{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T10:52:44Z","timestamp":1789901564986,"version":"4.0.1"},"reference-count":57,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2014,2,12]],"date-time":"2014-02-12T00:00:00Z","timestamp":1392163200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,7,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>\u2003<\/jats:title>\n                  <jats:p>We previously demonstrated that skeletal mass, structure, and biomechanical properties vary considerably in heterogeneous stock (HS) rat strains. In addition, we observed strong heritability for several of these skeletal phenotypes in the HS rat model, suggesting that it represents a unique genetic resource for dissecting the complex genetics underlying bone fragility. The purpose of this study was to identify and localize genes associated with bone mineral density in HS rats. We measured bone phenotypes from 1524 adult male and female HS rats between 17 and 20 weeks of age. Phenotypes included dual-energy X-ray absorptiometry (DXA) measurements for bone mineral content and areal bone mineral density (aBMD) for femur and lumbar spine (L3\u2013L5), and volumetric BMD measurements by CT for the midshaft and distal femur, femur neck, and fifth lumbar vertebra (L5). A total of 70,000 polymorphic single-nucleotide polymorphisms (SNPs) distributed throughout the genome were selected from genotypes obtained from the Affymetrix rat custom SNPs array for the HS rat population. These SNPs spanned the HS rat genome with a mean linkage disequilibrium coefficient between neighboring SNPs of 0.95. Haplotypes were estimated across the entire genome for each rat using a multipoint haplotype reconstruction method, which calculates the probability of descent for each genotyped locus from each of the eight founder HS strains. The haplotypes were tested for association with each bone density phenotype via a mixed model with covariate adjustment. We identified quantitative trait loci (QTLs) for BMD phenotypes on chromosomes 2, 9, 10, and 13 meeting a conservative genomewide empiric significance threshold (false discovery rate [FDR]\u2009=\u20095%; p\u2009&amp;lt;\u20093\u2009\u00d7\u200910\u22126). Importantly, most QTLs were localized to very small genomic regions (1\u20133 megabases [Mb]), allowing us to identify a narrow set of potential candidate genes including both novel genes and genes previously shown to have roles in skeletal development and homeostasis. \u00a9 2014 American Society for Bone and Mineral Research.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/jbmr.2195","type":"journal-article","created":{"date-parts":[[2014,2,12]],"date-time":"2014-02-12T12:34:10Z","timestamp":1392208450000},"page":"1619-1626","source":"Crossref","is-referenced-by-count":9,"title":["High-Resolution Genome Screen for Bone Mineral Density in Heterogeneous Stock Rat"],"prefix":"10.1093","volume":"29","author":[{"given":"Imranul","family":"Alam","sequence":"first","affiliation":[{"name":"Department of MedicineIndiana University School of MedicineINUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel L","family":"Koller","sequence":"additional","affiliation":[{"name":"Department of Medical and Molecular GeneticsIndiana University School of MedicineINUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toni","family":"Ca\u00f1ete","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Forensic MedicineInstitute of Neurosciences, School of Medicine, Universitat Aut\u00f2noma de BarcelonaBarcelonaSpain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria","family":"Bl\u00e1zquez","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Forensic MedicineInstitute of Neurosciences, School of Medicine, Universitat Aut\u00f2noma de BarcelonaBarcelonaSpain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regina","family":"L\u00f3pez-Aumatell","sequence":"additional","affiliation":[{"name":"Wellcome Trust Center for Human GeneticsOxfordUK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Mart\u00ednez-Membrives","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Forensic MedicineInstitute of Neurosciences, School of Medicine, Universitat Aut\u00f2noma de BarcelonaBarcelonaSpain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sira","family":"D\u00edaz-Mor\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Forensic