{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T00:55:02Z","timestamp":1789779302443,"version":"4.0.1"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2014,6,1]],"date-time":"2014-06-01T00:00:00Z","timestamp":1401580800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,6,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>\u2003<\/jats:title>\n                  <jats:p>Children who are burned &amp;gt;40% total body surface area lose significant quantities of both bone and muscle mass because of acute bone resorption, inflammation, and endogenous glucocorticoid production, which result in negative nitrogen balance. Because administration of the bisphosphonate pamidronate within 10 days of the burn injury completely prevents the bone loss, we asked whether muscle protein balance was altered by the preservation of bone. We reviewed the results from 17 burned pediatric subjects previously enrolled in a double-blind randomized controlled study of pamidronate in the prevention of post-burn bone loss and who were concurrently evaluated for muscle protein synthesis and breakdown by stable isotope infusion studies during the acute hospitalization. We found a significantly lower fractional protein synthesis rate (FSR) in the pamidronate group and a correspondingly lower rate of appearance of the amino acid tracer in venous blood, suggesting lower muscle protein turnover. Moreover, net protein balance (synthesis minus breakdown) was positive in the subjects receiving pamidronate and negative in those receiving placebo. Muscle fiber diameter was significantly greater in the pamidronate subjects and leg strength at 9 months post-burn was not different between subjects who received pamidronate and normal physically fit age-matched children studied in our lab. Leg strength in burned subjects who served as controls tended to be weaker, although not significantly so. If substantiated by a larger study, these results suggest that bone may have a paracrine mechanism to preserve muscle and this finding may have implications for the treatment of sarcopenia in the elderly. \u00a9 2014 American Society for Bone and Mineral Research.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/jbmr.2162","type":"journal-article","created":{"date-parts":[[2013,12,18]],"date-time":"2013-12-18T11:30:43Z","timestamp":1387366243000},"page":"1369-1372","source":"Crossref","is-referenced-by-count":54,"title":["Pamidronate Attenuates Muscle Loss After Pediatric Burn Injury"],"prefix":"10.1093","volume":"29","author":[{"given":"Elisabet","family":"B\u00f8rsheim","sequence":"first","affiliation":[{"name":"Shriners Hospital for ChildrenGalvestonTXUSA"},{"name":"Department of SurgeryUniversity of Texas Medical BranchGalvestonTXUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David N","family":"Herndon","sequence":"additional","affiliation":[{"name":"Shriners Hospital for ChildrenGalvestonTXUSA"},{"name":"Department of SurgeryUniversity of Texas Medical BranchGalvestonTXUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hal K","family":"Hawkins","sequence":"additional","affiliation":[{"name":"Department of PathologyUniversity of Texas Medical BranchGalvestonTXUSA"},{"name":"Shriners Hospital for ChildrenGalvestonTXUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar E","family":"Suman","sequence":"additional","affiliation":[{"name":"Shriners Hospital for ChildrenGalvestonTXUSA"},{"name":"Department of SurgeryUniversity of Texas Medical BranchGalvestonTXUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Cotter","sequence":"additional","affiliation":[{"name":"Shriners Hospital for ChildrenGalvestonTXUSA"},{"name":"Department of SurgeryUniversity of Texas Medical BranchGalvestonTXUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon L","family":"Klein","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery and RehabilitationUniversity of Texas Medical BranchGalvestonTXUSA"},{"name":"Shriners Hospital for ChildrenGalvestonTXUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,12,18]]},"reference":[{"key":"2024020318523702700_jbmr2162-bib-0001","article-title":"Preliminary evidence of acute bone resorption in a sheep model of burn injury: an observational study","author":"Klein","year":"2013","journal-title":"J Bone Miner Metab."},{"key":"2024020318523702700_jbmr2162-bib-0002","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/8756-3282(95)00279-1","article-title":"Histomorphometric and biochemical characterization of bone following acute severe burns in children","volume":"17","author":"Klein","year":"1995","journal-title":"Bone."},{"key":"2024020318523702700_jbmr2162-bib-0003","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1007\/s00198-003-1572-3","article-title":"Evidence supporting a role of glucocorticoids in short-term bone loss in burned children","volume":"15","author":"Klein","year":"2004","journal-title":"Osteoporos Int."},{"key":"2024020318523702700_jbmr2162-bib-0004","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1007\/s00198-004-1731-1","article-title":"The efficacy of acute administration of pamidronate on the conservation of bone mass following severe burn injury in children: a double-blind, randomized, controlled study","volume":"16","author":"Klein","year":"2005","journal-title":"Osteoporos Int."