{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T15:21:55Z","timestamp":1790781715776,"version":"4.1.0"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2014,8,12]],"date-time":"2014-08-12T00:00:00Z","timestamp":1407801600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"German Research Foundation BU","award":["2562\/2-1 BU"],"award-info":[{"award-number":["2562\/2-1 BU"]}]},{"name":"German Research Foundation BU","award":["2562\/1-1"],"award-info":[{"award-number":["2562\/1-1"]}]},{"DOI":"10.13039\/100006235","name":"Lawrence Berkeley National Laboratory","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100006235","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,2,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>\u2003<\/jats:title>\n                    <jats:p>Paget's disease of bone (PDB) is the second most common bone disease mostly developing after 50 years of age at one or more localized skeletal sites; it is associated with severely high bone turnover, bone enlargement, bowing\/deformity, cracking, and pain. Here, to specifically address the origins of the deteriorated mechanical integrity, we use a cohort of control and PDB human biopsies to investigate multiscale architectural and compositional modifications to the bone structure (ie, bone quality) and relate these changes to mechanical property measurements to provide further insight into the clinical manifestations (ie, deformities and bowing) and fracture risk caused by PDB. Here, at the level of the collagen and mineral (ie, nanometer-length scale), we find a 19% lower mineral content and lower carbonate-to-phosphate ratio in PDB, which accounts for the 14% lower stiffness and 19% lower hardness promoting plastic deformation in pathological bone. At the microstructural scale, trabecular regions are known to become densified, whereas cortical bone loses its characteristic parallel-aligned osteonal pattern, which is replaced with a mosaic of lamellar and woven bone. Although we find this loss of anisotropic alignment produces a straighter crack path in mechanically-loaded PDB cases, cortical fracture toughness appears to be maintained due to increased plastic deformation. Clearly, the altered quality of the bone structure in PDB affects the mechanical integrity leading to complications such as bowing, deformities, and stable cracks called fissure fractures associated with this disease. Although the lower mineralization and loss of aligned Haversian structures do produce a lower modulus tissue, which is susceptible to deformities, our results indicate that the higher levels of plasticity may compensate for the lost microstructural features and maintain the resistance to crack growth. \u00a9 2014 American Society for Bone and Mineral Research<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jbmr.2340","type":"journal-article","created":{"date-parts":[[2014,8,12]],"date-time":"2014-08-12T02:35:37Z","timestamp":1407810937000},"page":"264-273","source":"Crossref","is-referenced-by-count":49,"title":["Modifications to Nano- and Microstructural Quality and the Effects on Mechanical Integrity in Paget's Disease of Bone"],"prefix":"10.1093","volume":"30","author":[{"given":"Elizabeth A","family":"Zimmermann","sequence":"first","affiliation":[{"name":"Materials Sciences DivisionLawrence Berkeley National LaboratoryBerkeleyCAUSA"},{"name":"Department of Osteology and BiomechanicsUniversity Medical Center Hamburg-EppendorfHamburgGermany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Till","family":"K\u00f6hne","sequence":"additional","affiliation":[{"name":"Department of Osteology and BiomechanicsUniversity Medical Center Hamburg-EppendorfHamburgGermany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hrishikesh A","family":"Bale","sequence":"additional","affiliation":[{"name":"Department of Materials Science and EngineeringUniversity of CaliforniaBerkeleyCAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Panganiban","sequence":"additional","affiliation":[{"name":"Department of Materials Science and EngineeringUniversity of CaliforniaBerkeleyCAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"Gludovatz","sequence":"additional","affiliation":[{"name":"Materials Sciences DivisionLawrence Berkeley National LaboratoryBerkeleyCAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joszef","family":"Zustin","sequence":"additional","affiliation":[{"name":"Institute of PathologyUniversity Medical Center Hamburg-EppendorfHamburgGermany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Hahn","sequence":"additional","affiliation":[{"name":"Department of Osteology and BiomechanicsUniversity Medical Center Hamburg-EppendorfHamburgGermany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Amling","sequence":"additional","affiliation":[{"name":"Department of Osteology and BiomechanicsUniversity Medical Center Hamburg-EppendorfHamburgGermany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert O","family":"Ritchie","sequence":"additional","affiliation":[{"name":"Department of Materials Science and EngineeringUniversity of CaliforniaBerkeleyCAUSA"},{"name":"Materials Sciences DivisionLawrence Berkeley National LaboratoryBerkeleyCAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f6rn","family":"Busse","sequence":"additional","affiliation":[{"name":"Materials Sciences DivisionLawrence Berkeley National LaboratoryBerkeleyCAUSA"},{"name":"Department of Osteology and BiomechanicsUniversity Medical Center Hamburg-EppendorfHamburgGermany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,8,12]]},"reference":[{"key":"2024020319193765100_jbmr2340-bib-0001","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1177\/095952877706000105","article-title":"On a form of chronic inflammation of bones (Osteitis Deformans)","volume":"60","author":"Paget","year":"1877","journal-title":"Med Chir Trans."},{"issue":"5","key":"2024020319193765100_jbmr2340-bib-0002","doi-asserted-by":"crossref","first-page":"11S","DOI":"10.1016\/S8756-3282(99)00027-7","article-title":"Paget's disease of bone: a review of 889 patients","volume":"24","author":"Davie","year":"1999","journal-title":"Bone."},{"issue":"1","key":"2024020319193765100_jbmr2340-bib-0003","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1359\/jbmr.080907","article-title":"Paget's disease of bone: histologic analysis of 754 patients","volume":"24","author":"Seitz","year":"2009","journal-title":"J Bone Miner Res."},{"issue":"2","key":"2024020319193765100_jbmr2340-bib-0004","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.bone.2013.04.024","article-title":"Epidemiology of Paget's disease of bone: a systematic review and meta-analysis of secular changes","volume":"55","author":"Corral-Gudino","year":"2013","journal-title":"Bone."},{"issue":"S2","key":"2024020319193765100_jbmr2340-bib-0005","doi-asserted-by":"crossref","first-page":"P14","DOI":"10.1359\/jbmr.06s203","article-title":"Paget's disease of bone in Italy","volume":"21","author":"Gennari","year":"2006","journal-title":"J Bone Miner Res."},{"issue":"5","key":"2024020319193765100_jbmr2340-bib-0006","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1007\/s00586-011-2133-7","article-title":"Paget disease of the spine: an evaluation of 101 patients with a histomorphometric analysis of 29 cases","volume":"21","author":"Pestka","year":"2012","journal-title":"Eur Spine J."},{"issue":"4\u20135","key":"2024020319193765100_jbmr2340-bib-0007","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/0221-8747(81)90039-4","article-title":"Paget's disease of bone: the anatomical distribution","volume":"3","author":"Guyer","year":"1981","journal-title":"Metab Bone Dis Relat Res."},{"issue":"4","key":"2024020319193765100_jbmr2340-bib-0008","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1359\/jbmr.1997.12.4.691","article-title":"Clinical vignette: natural history of untreated Paget's disease of the tibia","volume":"12","author":"Siris","year":"1997","journal-title":"J Bone Miner Res."},{"issue":"7","key":"2024020319193765100_jbmr2340-bib-0009","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1056\/NEJMcp1204713","article-title":"Paget's disease of bone","volume":"368","author":"Ralston","year":"2013","journal-title":"N Engl J Med."},{"issue":"8","key":"2024020319193765100_jbmr2340-bib-0010","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1359\/jbmr.2001.16.8.1379","article-title":"A clinical approach to diagnosis and management of Paget's disease of bone","volume":"16","author":"Lyles","year":"2001","journal-title":"J Bone Miner Res."},{"issue":"8","key":"2024020319193765100_jbmr2340-bib-0011","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1056\/NEJM199702203360807","article-title":"The management of Paget's disease of bone","volume":"336","author":"Delmas","year":"1997","journal-title":"N Engl J Med."},{"issue":"3","key":"2024020319193765100_jbmr2340-bib-0012","first-page":"163","article-title":"Paget's disease of bone: review with emphasis on radiologic features, part I","volume":"24","author":"Mirra","year":"1995","journal-title":"Skeletal Radiol."},{"issue":"S2","key":"2024020319193765100_jbmr2340-bib-0013","doi-asserted-by":"crossref","first-page":"P22","DOI":"10.1359\/jbmr.06s204","article-title":"Biochemical assessment of Paget's disease of bone","volume":"21","author":"Shankar","year":"2006","journal-title":"J Bone Miner Res."},{"key":"2024020319193765100_jbmr2340-bib-0014","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.bone.2013.10.024","article-title":"Bisphosphonate-osteoclasts: changes in osteoclast morphology and function induced by antiresorptive nitrogen-containing bisphosphonate treatment in osteoporosis patients","volume":"59","author":"Jobke","year":"2014","journal-title":"Bone."