MedicineInstitute of Neurosciences, School of Medicine, Universitat Aut\u00f2noma de BarcelonaBarcelonaSpain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adolf","family":"Tobe\u00f1a","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Forensic MedicineInstitute of Neurosciences, School of Medicine, Universitat Aut\u00f2noma de BarcelonaBarcelonaSpain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Fern\u00e1ndez-Teruel","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Forensic MedicineInstitute of Neurosciences, School of Medicine, Universitat Aut\u00f2noma de BarcelonaBarcelonaSpain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pernilla","family":"Stridh","sequence":"additional","affiliation":[{"name":"Clinical NeuroscienceCenter for Molecular Medicine, Neuroimmunolgy Unit, Karolinska InstitutetStockholmSweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarita","family":"Diez","sequence":"additional","affiliation":[{"name":"Clinical NeuroscienceCenter for Molecular Medicine, Neuroimmunolgy Unit, Karolinska InstitutetStockholmSweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Olsson","sequence":"additional","affiliation":[{"name":"Clinical NeuroscienceCenter for Molecular Medicine, Neuroimmunolgy Unit, Karolinska InstitutetStockholmSweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Johannesson","sequence":"additional","affiliation":[{"name":"Clinical NeuroscienceCenter for Molecular Medicine, Neuroimmunolgy Unit, Karolinska InstitutetStockholmSweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amelie","family":"Baud","sequence":"additional","affiliation":[{"name":"Wellcome Trust Center for Human GeneticsOxfordUK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J","family":"Econs","sequence":"additional","affiliation":[{"name":"Department of Medical and Molecular GeneticsIndiana University School of MedicineINUSA"},{"name":"Department of MedicineIndiana University School of MedicineINUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana","family":"Foroud","sequence":"additional","affiliation":[{"name":"Department of Medical and Molecular GeneticsIndiana University School of MedicineINUSA"},{"name":"Department of MedicineIndiana University School of MedicineINUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,2,12]]},"reference":[{"key":"2024020318515299100_jbmr2195-bib-0001","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1002\/jbmr.5650090802","article-title":"The diagnosis of osteoporosis","volume":"9","author":"Kanis","year":"1994","journal-title":"J Bone Miner Res."},{"key":"2024020318515299100_jbmr2195-bib-0002","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/0140-6736(93)92555-8","article-title":"Bone density at various sites for prediction of hip fractures. The Study of Osteoporotic Fractures Research Group","volume":"341","author":"Cummings","year":"1993","journal-title":"Lancet."},{"key":"2024020318515299100_jbmr2195-bib-0003","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1002\/jbmr.5650081008","article-title":"Simple measurement of femoral geometry predicts hip fracture: the study of osteoporotic fractures","volume":"8","author":"Faulkner","year":"1993","journal-title":"J Bone Miner Res."},{"key":"2024020318515299100_jbmr2195-bib-0004","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/BF02106096","article-title":"Johnston CC Jr. Better discrimination of hip fracture using bone density, geometry and architecture","volume":"5","author":"Peacock","year":"1995","journal-title":"Osteoporos Int."},{"key":"2024020318515299100_jbmr2195-bib-0005","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1002\/jbmr.5650110414","article-title":"The heritability of bone mineral density, ultrasound of the calcaneus and hip axis length: a study of postmenopausal twins","volume":"11","author":"Arden","year":"1996","journal-title":"J Bone Miner Res."},{"key":"2024020318515299100_jbmr2195-bib-0006","first-page":"140","article-title":"Genetic influence on bone turnover in postmenopausal twins","volume":"81","author":"Garnero","year":"1996","journal-title":"J Clin Endocrinol Metab."