{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T23:37:32Z","timestamp":1790206652083,"version":"4.1.0"},"reference-count":63,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,3,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>\u2003<\/jats:title>\n                  <jats:p>Osteocytes secrete paracrine factors that regulate the balance between bone formation and destruction. Among these molecules, sclerostin (encoded by the gene SOST) inhibits osteoblastic bone formation and is an osteoporosis drug target. The molecular mechanisms underlying SOST expression remain largely unexplored. Here, we report that histone deacetylase 5 (HDAC5) negatively regulates sclerostin levels in osteocytes in vitro and in vivo. HDAC5 shRNA increases, whereas HDAC5 overexpression decreases SOST expression in the novel murine Ocy454 osteocytic cell line. HDAC5 knockout mice show increased levels of SOST mRNA, more sclerostin-positive osteocytes, decreased Wnt activity, low trabecular bone density, and reduced bone formation by osteoblasts. In osteocytes, HDAC5 binds and inhibits the function of MEF2C, a crucial transcription factor for SOST expression. Using chromatin immunoprecipitation, we have mapped endogenous MEF2C binding in the SOST gene to a distal intergenic enhancer 45 kB downstream from the transcription start site. HDAC5 deficiency increases SOST enhancer MEF2C chromatin association and H3K27 acetylation and decreases recruitment of corepressors NCoR and HDAC3. HDAC5 associates with and regulates the transcriptional activity of this enhancer, suggesting direct regulation of SOST gene expression by HDAC5 in osteocytes. Finally, increased sclerostin production achieved by HDAC5 shRNA is abrogated by simultaneous knockdown of MEF2C, indicating that MEF2C is a major target of HDAC5 in osteocytes. \u00a9 2014 American Society for Bone and Mineral Research.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/jbmr.2381","type":"journal-article","created":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T08:38:28Z","timestamp":1412152708000},"page":"400-411","source":"Crossref","is-referenced-by-count":154,"title":["HDAC5 Controls MEF2C-Driven Sclerostin Expression in Osteocytes"],"prefix":"10.1093","volume":"30","author":[{"given":"Marc N","family":"Wein","sequence":"first","affiliation":[{"name":"Endocrine UnitMassachusetts General HospitalBostonMAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan","family":"Spatz","sequence":"additional","affiliation":[{"name":"Center for Advanced Orthopaedic StudiesBIDMCBostonMAUSA"},{"name":"Harvard\u2013Massachusetts Institute of Technology (MIT) Division of Health Sciences and Technology (HST)Bioastronautics ProgramCambridgeMAUSA"},{"name":"Endocrine UnitMassachusetts General HospitalBostonMAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeki","family":"Nishimori","sequence":"additional","affiliation":[{"name":"Endocrine UnitMassachusetts General HospitalBostonMAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Doench","sequence":"additional","affiliation":[{"name":"Broad Institute of MIT and HarvardCambridgeMAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Root","sequence":"additional","affiliation":[{"name":"Broad Institute of MIT and HarvardCambridgeMAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Babij","sequence":"additional","affiliation":[{"name":"Amgen, Inc., Department of Metabolic DisordersThousand OaksCAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Nagano","sequence":"additional","affiliation":[{"name":"Harvard School of Dental MedicineBostonMAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Baron","sequence":"additional","affiliation":[{"name":"Harvard School of Dental MedicineBostonMAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Brooks","sequence":"additional","affiliation":[{"name":"Center for Advanced Orthopaedic StudiesBIDMCBostonMAUSA"},{"name":"Endocrine UnitMassachusetts General HospitalBostonMAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Bouxsein","sequence":"additional","affiliation":[{"name":"Center for Advanced Orthopaedic StudiesBIDMCBostonMAUSA"},{"name":"Endocrine