{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T11:20:58Z","timestamp":1789989658397,"version":"4.0.1"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2014,6,23]],"date-time":"2014-06-23T00:00:00Z","timestamp":1403481600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,12,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>\u2003<\/jats:title>\n                  <jats:p>Human studies suggest that oxidative stress is a risk factor for osteoporosis, but its relationship with fracture risk is poorly understood. The purpose of the present study was to investigate the association between biomarkers of oxidative stress and hip fracture in postmenopausal women. We conducted a prospective study in the Nurses' Health Study among 996 women aged 60 years or older at baseline blood collection in 1989\u20131990. Plasma fluorescent oxidation products (FlOPs) were measured at three excitation\/emission wavelengths (360\/420\u2009nm named as FlOP_360; 320\/420\u2009nm named as FlOP_320; and 400\/475\u2009nm named as FlOP_400). FlOPs are generated from many different pathways (lipid, protein, and DNA) and reflect a global oxidation burden. FlOP assay is 10\u2013100 times more sensitive than measurement of malondialdehyde. We used Cox proportional hazards regression model to investigate the association between baseline plasma FlOPs and the risk of hip fracture, adjusting for multiple hip fracture risk factors such as age, history of osteoporosis, history of hypertension, prior fracture, and smoking status. Forty-four hip fractures (4.4%) were identified during the follow-up (maximum\u2009=\u200923 years). In the multivariable model, the hazard ratios (HRs) of hip fracture in the second and third tertiles of FlOP_320 were 2.11 (95% confidence interval [CI]\u2009=\u20090.88\u20135.10) and 2.67 (95% CI\u2009=\u20091.14\u20136.27), respectively, in comparison with the lowest tertile, and the risk increased linearly with increasing FlOP_320 (p for trend\u2009=\u20090.021). Neither FlOP_360 nor FlOP_400 was significantly associated with risk of hip fracture (tertile 3 versus tertile 1: HR\u2009=\u20090.70, 95% CI\u2009=\u20090.32\u20131.54, p for trend\u2009=\u20090.386 for FlOP_360; and HR\u2009=\u20090.88, 95% CI\u2009=\u20090.40\u20131.96, p for trend\u2009=\u20090.900 for FlOP_400). In this prospective study, higher plasma FlOP_320 was an independent risk factor for hip fracture. Our results need further confirmation. \u00a9 2014 American Society for Bone and Mineral Research.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/jbmr.2302","type":"journal-article","created":{"date-parts":[[2014,6,24]],"date-time":"2014-06-24T06:02:35Z","timestamp":1403589755000},"page":"2577-2583","source":"Crossref","is-referenced-by-count":49,"title":["Association Between Global Biomarkers of Oxidative Stress and Hip Fracture in Postmenopausal Women: A Prospective Study"],"prefix":"10.1093","volume":"29","author":[{"given":"Shuman","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Environmental Health, Division of Epidemiology and BiostatisticsUniversity of Cincinnati Medical CenterCincinnatiOHUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane","family":"Feskanich","sequence":"additional","affiliation":[{"name":"The Channing Division of Network Medicine, Department of Medicine, Brigham and Women's HospitalHarvard Medical SchoolBostonMAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter C","family":"Willett","sequence":"additional","affiliation":[{"name":"The Channing Division of Network Medicine, Department of Medicine, Brigham and Women's HospitalHarvard Medical SchoolBostonMAUSA"},{"name":"Departments of Nutrition and EpidemiologyHarvard School of Public HealthBostonMAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A Heather","family":"Eliassen","sequence":"additional","affiliation":[{"name":"The Channing Division of Network Medicine, Department of Medicine, Brigham and Women's HospitalHarvard Medical SchoolBostonMAUSA"},{"name":"Department of EpidemiologyHarvard School of Public HealthBostonMAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianying","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Environmental Health, Division of Epidemiology and BiostatisticsUniversity of Cincinnati Medical CenterCincinnatiOHUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,6,23]]},"reference":[{"issue":"5","key":"2024020318461204800_jbmr2302-bib-0001","doi-asserted-by":"crossref","first-page":"479","DOI":"10.2143\/AC.59.5.2005219","article-title":"Oxidized LDL and coronary heart disease","volume":"59","author":"Holvoet","year":"2004","journal-title":"Acta Cardiol."},{"issue":"8","key":"2024020318461204800_jbmr2302-bib-0002","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1373\/clinchem.2011.165134","article-title":"Oxidized LDL and the risk of coronary heart disease: results from the MONICA\/KORA Augsburg Study","volume":"57","author":"Koenig","year":"2011","journal-title":"Clin Chem."},{"issue":"4","key":"2024020318461204800_jbmr2302-bib-0003","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/S0025-6196(12)64862-9","article-title":"Free radicals in medicine. 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