},{"key":"2024020318515299100_jbmr2195-bib-0007","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1210\/edrv.23.3.0464","article-title":"Genetics of osteoporosis","volume":"23","author":"Peacock","year":"2002","journal-title":"Endocr Rev."},{"key":"2024020318515299100_jbmr2195-bib-0008","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1097\/01.bor.0000166385.62851.92","article-title":"Genetic determinants of osteoporosis","volume":"17","author":"Ralston","year":"2005","journal-title":"Curr Opin Rheumatol."},{"key":"2024020318515299100_jbmr2195-bib-0009","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1359\/jbmr.080221","article-title":"Sex-specific genetic loci for femoral neck bone mass and strength identified in inbred COP and DA rats","volume":"23","author":"Alam","year":"2008","journal-title":"J Bone Miner Res."},{"key":"2024020318515299100_jbmr2195-bib-0010","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.bone.2007.11.004","article-title":"Genetic loci affecting bone structure and strength in inbred COP and DA rats","volume":"42","author":"Sun","year":"2008","journal-title":"Bone."},{"key":"2024020318515299100_jbmr2195-bib-0011","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.bone.2005.12.009","article-title":"Identification of a quantitative trait locus on rat chromosome 4 that is strongly linked to femoral neck structure and strength","volume":"39","author":"Alam","year":"2006","journal-title":"Bone."},{"key":"2024020318515299100_jbmr2195-bib-0012","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1359\/JBMR.050512","article-title":"Whole-genome scan for linkage to bone strength and structure in inbred Fischer 344 and Lewis rats","volume":"20","author":"Alam","year":"2005","journal-title":"J Bone Miner Res."},{"key":"2024020318515299100_jbmr2195-bib-0013","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1007\/s00335-004-2459-0","article-title":"Genome screen for bone mineral density phenotypes in Fischer 344 and Lewis rats","volume":"16","author":"Koller","year":"2005","journal-title":"Mamm Genome."},{"key":"2024020318515299100_jbmr2195-bib-0014","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s10142-009-0147-6","article-title":"Genes influencing spinal bone mineral density in inbred F344, LEW, COP and DA rats","volume":"10","author":"Alam","year":"2009","journal-title":"Funct Integr Genomics."},{"key":"2024020318515299100_jbmr2195-bib-0015","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.ygeno.2009.05.008","article-title":"Differentially expressed genes strongly correlated with femur strength in rats","volume":"94","author":"Alam","year":"2009","journal-title":"Genomics."},{"key":"2024020318515299100_jbmr2195-bib-0016","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1152\/physiolgenomics.90237.2008","article-title":"Genomic expression analysis of rat chromosome 4 for skeletal traits at femoral neck","volume":"35","author":"Alam","year":"2008","journal-title":"Physiol Genomics."},{"key":"2024020318515299100_jbmr2195-bib-0017","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1111\/j.1530-0277.1984.tb05706.x","article-title":"Development of the National Institutes of Health genetically heterogeneous rat stock","volume":"8","author":"Hansen","year":"1984","journal-title":"Alcohol Clin Exp Res."},{"key":"2024020318515299100_jbmr2195-bib-0018","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/BF00178778","article-title":"On the classification of regular systems of inbreeding","volume":"28","author":"Boucher","year":"1990","journal-title":"J Math Biol."},{"key":"2024020318515299100_jbmr2195-bib-0019","doi-asserted-by":"crossref","first-page":"12649","DOI":"10.1073\/pnas.230304397","article-title":"A method for fine mapping quantitative trait loci in outbred animal stocks","volume":"97","author":"Mott","year":"2000","journal-title":"Proc Natl Acad Sci U S A."},{"key":"2024020318515299100_jbmr2195-bib-0020","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1152\/physiolgenomics.00178.2009","article-title":"Fine-mapping a locus for glucose tolerance using heterogeneous stock rats","volume":"41","author":"Solberg Woods","year":"2010","journal-title":"Physiol Genomics."},{"key":"2024020318515299100_jbmr2195-bib-0021","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1101\/gr.081497.108","article-title":"A resource for the simultaneous high-resolution mapping of multiple quantitative trait loci in rats: the NIH heterogeneous stock","volume":"19","author":"Johannesson","year":"2009","journal-title":"Genome Res."