},{"issue":"10","key":"2024020319193765100_jbmr2340-bib-0015","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1002\/art.1780231005","article-title":"Bone histomorphometry in Paget's disease. Quantitative and dynamic analysis of pagetic and nonpagetic bone tissue","volume":"23","author":"Meunier","year":"1980","journal-title":"Arthritis Rheum."},{"issue":"10","key":"2024020319193765100_jbmr2340-bib-0016","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1002\/art.1780231006","article-title":"Bone tissue in Paget's disease of bone ultrastructure and immunocytology","volume":"23","author":"Rebel","year":"1980","journal-title":"Arthritis Rheum."},{"key":"2024020319193765100_jbmr2340-bib-0017","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/srep00435","article-title":"Correlative light and scanning X-ray scattering microscopy of healthy and pathologic human bone sections","volume":"2","author":"Giannini","year":"2012","journal-title":"Sci Rep."},{"issue":"35","key":"2024020319193765100_jbmr2340-bib-0018","doi-asserted-by":"crossref","first-page":"14416","DOI":"10.1073\/pnas.1107966108","article-title":"Age-related changes in the plasticity,toughness of human cortical bone at multiple length scales","volume":"108","author":"Zimmermann","year":"2011","journal-title":"Proc Natl Acad Sci U S.A."},{"issue":"193","key":"2024020319193765100_jbmr2340-bib-0019","doi-asserted-by":"crossref","first-page":"193ra88","DOI":"10.1126\/scitranslmed.3006286","article-title":"Vitamin D deficiency induces early signs of aging in human bone, increasing the risk of fracture","volume":"5","author":"Busse","year":"2013","journal-title":"Sci Transl Med."},{"issue":"34","key":"2024020319193765100_jbmr2340-bib-0020","doi-asserted-by":"crossref","first-page":"8892","DOI":"10.1016\/j.biomaterials.2011.08.013","article-title":"Characterization of the effects of x-ray irradiation on the hierarchical structure and mechanical properties of human cortical bone","volume":"32","author":"Barth","year":"2011","journal-title":"Biomaterials."},{"issue":"6","key":"2024020319193765100_jbmr2340-bib-0021","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1002\/jbmr.2172","article-title":"How tough is brittle bone? Investigating osteogenesis imperfecta in mouse bone","volume":"29","author":"Carriero","year":"2014","journal-title":"J Bone Miner Res."},{"issue":"1","key":"2024020319193765100_jbmr2340-bib-0022","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1146\/annurev-matsci-070909-104427","article-title":"On the mechanistic origins of toughness in bone","volume":"40","author":"Launey","year":"2010","journal-title":"Annu Rev Mater Res."},{"issue":"11","key":"2024020319193765100_jbmr2340-bib-0023","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1359\/jbmr.2000.15.11.2123","article-title":"Fracture risk among patients with Paget's disease: a population-based cohort study","volume":"15","author":"Melton","year":"2000","journal-title":"J Bone Miner Res."},{"issue":"3","key":"2024020319193765100_jbmr2340-bib-0024","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1359\/jbmr.2002.17.3.465","article-title":"Incidence and natural history of Paget's disease of bone in England and Wales","volume":"17","author":"Van Staa","year":"2002","journal-title":"J Bone Miner Res."},{"issue":"12","key":"2024020319193765100_jbmr2340-bib-0025","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1002\/jbmr.5650111210","article-title":"Paget's disease of bone and quality of life","volume":"11","author":"Gold","year":"1996","journal-title":"J Bone Miner Res."},{"issue":"1","key":"2024020319193765100_jbmr2340-bib-0026","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1359\/jbmr.090709","article-title":"Randomized trial of intensive bisphosphonate treatment versus symptomatic management in Paget's disease of bone","volume":"25","author":"Langston","year":"2010","journal-title":"J Bone Miner Res."},{"issue":"1","key":"2024020319193765100_jbmr2340-bib-0027","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1302\/0301-620X.62B1.7351428","article-title":"Complete fractures of the femur in Paget's disease of bone","volume":"62-B","author":"Dove","year":"1980","journal-title":"J Bone Joint Surg Br."},{"issue":"2","key":"2024020319193765100_jbmr2340-bib-0028","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1385\/BMM:1:2:115","article-title":"Radiographic diagnosis and laboratory evaluation of Paget's disease of bone","volume":"1","author":"Cushing","year":"2002","journal-title":"Clin Rev Bone Miner Metab."},{"issue":"2","key":"2024020319193765100_jbmr2340-bib-0029","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1302\/0301-620X.52B2.252","article-title":"Fractures of the femur in Paget's disease of bone their etiology and treatment","volume":"52","author":"Grundy","year":"1970","journal-title":"J Bone Joint Surg Br."},{"issue":"2","key":"2024020319193765100_jbmr2340-bib-0030","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/BF00267839","article-title":"Management of fissure fractures in Paget's disease","volume":"5","author":"Redden","year":"1981","journal-title":"Int Orthop."