{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:57:05Z","timestamp":1781053025420,"version":"3.54.1"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2013,10,28]],"date-time":"2013-10-28T00:00:00Z","timestamp":1382918400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,5,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>\u2003<\/jats:title>\n                  <jats:p>Idiopathic osteoporosis (IOP) in children is characterized by fragility fractures and\/or low bone mineral density in otherwise healthy individuals. The aim of the present work was to measure bone mineralization density distribution (BMDD) based on quantitative backscattered electron imaging (qBEI) in children with suspected IOP. Entire cross-sectional areas of transiliac bone biopsy samples from children (n\u2009=\u200924, 17 boys; aged 6.7\u201316.6 years) with a history of fractures (n\u2009=\u200914 with at least one vertebral fracture) were analyzed for cancellous (Cn) and cortical (Ct) BMDD. Outcomes were compared with normal reference BMDD data and correlated with the patients' clinical characteristics and bone histomorphometry findings. The subjects had similar average degree but significantly higher heterogeneity of mineralization in both Cn and Ct bone (Cn.CaWidth +23%, Ct.CaWidth +15%, p\u2009&amp;lt;\u20090.001 and p\u2009=\u20090.002, respectively), together with higher percentages of low mineralized cancellous (Cn.CaLow +35%, p\u2009&amp;lt;\u20090.001) and highly mineralized cortical bone areas (Ct.CaHigh +82%, p\u2009=\u20090.032). Ct.CaWidth and Ct.CaLow were positively correlated with mineralizing surface per bone surface (MS\/BS; a primary histomorphometric determinant of bone formation) and with serum bone turnover markers (all p\u2009&amp;lt;\u20090.05). The correlations of the mineralization heterogeneity with histomorphometric and serum bone turnover indices suggest that an enhanced variation in bone turnover\/formation contributes to the increased heterogeneity of mineralization. However, it remains unclear whether the latter is cause for, or the response to the increased bone fragility in these children with suspected IOP. \u00a9 2014 American Society for Bone and Mineral Research.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/jbmr.2124","type":"journal-article","created":{"date-parts":[[2013,10,28]],"date-time":"2013-10-28T13:21:22Z","timestamp":1382966482000},"page":"1110-1117","source":"Crossref","is-referenced-by-count":18,"title":["Increased Heterogeneity of Bone Matrix Mineralization in Pediatric Patients Prone to Fractures: A Biopsy Study"],"prefix":"10.1093","volume":"29","author":[{"given":"Inari S","family":"Tamminen","sequence":"first","affiliation":[{"name":"Department of Orthopaedics and TraumatologyKuopio University HospitalKuopioFinland"},{"name":"Department of Applied PhysicsUniversity of Eastern FinlandKuopioFinland"},{"name":"Bone and Cartilage Research Unit (BCRU)University of Eastern FinlandKuopioFinland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara M","family":"Misof","sequence":"additional","affiliation":[{"name":"Ludwig Boltzmann Institute of Osteology at the Hanusch Hospital of Wiener Gebietskrankenkasse (WGKK) and Austrian Social Insurance for Occupational Risk (AUVA) Trauma Centre Meidling1st Medical DepartmentHanusch HospitalViennaAustria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Roschger","sequence":"additional","affiliation":[{"name":"Ludwig Boltzmann Institute of Osteology at the Hanusch Hospital of Wiener Gebietskrankenkasse (WGKK) and Austrian Social Insurance for Occupational Risk (AUVA) Trauma Centre Meidling1st Medical DepartmentHanusch HospitalViennaAustria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mervi K","family":"M\u00e4yr\u00e4np\u00e4\u00e4","sequence":"additional","affiliation":[{"name":"Children's HospitalHelsinki University Central Hospital and University of HelsinkiHelsinkiFinland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikael J","family":"Turunen","sequence":"additional","affiliation":[{"name":"Department of Applied PhysicsUniversity of Eastern FinlandKuopioFinland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"Isaksson","sequence":"additional","affiliation":[{"name":"Division of Solid MechanicsDepartment of OrthopedicsLund UniversityLundSweden"},{"name":"Department of Applied PhysicsUniversity of Eastern FinlandKuopioFinland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heikki","family":"Kr\u00f6ger","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and TraumatologyKuopio University HospitalKuopioFinland"},{"name":"Bone and Cartilage Research Unit (BCRU)University of Eastern 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