenstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Breast and Endocrine SurgeryKarolinska University HospitalStockholmSweden"},{"name":"Department of Molecular Medicine and SurgeryKarolinska InstitutetStockholmSweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"S\u00e4\u00e4f","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Metabolism, and DiabetesKarolinska University HospitalStockholmSweden"},{"name":"Department of Molecular Medicine and SurgeryKarolinska InstitutetStockholmSweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fredrik","family":"Granath","sequence":"additional","affiliation":[{"name":"Department of MedicineKarolinska InstitutetStockholmSweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inga-Lena","family":"Nilsson","sequence":"additional","affiliation":[{"name":"Department of Breast and Endocrine SurgeryKarolinska University HospitalStockholmSweden"},{"name":"Department of Molecular Medicine and SurgeryKarolinska 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