{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T04:09:36Z","timestamp":1789963776273,"version":"4.0.1"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2014,2,12]],"date-time":"2014-02-12T00:00:00Z","timestamp":1392163200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,8,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>\u2003<\/jats:title>\n                  <jats:p>The cathepsin K inhibitor odanacatib (ODN), currently in phase 3 development for postmenopausal osteoporosis, has a novel mechanism of action that reduces bone resorption while maintaining bone formation. In phase 2 studies, odanacatib increased areal bone mineral density (aBMD) at the lumbar spine and total hip progressively over 5 years. To determine the effects of ODN on cortical and trabecular bone and estimate changes in bone strength, we conducted a randomized, double-blind, placebo-controlled trial, using both quantitative computed tomography (QCT) and high-resolution peripheral (HR-p)QCT. In previously published results, odanacatib was superior to placebo with respect to increases in trabecular volumetric BMD (vBMD) and estimated compressive strength at the spine, and integral and trabecular vBMD and estimated strength at the hip. Here, we report the results of HR-pQCT assessment. A total of 214 postmenopausal women (mean age 64.0\u2009\u00b1\u20096.8 years and baseline lumbar spine T-score \u20131.81\u2009\u00b1\u20090.83) were randomized to oral ODN 50\u2009mg or placebo, weekly for 2 years. With ODN, significant increases from baseline in total vBMD occurred at the distal radius and tibia. Treatment differences from placebo were also significant (3.84% and 2.63% for radius and tibia, respectively). At both sites, significant differences from placebo were also found in trabecular vBMD, cortical vBMD, cortical thickness, cortical area, and strength (failure load) estimated using finite element analysis of HR-pQCT scans (treatment differences at radius and tibia\u2009=\u20092.64% and 2.66%). At the distal radius, odanacatib significantly improved trabecular thickness and bone volume\/total volume (BV\/TV) versus placebo. At a more proximal radial site, odanacatib attenuated the increase in cortical porosity found with placebo (treatment difference\u2009=\u2009\u20137.7%, p\u2009=\u20090.066). At the distal tibia, odanacatib significantly improved trabecular number, separation, and BV\/TV versus placebo. Safety and tolerability were similar between treatment groups. In conclusion, odanacatib increased cortical and trabecular density, cortical thickness, aspects of trabecular microarchitecture, and estimated strength at the distal radius and distal tibia compared with placebo. \u00a9 2014 American Society for Bone and Mineral Research<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/jbmr.2194","type":"journal-article","created":{"date-parts":[[2014,2,12]],"date-time":"2014-02-12T12:33:12Z","timestamp":1392208392000},"page":"1786-1794","source":"Crossref","is-referenced-by-count":59,"title":["Effects of Odanacatib on the Radius and Tibia of Postmenopausal Women: Improvements in Bone Geometry, Microarchitecture, and Estimated Bone Strength"],"prefix":"10.1093","volume":"29","author":[{"given":"Angela M","family":"Cheung","sequence":"first","affiliation":[{"name":"University of TorontoOntarioCanada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharmila","family":"Majumdar","sequence":"additional","affiliation":[{"name":"University of CaliforniaSan FranciscoCAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Brixen","sequence":"additional","affiliation":[{"name":"University of Southern DenmarkOdenseDenmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Chapurlat","sequence":"additional","affiliation":[{"name":"INSERMLyonFrance"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Fuerst","sequence":"additional","affiliation":[{"name":"Synarc, Inc.NewarkCAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Engelke","sequence":"additional","affiliation":[{"name":"Synarc, Inc.HamburgGermany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Dardzinski","sequence":"additional","affiliation":[{"name":"Children's HospitalThe University of PennsylvaniaPhiladelphiaPAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Cabal","sequence":"additional","affiliation":[{"name":"Merck Sharp & DohmeWhitehouse StationNJUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Verbruggen","sequence":"additional","affiliation":[{"name":"Merck Sharp & DohmeBrusselsBelgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shabana","family":"Ather","sequence":"additional","affiliation":[{"name":"Merck Sharp & DohmeWhitehouse StationNJUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Rosenberg","sequence":"additional","affiliation":[{"name":"Merck Sharp & DohmeWhitehouse StationNJUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne E","family":"de Papp","sequence":"additional","affiliation":[{"name":"Merck Sharp & DohmeWhitehouse StationNJUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,2,12]]},"reference":[{"key":"2024020318503589400_jbmr2194-bib-0001","first-page":"799","article-title":"Odanacatib, a cathepsin K inhibitor for the treatment of osteoporosis and other skeletal disorders associated with excessive bone remodeling","volume":"12","author":"Lewiecki","year":"2009","journal-title":"IDrugs"},{"key":"2024020318503589400_jbmr2194-bib-0002","volume-title":"Bone health and osteoporosis: a report of the surgeon general","author":"US Department of Health and Human Services","year":"2004"},{"key":"2024020318503589400_jbmr2194-bib-0003","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1016\/S0140-6736(06)68891-0","volume":"367","author":"Sambrook","year":"2006","journal-title":"Osteoporosis. 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