UnitMassachusetts General HospitalBostonMAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola Divieti","family":"Pajevic","sequence":"additional","affiliation":[{"name":"Endocrine UnitMassachusetts General HospitalBostonMAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry M","family":"Kronenberg","sequence":"additional","affiliation":[{"name":"Endocrine UnitMassachusetts General HospitalBostonMAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,10,1]]},"reference":[{"issue":"2","key":"2024020319181031100_jbmr2381-bib-0001","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/jbmr.320","article-title":"The amazing osteocyte","volume":"26","author":"Bonewald","year":"2011","journal-title":"J Bone Miner Res."},{"issue":"10","key":"2024020319181031100_jbmr2381-bib-0002","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1038\/nm.2452","article-title":"Evidence for osteocyte regulation of bone homeostasis through RANKL expression","volume":"17","author":"Nakashima","year":"2011","journal-title":"Nat Med."},{"issue":"10","key":"2024020319181031100_jbmr2381-bib-0003","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1038\/nm.2448","article-title":"Matrix-embedded cells control osteoclast formation","volume":"17","author":"Xiong","year":"2011","journal-title":"Nat Med."},{"issue":"6","key":"2024020319181031100_jbmr2381-bib-0004","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1359\/jbmr.080216","article-title":"Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength","volume":"23","author":"Li","year":"2008","journal-title":"J Bone Miner Res."},{"issue":"3","key":"2024020319181031100_jbmr2381-bib-0005","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1086\/318811","article-title":"Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein","volume":"68","author":"Brunkow","year":"2001","journal-title":"Am J Hum Genet."},{"issue":"2","key":"2024020319181031100_jbmr2381-bib-0006","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1136\/jmg.39.2.91","article-title":"Identification of a 52 kb deletion downstream of the SOST gene in patients with van Buchem disease","volume":"39","author":"Balemans","year":"2002","journal-title":"J Med Genet."},{"issue":"8","key":"2024020319181031100_jbmr2381-bib-0007","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/nrg3228","article-title":"Genetics of osteoporosis from genome-wide association studies: advances and challenges","volume":"13","author":"Richards","year":"2012","journal-title":"Nat Rev Genet."},{"issue":"5","key":"2024020319181031100_jbmr2381-bib-0008","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1056\/NEJMoa1305224","article-title":"Romosozumab in postmenopausal women with low bone mineral density","volume":"370","author":"McClung","year":"2014","journal-title":"N Engl J Med."},{"issue":"2","key":"2024020319181031100_jbmr2381-bib-0009","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.bone.2005.03.018","article-title":"SOST is a target gene for PTH in bone","volume":"37","author":"Keller","year":"2005","journal-title":"Bone."},{"issue":"11","key":"2024020319181031100_jbmr2381-bib-0010","doi-asserted-by":"crossref","first-page":"4577","DOI":"10.1210\/en.2005-0239","article-title":"Chronic elevation of parathyroid hormone in mice reduces expression of sclerostin by osteocytes: a novel mechanism for hormonal control of osteoblastogenesis","volume":"146","author":"Bellido","year":"2005","journal-title":"Endocrinology."},{"issue":"12","key":"2024020319181031100_jbmr2381-bib-0011","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1359\/jbmr.070804","article-title":"Control of the SOST bone enhancer by PTH using MEF2 transcription factors","volume":"22","author":"Leupin","year":"2007","journal-title":"J Bone Miner Res."},{"issue":"10","key":"2024020319181031100_jbmr2381-bib-0012","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1359\/jbmr.090411","article-title":"Sclerostin mediates bone response to mechanical unloading through antagonizing Wnt\/beta-catenin signaling","volume":"24","author":"Lin","year":"2009","journal-title":"J Bone Miner Res."