},{"key":"2024020318515299100_jbmr2195-bib-0022","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/j.bone.2011.02.009","article-title":"Heterogeneous stock rat: A unique animal model for mapping genes influencing bone fragility","volume":"48","author":"Alam","year":"2011","journal-title":"Bone."},{"issue":"7","key":"2024020318515299100_jbmr2195-bib-0023","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1038\/ng.2644","article-title":"Combined sequence-based and genetic mapping analysis of complex traits in outbred rats","volume":"45","author":"Baud","year":"2013","journal-title":"Nat Genet."},{"issue":"3","key":"2024020318515299100_jbmr2195-bib-0024","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1534\/genetics.107.080101","article-title":"Efficient control of population structure in model organism association mapping","volume":"178","author":"Kang","year":"2008","journal-title":"Genetics."},{"key":"2024020318515299100_jbmr2195-bib-0025","author":"R Development Core Team","year":"2004"},{"issue":"2","key":"2024020318515299100_jbmr2195-bib-0026","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1093\/genetics\/143.2.1013","article-title":"Confidence intervals in QTL mapping by bootstrapping","volume":"143","author":"Visscher","year":"1996","journal-title":"Genetics."},{"issue":"10","key":"2024020318515299100_jbmr2195-bib-0027","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1515\/BC.2011.080","article-title":"Lack of ADAM15 in mice is associated with increased osteoblast function and bone mass","volume":"392","author":"Marzia","year":"2011","journal-title":"Biol Chem."},{"issue":"2","key":"2024020318515299100_jbmr2195-bib-0028","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1006\/excr.1997.3550","article-title":"The calpain-calpastatin system and cellular proliferation and differentiation in rodent osteoblastic cells","volume":"233","author":"Murray","year":"1997","journal-title":"Exp Cell Res."},{"issue":"14","key":"2024020318515299100_jbmr2195-bib-0029","doi-asserted-by":"crossref","first-page":"9745","DOI":"10.1074\/jbc.M513516200","article-title":"Calpain is required for normal osteoclast function and is down-regulated by calcitonin","volume":"281","author":"Marzia","year":"2006","journal-title":"J Biol Chem."},{"issue":"11","key":"2024020318515299100_jbmr2195-bib-0030","doi-asserted-by":"crossref","first-page":"2799","DOI":"10.1128\/MCB.00157-10","article-title":"Targeted deletion of Capn4 in cells of the chondrocyte lineage impairs chondrocyte proliferation and differentiation","volume":"30","author":"Kashiwagi","year":"2010","journal-title":"Mol Cell Biol."},{"issue":"4","key":"2024020318515299100_jbmr2195-bib-0031","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1002\/jbmr.2084","article-title":"EphA4 receptor is a novel negative regulator of osteoclast activity","volume":"29","author":"Stiffel","year":"2014","journal-title":"J Bone Miner Res."},{"issue":"5","key":"2024020318515299100_jbmr2195-bib-0032","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1242\/dev.028605","article-title":"EphA4 as an effector of Twist1 in the guidance of osteogenic precursor cells during calvarial bone growth and in craniosynostosis","volume":"136","author":"Ting","year":"2009","journal-title":"Development."},{"issue":"2","key":"2024020318515299100_jbmr2195-bib-0033","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.cyto.2008.05.007","article-title":"IL-6 receptor expression and IL-6 effects change during osteoblast differentiation","volume":"43","author":"Li","year":"2008","journal-title":"Cytokine."},{"issue":"1","key":"2024020318515299100_jbmr2195-bib-0034","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/S8756-3282(02)00806-2","article-title":"Expression of leukemia inhibitory factor (LIF)\/interleukin-6 family cytokines and receptors during in vitro osteogenesis: differential regulation by dexamethasone and LIF","volume":"31","author":"Liu","year":"2002","journal-title":"Bone."