},{"key":"2024020318523702700_jbmr2162-bib-0005","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.bone.2007.04.195","article-title":"Pamidronate preserves bone mass for at least 2 years following acute administration for pediatric burn injury","volume":"41","author":"Przkora","year":"2007","journal-title":"Bone."},{"key":"2024020318523702700_jbmr2162-bib-0006","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1007\/s00198-007-0540-8","article-title":"Mechanisms of action of bisphosphonates: similarities and differences and their potential influence on clinical efficacy","volume":"19","author":"Russell","year":"2008","journal-title":"Osteoporos Int."},{"key":"2024020318523702700_jbmr2162-bib-0007","first-page":"51","volume-title":"Isotope tracers in metabolic research","author":"Wolfe","year":"2004"},{"key":"2024020318523702700_jbmr2162-bib-0008","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1097\/00000658-200010000-00001","article-title":"Persistence of muscle catabolism after severe burn","volume":"232","author":"Hart","year":"2000","journal-title":"Ann Surg."},{"key":"2024020318523702700_jbmr2162-bib-0009","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1152\/jappl.2001.91.3.1168","article-title":"Effects of a 12-week resistance exercise program on skeletal muscle strength in children with burn injuries","volume":"91","author":"Suman","year":"2001","journal-title":"J Appl Physiol."},{"key":"2024020318523702700_jbmr2162-bib-0010","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1152\/japplphysiol.00607.2012","article-title":"Impaired exercise capacity and skeletal muscle function in a mouse model of pulmonary inflammation","volume":"114","author":"Tang","year":"2013","journal-title":"J Appl Physiol."},{"key":"2024020318523702700_jbmr2162-bib-0011","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1006\/bbrc.1997.7207","article-title":"Inhibition of PTH secretion by interleukin-1 beta in bovine parathyroid glands in vitro is associated with an up-regulation of the calcium-sensing receptor mRNA","volume":"238","author":"Nielsen","year":"1997","journal-title":"Biochem Biophys Res Comm."},{"key":"2024020318523702700_jbmr2162-bib-0012","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1677\/jme.0.0310609","article-title":"Parathyroid hormone (PTH) secretion, PTH mRNA, and calcium-sensing receptor mRNA expression in bovine parathyroid cells, and effects of interleukin (IL)-1, IL-6, and tumor necrosis factor alpha on equine parathyroid cell function","volume":"31","author":"Toribio","year":"2003","journal-title":"J Mol Endocrinol."},{"key":"2024020318523702700_jbmr2162-bib-0013","doi-asserted-by":"crossref","first-page":"13586","DOI":"10.1074\/jbc.M708087200","article-title":"The pro-inflammatory cytokine, interleukin-t, up-regulates calcium-sensing receptor gene transcription via Stat 1\/3 and Sp 1\/3","volume":"283","author":"Cannaff","year":"2008","journal-title":"J Biol Chem."},{"key":"2024020318523702700_jbmr2162-bib-0014","doi-asserted-by":"crossref","first-page":"3885","DOI":"10.1097\/00003246-200012000-00024","article-title":"Up-regulation of the parathyroid calcium-sensing receptor after burn injury in sheep: a potential contributory factor to post-burn hypocalcemia","volume":"28","author":"Murphey","year":"2000","journal-title":"Crit Care Med."},{"key":"2024020318523702700_jbmr2162-bib-0015","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.ydbio.2011.06.002","article-title":"Growth of limb muscle is dependent on skeletal derived Indian hedgehog","volume":"356","author":"Bren-Mattison","year":"2011","journal-title":"Dev Biol."},{"key":"2024020318523702700_jbmr2162-bib-0016","doi-asserted-by":"crossref","first-page":"e37512","DOI":"10.1371\/journal.pone.0037512","article-title":"Bone marrow mesenchymal stromal cells stimulate skeletal myoblast proliferation through the paracrine release of VEGF","volume":"7","author":"Sassoli","year":"2012","journal-title":"PLoS One."},{"key":"2024020318523702700_jbmr2162-bib-0017","doi-asserted-by":"crossref","first-page":"e35465","DOI":"10.1371\/journal.pone.0035465","article-title":"The effects of ketoconazole on post-burn inflammation, hypermetabolism, and clinical outcomes","volume":"7","author":"Jeschke","year":"2012","journal-title":"PLoS One."},{"key":"2024020318523702700_jbmr2162-bib-0018","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1359\/jbmr.080617","article-title":"Connexin 43 is required for the anti-apoptotic effects of bisphosphonates on osteocytes and osteoblasts in vivo","volume":"23","author":"Plotkin","year":"2008","journal-title":"J Bone Miner Res."}],"container-title":["Journal of Bone and Mineral Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbmr.2162","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/29\/6\/1369\/56565840\/jbmr2162.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/29\/6\/1369\/56565840\/jbmr2162.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T14:51:22Z","timestamp":1710341482000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbmr\/article\/29\/6\/1369-1372\/7598957"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,1]]},"references-count":18,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2014,12,18]]},"published-print":{"date-parts":[[2014,6,1]]}},"URL":"https:\/\/doi.org\/10.1002\/jbmr.2162","relation":{},"ISSN":["0884-0431","1523-4681"],"issn-type":[{"value":"0884-0431","type":"print"},{"value":"1523-4681","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2014,6,1]]},"published":{"date-parts":[[2014,6,1]]}}}