},{"issue":"1","key":"2024020319181031100_jbmr2381-bib-0013","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.bone.2011.10.025","article-title":"Sost downregulation and local Wnt signaling are required for the osteogenic response to mechanical loading","volume":"50","author":"Tu","year":"2012","journal-title":"Bone."},{"issue":"9","key":"2024020319181031100_jbmr2381-bib-0014","doi-asserted-by":"crossref","first-page":"5866","DOI":"10.1074\/jbc.M705092200","article-title":"Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost\/sclerostin","volume":"283","author":"Robling","year":"2008","journal-title":"J Biol Chem."},{"issue":"4","key":"2024020319181031100_jbmr2381-bib-0015","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1002\/jbmr.1807","article-title":"Sclerostin antibody inhibits skeletal deterioration due to reduced mechanical loading","volume":"28","author":"Spatz","year":"2012","journal-title":"J Bone Miner Res."},{"issue":"2","key":"2024020319181031100_jbmr2381-bib-0016","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1002\/jbmr.1492","article-title":"Mef2c deletion in osteocytes results in increased bone mass","volume":"27","author":"Kramer","year":"2012","journal-title":"J Bone Miner Res."},{"issue":"35","key":"2024020319181031100_jbmr2381-bib-0017","doi-asserted-by":"crossref","first-page":"14092","DOI":"10.1073\/pnas.1207188109","article-title":"Targeted deletion of Sost distal enhancer increases bone formation,bone mass","volume":"109","author":"Collette","year":"2012","journal-title":"Proc Natl Acad Sci USA."},{"issue":"5942","key":"2024020319181031100_jbmr2381-bib-0018","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1126\/science.1175371","article-title":"Lysine acetylation targets protein complexes and co-regulates major cellular functions","volume":"325","author":"Choudhary","year":"2009","journal-title":"Science."},{"issue":"37","key":"2024020319181031100_jbmr2381-bib-0019","doi-asserted-by":"crossref","first-page":"5450","DOI":"10.1038\/sj.onc.1210613","article-title":"Class IIa histone deacetylases: regulating the regulators","volume":"26","author":"Martin","year":"2007","journal-title":"Oncogene."},{"issue":"1","key":"2024020319181031100_jbmr2381-bib-0020","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/nrg2485","article-title":"The many roles of histone deacetylases in development and physiology: implications for disease and therapy","volume":"10","author":"Haberland","year":"2009","journal-title":"Nat Rev Genet."},{"issue":"13","key":"2024020319181031100_jbmr2381-bib-0021","doi-asserted-by":"crossref","first-page":"9616","DOI":"10.1074\/jbc.M109.094862","article-title":"HDAC4 represses matrix metalloproteinase-13 transcription in osteoblastic cells, and parathyroid hormone controls this repression","volume":"285","author":"Shimizu","year":"2010","journal-title":"J Biol Chem."},{"issue":"31","key":"2024020319181031100_jbmr2381-bib-0022","doi-asserted-by":"crossref","first-page":"21340","DOI":"10.1074\/jbc.M114.550699","article-title":"Parathyroid hormone regulates histone deacetylase (HDAC) 4 through protein kinase A-mediated phosphorylation and dephosphorylation in osteoblastic cells","volume":"289","author":"Shimizu","year":"2014","journal-title":"J Biol Chem."},{"issue":"6","key":"2024020319181031100_jbmr2381-bib-0023","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1083\/jcb.201403138","article-title":"HDAC4 integrates PTH and sympathetic signaling in osteoblasts","volume":"205","author":"Obri","year":"2014","journal-title":"J Cell Biol."},{"issue":"36","key":"2024020319181031100_jbmr2381-bib-0024","doi-asserted-by":"crossref","first-page":"24995","DOI":"10.1074\/jbc.M114.564997","article-title":"Class I and IIa histone deacetylases have opposite effects on sclerostin gene regulation","volume":"289","author":"Baertschi","year":"2014","journal-title":"J Biol Chem."},{"issue":"6","key":"2024020319181031100_jbmr2381-bib-0025","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/j.bone.2011.08.016","article-title":"Sclerostin expression is induced by BMPs in human Saos-2 osteosarcoma cells but not via direct effects on the sclerostin gene promoter or ECR5 element","volume":"49","author":"Yu","year":"2011","journal-title":"Bone."