},{"issue":"6","key":"2024020318515299100_jbmr2195-bib-0035","doi-asserted-by":"crossref","first-page":"3353","DOI":"10.4049\/jimmunol.169.6.3353","article-title":"IL-6, leukemia inhibitory factor, and oncostatin M stimulate bone resorption and regulate the expression of receptor activator of NF-kappa B ligand, osteoprotegerin, and receptor activator of NF-kappa B in mouse calvariae","volume":"169","author":"Palmqvist","year":"2002","journal-title":"J Immunol."},{"issue":"8","key":"2024020318515299100_jbmr2195-bib-0036","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1093\/hmg\/ddi085","article-title":"Inactivation of Rai1 in mice recapitulates phenotypes observed in chromosome engineered mouse models for Smith-Magenis syndrome","volume":"14","author":"Bi","year":"2005","journal-title":"Hum Mol Genet."},{"key":"2024020318515299100_jbmr2195-bib-0037","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1146\/annurev.genom.9.081307.164437","article-title":"Transcriptional control of skeletogenesis","volume":"9","author":"Karsenty","year":"2008","journal-title":"Annu Rev Genomics Hum Genet."},{"issue":"13","key":"2024020318515299100_jbmr2195-bib-0038","doi-asserted-by":"crossref","first-page":"5599","DOI":"10.1128\/MCB.25.13.5599-5606.2005","article-title":"Mice with a disruption of the thrombospondin 3 gene differ in geometric and biomechanical properties of bone and have accelerated development of the femoral head","volume":"25","author":"Hankenson","year":"2005","journal-title":"Mol Cell Biol."},{"issue":"4","key":"2024020318515299100_jbmr2195-bib-0039","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1002\/jcb.20462","article-title":"Vascular endothelial growth factor (VEGF-A) expression in human mesenchymal stem cells: autocrine and paracrine role on osteoblastic and endothelial differentiation","volume":"95","author":"Mayer","year":"2005","journal-title":"J Cell Biochem."},{"issue":"9","key":"2024020318515299100_jbmr2195-bib-0040","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1242\/dev.01053","article-title":"VEGFA is necessary for chondrocyte survival during bone development","volume":"131","author":"Zelzer","year":"2004","journal-title":"Development."},{"issue":"2","key":"2024020318515299100_jbmr2195-bib-0041","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1002\/stem.581","article-title":"Locally applied VEGFA increases the osteogenic healing capacity of human adipose derived stem cells by promoting osteogenic and endothelial differentiation","volume":"29","author":"Behr","year":"2011","journal-title":"Stem Cells."},{"issue":"4","key":"2024020318515299100_jbmr2195-bib-0042","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/j.bone.2006.04.031","article-title":"Tropomyosin isoforms localize to distinct microfilament populations in osteoclasts","volume":"39","author":"McMichael","year":"2006","journal-title":"Bone."},{"issue":"1","key":"2024020318515299100_jbmr2195-bib-0043","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/j.1469-1809.2008.00490.x","article-title":"Association of a polymorphism in the intron 7 of the SREBF1 gene with osteonecrosis of the femoral head in Koreans","volume":"73","author":"Lee","year":"2009","journal-title":"Ann Hum Genet."},{"issue":"3","key":"2024020318515299100_jbmr2195-bib-0044","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.bone.2005.04.035","article-title":"Expression of the zinc transporter ZIP1 in osteoclasts","volume":"37","author":"Khadeer","year":"2005","journal-title":"Bone."},{"issue":"2","key":"2024020318515299100_jbmr2195-bib-0045","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.bone.2005.08.010","article-title":"Overexpression of the ZIP1 zinc transporter induces an osteogenic phenotype in mesenchymal stem cells","volume":"38","author":"Tang","year":"2006","journal-title":"Bone."},{"key":"2024020318515299100_jbmr2195-bib-0046","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1359\/jbmr.2003.18.8.1531","article-title":"Site and gender specificity of inheritance of bone mineral density","volume":"18","author":"Duncan","year":"2003","journal-title":"J Bone Miner Res."},{"issue":"2","key":"2024020318515299100_jbmr2195-bib-0047","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1359\/jbmr.060806","article-title":"Meta-analysis of genome-wide scans provides evidence for sex- and site-specific regulation of bone mass","volume":"22","author":"Ioannidis","year":"2007","journal-title":"J Bone Miner Res."