},{"issue":"6","key":"2024020319193765100_jbmr2340-bib-0031","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s00068-008-8208-4","article-title":"The second most common bone disease: a review on Paget's disease of bone","volume":"34","author":"Seitz","year":"2008","journal-title":"Eur J Trauma Emerg Surg."},{"issue":"2","key":"2024020319193765100_jbmr2340-bib-0032","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1359\/jbmr.090728","article-title":"Bone mineralization defects and vitamin D deficiency: histomorphometric analysis of iliac crest bone biopsies and circulating 25-hydroxyvitamin D in 675 patients","volume":"25","author":"Priemel","year":"2010","journal-title":"J Bone Miner Res."},{"key":"2024020319193765100_jbmr2340-bib-0033","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.bone.2014.05.010","article-title":"Trends in trabecular architecture and bone mineral density distribution in 152 individuals aged30-90 years","volume":"66","author":"Koehne","year":"2014","journal-title":"Bone."},{"issue":"1","key":"2024020319193765100_jbmr2340-bib-0034","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/jbmr.1805","article-title":"Standardized nomenclature, symbols, and units for bone histomorphometry: a 2012 update of the report of the ASBMR Histomorphometry Nomenclature Committee","volume":"28","author":"Dempster","year":"2013","journal-title":"J Bone Miner Res."},{"key":"2024020319193765100_jbmr2340-bib-0035","first-page":"1537","article-title":"Scanning electron microscopy in bone pathology: review of methods, potential and applications","author":"Boyde","year":"1986","journal-title":"Scan Electron Microsc."},{"issue":"3","key":"2024020319193765100_jbmr2340-bib-0036","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s002239900600","article-title":"The mineralization density of iliac crest bone from children with osteogenesis imperfecta","volume":"64","author":"Boyde","year":"1999","journal-title":"Calcif Tissue Int."},{"issue":"1","key":"2024020319193765100_jbmr2340-bib-0037","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1002\/jbm.820270108","article-title":"Influence of mineral content and composition on graylevels in backscattered electron images of bone","volume":"27","author":"Skedros","year":"1993","journal-title":"J Biomed Mater Res."},{"issue":"1","key":"2024020319193765100_jbmr2340-bib-0038","first-page":"75","article-title":"A new scanning electron microscopy approach to the quantification of bone mineral distribution: backscattered electron image grey-levels correlated to calcium K alpha-line intensities","volume":"9","author":"Roschger","year":"1995","journal-title":"Scanning Microsc."},{"issue":"1","key":"2024020319193765100_jbmr2340-bib-0039","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.bone.2012.11.009","article-title":"Osteopetrosis, osteopetrorickets and hypophosphatemic rickets differentially affect dentin and enamel mineralization","volume":"53","author":"Koehne","year":"2013","journal-title":"Bone."},{"issue":"3","key":"2024020319193765100_jbmr2340-bib-0040","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.bone.2007.10.021","article-title":"Bone mineralization density distribution in health and disease","volume":"42","author":"Roschger","year":"2008","journal-title":"Bone."},{"issue":"15","key":"2024020319193765100_jbmr2340-bib-0041","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1016\/j.biomaterials.2006.11.043","article-title":"FT-IR imaging of native and tissue-engineered bone and cartilage","volume":"28","author":"Boskey","year":"2007","journal-title":"Biomaterials."},{"issue":"10","key":"2024020319193765100_jbmr2340-bib-0042","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1359\/jbmr.2001.16.10.1821","article-title":"Spectroscopic characterization of collagen cross-links in bone","volume":"16","author":"Paschalis","year":"2001","journal-title":"J Bone Miner Res."},{"issue":"4","key":"2024020319193765100_jbmr2340-bib-0043","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s00774-009-0146-7","article-title":"Mineral maturity and crystallinity index are distinct characteristics of bone mineral","volume":"28","author":"Farlay","year":"2010","journal-title":"J Bone Miner Metab."},{"key":"2024020319193765100_jbmr2340-bib-0044","doi-asserted-by":"crossref","first-page":"441","DOI":"10.22203\/eCM.v024a31","article-title":"Changes to the cell, tissue and architecture levels in cranial suture synostosis reveal a problem of timing in bone development","author":"Regelsberger","year":"2012","journal-title":"Eur Cell Mater."},{"key":"2024020319193765100_jbmr2340-bib-0045","author":"ASTM E1820-09","year":"2009"},{"issue":"2","key":"2024020319193765100_jbmr2340-bib-0046","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/BF00012619","article-title":"Slightly curved or kinked cracks","volume":"16","author":"Cotterell","year":"1980","journal-title":"Int J Fract."