},{"issue":"9","key":"2024020319181031100_jbmr2381-bib-0026","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/nmeth924","article-title":"Genome-scale loss-of-function screening with a lentiviral RNAi library","volume":"3","author":"Root","year":"2006","journal-title":"Nat Methods."},{"issue":"6","key":"2024020319181031100_jbmr2381-bib-0027","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1016\/j.cell.2006.01.040","article-title":"A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen","volume":"124","author":"Moffat","year":"2006","journal-title":"Cell."},{"key":"2024020319181031100_jbmr2381-bib-0028","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/978-1-59745-104-8_11","article-title":"Lentivirus delivery of shRNA constructs into osteoblasts","volume":"455","author":"Wein","year":"2008","journal-title":"Methods Mol Biol."},{"issue":"9","key":"2024020319181031100_jbmr2381-bib-0029","doi-asserted-by":"crossref","first-page":"3492","DOI":"10.1172\/JCI46406","article-title":"Gsalpha enhances commitment of mesenchymal progenitors to the osteoblast lineage but restrains osteoblast differentiation in mice","volume":"121","author":"Wu","year":"2011","journal-title":"J Clin Invest."},{"issue":"6","key":"2024020319181031100_jbmr2381-bib-0030","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1182\/blood-2012-06-437160","article-title":"Myelopoiesis is regulated by osteocytes through Gsalpha-dependent signaling","volume":"121","author":"Fulzele","year":"2013","journal-title":"Blood."},{"issue":"10","key":"2024020319181031100_jbmr2381-bib-0031","doi-asserted-by":"crossref","first-page":"e25900","DOI":"10.1371\/journal.pone.0025900","article-title":"Sclerostin stimulates osteocyte support of osteoclast activity by a RANKL-dependent pathway","volume":"6","author":"Wijenayaka","year":"2011","journal-title":"PLoS One."},{"issue":"19","key":"2024020319181031100_jbmr2381-bib-0032","doi-asserted-by":"crossref","first-page":"8374","DOI":"10.1128\/MCB.24.19.8374-8385.2004","article-title":"Protein kinases C and D mediate agonist-dependent cardiac hypertrophy through nuclear export of histone deacetylase 5","volume":"24","author":"Vega","year":"2004","journal-title":"Mol Cell Biol."},{"issue":"5","key":"2024020319181031100_jbmr2381-bib-0033","doi-asserted-by":"crossref","first-page":"401","DOI":"10.3109\/03008207.2010.546536","article-title":"Keratocan is expressed by osteoblasts and can modulate osteogenic differentiation","volume":"52","author":"Igwe","year":"2011","journal-title":"Connect Tissue Res."},{"issue":"4","key":"2024020319181031100_jbmr2381-bib-0034","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.bone.2009.06.010","article-title":"Identification of differentially expressed genes between osteoblasts and osteocytes","volume":"45","author":"Paic","year":"2009","journal-title":"Bone."},{"issue":"19","key":"2024020319181031100_jbmr2381-bib-0035","doi-asserted-by":"crossref","first-page":"8467","DOI":"10.1128\/MCB.24.19.8467-8476.2004","article-title":"Histone deacetylases 5 and 9 govern responsiveness of the heart to a subset of stress signals and play redundant roles in heart development","volume":"24","author":"Chang","year":"2004","journal-title":"Mol Cell Biol."},{"issue":"3","key":"2024020319181031100_jbmr2381-bib-0036","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.neuron.2007.09.032","article-title":"Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli","volume":"56","author":"Renthal","year":"2007","journal-title":"Neuron."},{"issue":"3","key":"2024020319181031100_jbmr2381-bib-0037","doi-asserted-by":"crossref","first-page":"153","DOI":"10.2220\/biomedres.34.153","article-title":"Sclerostin is differently immunolocalized in metaphyseal trabecules and cortical bones of mouse tibiae","volume":"34","author":"Hasegawa","year":"2013","journal-title":"Biomed Res."},{"issue":"2","key":"2024020319181031100_jbmr2381-bib-0038","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nm.3074","article-title":"WNT signaling in bone homeostasis and disease: from human mutations to treatments","volume":"19","author":"Baron","year":"2013","journal-title":"Nat Med."