},{"issue":"9","key":"2024020318515299100_jbmr2195-bib-0048","first-page":"3116","article-title":"Genome screen for QTLs contributing to normal variation in bone mineral density and osteoporosis","volume":"85","author":"Koller","year":"2000","journal-title":"J Clin Endocrinol Metab."},{"issue":"5","key":"2024020318515299100_jbmr2195-bib-0049","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1006\/geno.2002.6760","article-title":"Genetic dissection of femur breaking strength in a large population (MRL\/MpJ \u00d7 SJL\/J) of F2 Mice: single QTL effects, epistasis, and pleiotropy","volume":"79","author":"Li","year":"2002","journal-title":"Genomics."},{"issue":"5","key":"2024020318515299100_jbmr2195-bib-0050","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s00223-001-1113-z","article-title":"Quantitative trait loci for bone density in mice: the genes determining total skeletal density and femur density show little overlap in F2 mice","volume":"71","author":"Masinde","year":"2002","journal-title":"Calcif Tissue Int."},{"issue":"9","key":"2024020318515299100_jbmr2195-bib-0051","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1359\/jbmr.2002.17.9.1718","article-title":"Genome screen for quantitative trait loci contributing to normal variation in bone mineral density: the Framingham Study","volume":"17","author":"Karasik","year":"2002","journal-title":"J Bone Miner Res."},{"issue":"6","key":"2024020318515299100_jbmr2195-bib-0052","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1086\/302685","article-title":"Stratification analysis of an osteoarthritis genome screen-suggestive linkage to chromosomes 4, 6 and 16","volume":"65","author":"Loughlin","year":"1999","journal-title":"Am J Hum Genet."},{"issue":"4","key":"2024020318515299100_jbmr2195-bib-0053","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1086\/319518","article-title":"A genomewide screen in multiplex rheumatoid arthritis families suggests genetic overlap with other autoimmune diseases","volume":"68","author":"Jawaheer","year":"2001","journal-title":"Am J Hum Genet."},{"issue":"3","key":"2024020318515299100_jbmr2195-bib-0054","first-page":"232","article-title":"Genetic regulation of bone mineral density in mice","volume":"2","author":"Klein","year":"2002","journal-title":"J Musculoskelet Neuronal Interact."},{"issue":"7","key":"2024020318515299100_jbmr2195-bib-0055","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1359\/jbmr.2001.16.7.1195","article-title":"Quantitative trait loci for femoral and lumbar vertebral bone mineral density in C57BL\/6J and C3H\/HeJ inbred strains of mice","volume":"16","author":"Beamer","year":"2001","journal-title":"J Bone Miner Res."},{"issue":"1","key":"2024020318515299100_jbmr2195-bib-0056","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.cancergencyto.2004.03.007","article-title":"Amplification and overexpression of genes in 17p11.2 \u223c p12 in osteosarcoma","volume":"153","author":"van Dartel","year":"2004","journal-title":"Cancer Genet Cytogenet."},{"issue":"5","key":"2024020318515299100_jbmr2195-bib-0057","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1136\/jmg.34.5.414","article-title":"Chromosome 18q22.2-- &gt; qter deletion and a congenital anomaly syndrome with multiple vertebral segmentation defects","volume":"34","author":"Dowton","year":"1997","journal-title":"J Med Genet."}],"container-title":["Journal of Bone and Mineral Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbmr.2195","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/29\/7\/1619\/56566415\/jbmr2195.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/29\/7\/1619\/56566415\/jbmr2195.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T14:51:38Z","timestamp":1710341498000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbmr\/article\/29\/7\/1619-1626\/7599033"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,12]]},"references-count":57,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2014,2,12]]},"published-print":{"date-parts":[[2014,7,1]]}},"URL":"https:\/\/doi.org\/10.1002\/jbmr.2195","relation":{},"ISSN":["0884-0431","1523-4681"],"issn-type":[{"value":"0884-0431","type":"print"},{"value":"1523-4681","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2014,7,1]]},"published":{"date-parts":[[2014,2,12]]}}}