},{"issue":"12","key":"2024020319193765100_jbmr2340-bib-0047","doi-asserted-by":"crossref","first-page":"e28736","DOI":"10.1371\/journal.pone.0028736","article-title":"The ratio 1660\/1690 cm\u22121 measured by infrared microspectroscopy is not specific of enzymatic collagen cross-links in bone tissue","volume":"6","author":"Farlay","year":"2011","journal-title":"PloS One."},{"issue":"2","key":"2024020319193765100_jbmr2340-bib-0048","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1002\/1529-0131(199802)41:2<354::AID-ART20>3.0.CO;2-5","article-title":"Measurement of urinary excretion of nonisomerized and \u03b2-isomerized forms of type I collagen breakdown products to monitor the effects of the bisphosphonate zoledronate in Paget's disease","volume":"41","author":"Garnero","year":"1998","journal-title":"Arthritis Rheum."},{"issue":"1","key":"2024020319193765100_jbmr2340-bib-0049","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/S1047-8477(02)00578-6","article-title":"Structural differences between \u201cdark\u201d and \u201cbright\u201d isolated human osteonic lamellae","volume":"141","author":"Ascenzi","year":"2003","journal-title":"J Struct Biol."},{"issue":"6","key":"2024020319193765100_jbmr2340-bib-0050","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/0221-8747(84)90017-1","article-title":"Collagen orientation in compact bone: I. A new method for the determination of the proportion of collagen parallel to the plane of compact bone sections","volume":"5","author":"Boyde","year":"1984","journal-title":"Metab Bone Dis Relat Res."},{"issue":"8","key":"2024020319193765100_jbmr2340-bib-0051","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1002\/jbmr.73","article-title":"Microindentation for in vivo measurement of bone tissue mechanical properties in humans","volume":"25","author":"Diez-Perez","year":"2010","journal-title":"J Bone Miner Res."},{"issue":"4","key":"2024020319193765100_jbmr2340-bib-0052","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1002\/adma.200801204","article-title":"The effect of NaF in vitro on the mechanical and material properties of trabecular and cortical bone","volume":"21","author":"Thurner","year":"2009","journal-title":"Adv Mater."},{"issue":"8","key":"2024020319193765100_jbmr2340-bib-0053","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1038\/nmat2221","article-title":"The true toughness of human cortical bone measured with realistically short cracks","volume":"7","author":"Koester","year":"2008","journal-title":"Nat Mater."},{"issue":"4","key":"2024020319193765100_jbmr2340-bib-0054","first-page":"486","article-title":"The multiscale origins of fracture resistance in human bone and its biological degradation","volume":"64","author":"Zimmermann","year":"2012","journal-title":"JOM 1989."},{"issue":"1","key":"2024020319193765100_jbmr2340-bib-0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0021-9290(69)90036-0","article-title":"The mechanical consequences of variation in the mineral content of bone","volume":"2","author":"Currey","year":"1969","journal-title":"J Biomech."},{"issue":"4","key":"2024020319193765100_jbmr2340-bib-0056","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1016\/S0006-3495(00)76426-5","article-title":"Mineralized collagen fibrils: a mechanical model with a staggered arrangement of mineral particles","volume":"79","author":"Jager","year":"2000","journal-title":"Biophys J."},{"issue":"3","key":"2024020319193765100_jbmr2340-bib-0057","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1002\/jbm.a.32442","article-title":"Effects of tissue age on bone tissue material composition and nanomechanical properties in the rat cortex","volume":"92","author":"Donnelly","year":"2010","journal-title":"J Biomed Mater Res A."},{"issue":"7","key":"2024020319193765100_jbmr2340-bib-0058","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1359\/jbmr.1998.13.7.1061","article-title":"Paget's disease of bone","volume":"13","author":"Siris","year":"1998","journal-title":"J Bone Miner Res."}],"container-title":["Journal of Bone and Mineral Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbmr.2340","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbmr.2340","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/30\/2\/264\/56568857\/jbmr2340.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/30\/2\/264\/56568857\/jbmr2340.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T10:52:48Z","timestamp":1710327168000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbmr\/article\/30\/2\/264-273\/7599320"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,12]]},"references-count":58,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2014,8,12]]},"published-print":{"date-parts":[[2015,2,1]]}},"URL":"https:\/\/doi.org\/10.1002\/jbmr.2340","relation":{},"ISSN":["0884-0431","1523-4681"],"issn-type":[{"value":"0884-0431","type":"print"},{"value":"1523-4681","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2015,2,1]]},"published":{"date-parts":[[2014,8,12]]}}}