{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T22:10:13Z","timestamp":1762899013886},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2014,3,18]],"date-time":"2014-03-18T00:00:00Z","timestamp":1395100800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,9,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>\u2003<\/jats:title>\n                  <jats:p>Fracture healing is an active process with early changes in bone and inflammation. We performed an exploratory study evaluating the association between early changes in densitometric, structural, biomechanical, and biochemical bone parameters during the first weeks of fracture healing and wrist-specific pain and disability at 12 weeks in postmenopausal women with a conservatively treated distal radius fracture. Eighteen patients (aged 64\u2009\u00b1\u20098 years) were evaluated at 1 to 2 and 3 to 4 weeks postfracture, using high-resolution peripheral quantitative computed tomography (HR-pQCT), micro-finite element analysis, serum procollagen type-I N-terminal propeptide (P1NP), carboxy-terminal telopeptide of type I collagen (ICTP), and high-sensitive C-reactive protein (hsCRP). After 12 weeks, patients rated their pain and disability using Patient Rated Wrist Evaluation (PRWE) questionnaire. Additionally, Quick Disability of the Arm Shoulder and Hand (QuickDASH) questionnaire and active wrist range of motion was evaluated. Linear regression models were used to study the relationship between changes in bone parameters and in hsCRP from visit 1 to 2 and PRWE score after 12 weeks. A lower PRWE outcome, indicating better outcome, was significantly related to an early increase in trabecular bone mineral density (BMD) (\u03b2 \u22120.96 [95% CI \u22121.75 to \u22120.16], R2\u2009=\u20090.37), in torsional stiffness (\u22120.14 [\u22120.28 to \u22120.004], R2\u2009=\u20090.31), and to an early decrease in trabecular separation (209 [15 to 402], R2\u2009=\u20090.33) and in ICTP (12.1 [0.0 to 24.1], R2\u2009=\u20090.34). Similar results were found for QuickDASH. Higher total dorsal and palmar flexion range of motion was significantly related to early increase in hsCRP (9.62 [3.90 to 15.34], R2\u2009=\u20090.52). This exploratory study indicates that the assessment of early changes in trabecular BMD, trabecular separation, calculated torsional stiffness, bone resorption marker ICTP, and hsCRP after a distal radius fracture provides valuable information regarding the 12-week clinical outcome in terms of pain, disability, and range of motion and validates its use in studies on the process of early fracture healing. \u00a9 2014 American Society for Bone and Mineral Research.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/jbmr.2225","type":"journal-article","created":{"date-parts":[[2014,3,18]],"date-time":"2014-03-18T12:40:45Z","timestamp":1395146445000},"page":"2065-2073","source":"Crossref","is-referenced-by-count":23,"title":["Early Changes in Bone Density, Microarchitecture, Bone Resorption, and Inflammation Predict the Clinical Outcome 12 Weeks After Conservatively Treated Distal Radius Fractures: An Exploratory Study"],"prefix":"10.1093","volume":"29","author":[{"given":"Ursina","family":"Meyer","sequence":"first","affiliation":[{"name":"Centre on Aging and MobilityUniversity of ZurichZurichSwitzerland"},{"name":"Research School NUTRIMMaastricht UniversityMaastrichtThe Netherlands"},{"name":"Department of Human Movement SciencesMaastricht UniversityMaastrichtThe Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joost J","family":"de Jong","sequence":"additional","affiliation":[{"name":"Department of Internal MedicineMaastricht University Medical CenterMaastrichtThe Netherlands"},{"name":"Research School NUTRIMMaastricht UniversityMaastrichtThe Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandrine GP","family":"Bours","sequence":"additional","affiliation":[{"name":"Department of Internal MedicineMaastricht University Medical CenterMaastrichtThe Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e1s P","family":"Keszei","sequence":"additional","affiliation":[{"name":"Department of Medical InformaticsRWTH Aachen UniversityAachenGermany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacobus J","family":"Arts","sequence":"additional","affiliation":[{"name":"Department of Family MedicineMaastricht UniversityMaastrichtThe Netherlands"},{"name":"Research School CAPHRIMaastricht UniversityMaastrichtThe Netherlands"},{"name":"Department of Orthopaedic SurgeryMaastricht University Medical CenterMaastrichtThe Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter RG","family":"Brink","sequence":"additional","affiliation":[{"name":"Department of Trauma SurgeryMaastricht University Medical CenterMaastrichtThe Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Menheere","sequence":"additional","affiliation":[{"name":"Central Diagnostic LaboratoryMaastricht University Medical CenterMaastrichtThe Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tineke ACM","family":"van Geel","sequence":"additional","affiliation":[{"name":"Department of Family MedicineMaastricht UniversityMaastrichtThe Netherlands"},{"name":"Research School CAPHRIMaastricht UniversityMaastrichtThe Netherlands"},{"name":"Research School NUTRIMMaastricht UniversityMaastrichtThe Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bert","family":"van Rietbergen","sequence":"additional","affiliation":[{"name":"Department of Biomedical EngineeringEindhoven University of TechnologyEindhovenThe Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joop PW","family":"van den Bergh","sequence":"additional","affiliation":[{"name":"Department of Internal MedicineViecuri Medical Center VenloVenloThe Netherlands"},{"name":"Biomedical Research CenterHasselt UniversityHasseltBelgium"},{"name":"Research School NUTRIMMaastricht UniversityMaastrichtThe Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piet P","family":"Geusens","sequence":"additional","affiliation":[{"name":"Department of RheumatologyMaastricht University Medical CenterMaastrichtThe Netherlands"},{"name":"Biomedical Research CenterHasselt UniversityHasseltBelgium"},{"name":"Research School CAPHRIMaastricht UniversityMaastrichtThe Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul C","family":"Willems","sequence":"additional","affiliation":[{"name":"Research School CAPHRIMaastricht UniversityMaastrichtThe Netherlands"},{"name":"Department of Orthopaedic SurgeryMaastricht University Medical CenterMaastrichtThe Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2014,3,18]]},"reference":[{"issue":"12","key":"2024020318485868000_jbmr2225-bib-0001","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1007\/s00198-006-0172-4","article-title":"An 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