{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T15:44:26Z","timestamp":1792424666268,"version":"4.5.0"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2014,1,14]],"date-time":"2014-01-14T00:00:00Z","timestamp":1389657600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,6,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>\u2003<\/jats:title>\n                  <jats:p>Most fragility fractures arise among the many women with osteopenia, not the smaller number with osteoporosis at high risk for fracture. Thus, most women at risk for fracture assessed only by measuring areal bone mineral density (aBMD) will remain untreated. We measured cortical porosity and trabecular bone volume\/total volume (BV\/TV) of the ultradistal radius (UDR) using high-resolution peripheral quantitative computed tomography, aBMD using densitometry, and 10-year fracture probability using the country-specific fracture risk assessment tool (FRAX) in 68 postmenopausal women with forearm fractures and 70 age-matched community controls in Olmsted County, MN, USA. Women with forearm fractures had 0.4 standard deviations (SD) higher cortical porosity and 0.6 SD lower trabecular BV\/TV. Compact-appearing cortical porosity predicted fracture independent of aBMD; odds ratio (OR)\u2009=\u20091.92 (95% confidence interval [CI] 1.10\u20133.33). In women with osteoporosis at the UDR, cortical porosity did not distinguish those with fractures from those without because high porosity was present in 92% and 86% of each group, respectively. By contrast, in women with osteopenia at the UDR, high porosity of the compact-appearing cortex conferred an OR for fracture of 4.00 (95% CI 1.15\u201313.90). In women with osteoporosis, porosity is captured by aBMD, so measuring UDR cortical porosity does not improve diagnostic sensitivity. However, in women with osteopenia, cortical porosity was associated with forearm fractures. \u00a9 2014 American Society for Bone and Mineral Research.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/jbmr.2167","type":"journal-article","created":{"date-parts":[[2014,1,14]],"date-time":"2014-01-14T08:37:10Z","timestamp":1389688630000},"page":"1356-1362","source":"Crossref","is-referenced-by-count":168,"title":["Cortical Porosity Identifies Women With Osteopenia at Increased Risk for Forearm Fractures"],"prefix":"10.1093","volume":"29","author":[{"given":"Yohann","family":"Bala","sequence":"first","affiliation":[{"name":"Endocrine Center, Austin HealthUniversity of MelbourneMelbourneAustralia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Zebaze","sequence":"additional","affiliation":[{"name":"Endocrine Center, Austin HealthUniversity of MelbourneMelbourneAustralia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Ghasem-Zadeh","sequence":"additional","affiliation":[{"name":"Endocrine Center, Austin HealthUniversity of MelbourneMelbourneAustralia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth J","family":"Atkinson","sequence":"additional","affiliation":[{"name":"College of MedicineMayo ClinicRochesterMNUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Iuliano","sequence":"additional","affiliation":[{"name":"Endocrine Center, Austin HealthUniversity of MelbourneMelbourneAustralia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James M","family":"Peterson","sequence":"additional","affiliation":[{"name":"College of MedicineMayo ClinicRochesterMNUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shreyasee","family":"Amin","sequence":"additional","affiliation":[{"name":"College of MedicineMayo ClinicRochesterMNUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c5shild","family":"Bj\u00f8rnerem","sequence":"additional","affiliation":[{"name":"Department of Health and Care SciencesUiT The Arctic University of NorwayTroms\u00f8Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"L Joseph","family":"Melton","sequence":"additional","affiliation":[{"name":"College of MedicineMayo ClinicRochesterMNUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Johansson","sequence":"additional","affiliation":[{"name":"Consulting statisticianGothenburgSweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A","family":"Kanis","sequence":"additional","affiliation":[{"name":"WHO Collaborating Centre for Metabolic Bone DiseasesUniversity of SheffieldSheffieldUnited Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sundeep","family":"Khosla","sequence":"additional","affiliation":[{"name":"College of MedicineMayo ClinicRochesterMNUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ego","family":"Seeman","sequence":"additional","affiliation":[{"name":"Endocrine Center, Austin HealthUniversity of MelbourneMelbourneAustralia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,1,14]]},"reference":[{"issue":"6","key":"2024020318520056500_jbmr2167-bib-0001","doi-asserted-by":"crossref","first-page":"861","DOI":"10.7326\/0003-4819-27-6-861","article-title":"Osteoporosis","volume":"27","author":"Albright","year":"1947","journal-title":"Ann Intern Med."},{"key":"2024020318520056500_jbmr2167-bib-0002","volume-title":"A treatise on disloctations, and on fractures of the joints","author":"Cooper"},{"issue":"4","key":"2024020318520056500_jbmr2167-bib-0003","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1007\/BF01623921","article-title":"Osteoporosis: the evolution of a scientific term","volume":"2","author":"Schapira","year":"1992","journal-title":"Osteoporos Int."},{"issue":"6","key":"2024020318520056500_jbmr2167-bib-0004","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1007\/BF01622200","article-title":"Assessment of fracture risk and its application to screening for postmenopausal osteoporosis: synopsis of a WHO report. 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