},{"issue":"2","key":"2024020319181031100_jbmr2381-bib-0039","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1359\/jbmr.081235","article-title":"Where Wnts went: the exploding field of Lrp5 and Lrp6 signaling in bone","volume":"24","author":"Williams","year":"2009","journal-title":"J Bone Miner Res."},{"issue":"6112","key":"2024020319181031100_jbmr2381-bib-0040","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1126\/science.1228734","article-title":"Kinetic responses of beta-catenin specify the sites of Wnt control","volume":"338","author":"Hernandez","year":"2012","journal-title":"Science."},{"issue":"6","key":"2024020319181031100_jbmr2381-bib-0041","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/S0092-8674(02)00685-2","article-title":"Control of beta-catenin phosphorylation\/degradation by a dual-kinase mechanism","volume":"108","author":"Liu","year":"2002","journal-title":"Cell."},{"issue":"3","key":"2024020319181031100_jbmr2381-bib-0042","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.stem.2012.05.023","article-title":"Developmental stage and time dictate the fate of Wnt\/beta-catenin-responsive stem cells in the mammary gland","volume":"11","author":"van Amerongen","year":"2012","journal-title":"Cell Stem Cell."},{"issue":"10","key":"2024020319181031100_jbmr2381-bib-0043","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1242\/dev.126.10.2045","article-title":"Transcriptional activity of MEF2 during mouse embryogenesis monitored with a MEF2-dependent transgene","volume":"126","author":"Naya","year":"1999","journal-title":"Development."},{"issue":"21","key":"2024020319181031100_jbmr2381-bib-0044","doi-asserted-by":"crossref","first-page":"5751","DOI":"10.1128\/MCB.00415-09","article-title":"Parathyroid hormone-related peptide represses chondrocyte hypertrophy through a protein phosphatase 2A\/histone deacetylase 4\/MEF2 pathway","volume":"29","author":"Kozhemyakina","year":"2009","journal-title":"Mol Cell Biol."},{"issue":"7","key":"2024020319181031100_jbmr2381-bib-0045","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1101\/gr.3437105","article-title":"Genomic deletion of a long-range bone enhancer misregulates sclerostin in Van Buchem disease","volume":"15","author":"Loots","year":"2005","journal-title":"Genome Res."},{"issue":"1","key":"2024020319181031100_jbmr2381-bib-0046","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/nrg2905","article-title":"Charting histone modifications and the functional organization of mammalian genomes","volume":"12","author":"Zhou","year":"2010","journal-title":"Nat Rev Genet."},{"issue":"7231","key":"2024020319181031100_jbmr2381-bib-0047","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1038\/nature07730","article-title":"ChIP-seq accurately predicts tissue-specific activity of enhancers","volume":"457","author":"Visel","year":"2009","journal-title":"Nature."},{"issue":"44","key":"2024020319181031100_jbmr2381-bib-0048","doi-asserted-by":"crossref","first-page":"17335","DOI":"10.1073\/pnas.0706487104","article-title":"Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases","volume":"104","author":"Lahm","year":"2007","journal-title":"Proc Natl Acad Sci USA."},{"issue":"1","key":"2024020319181031100_jbmr2381-bib-0049","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S1097-2765(01)00429-4","article-title":"Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT\/N-CoR","volume":"9","author":"Fischle","year":"2002","journal-title":"Mol Cell."},{"key":"2024020319181031100_jbmr2381-bib-0050","first-page":"004317","article-title":"Nuclear import of histone deacetylase 5 by requisite nuclear localization signal phosphorylation","author":"Greco","year":"2011","journal-title":"Mol Cell Proteomics."},{"issue":"5","key":"2024020319181031100_jbmr2381-bib-0051","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/nchembio.1223","article-title":"Selective class IIa histone deacetylase inhibition via a nonchelating zinc-binding group","volume":"9","author":"Lobera","year":"2013","journal-title":"Nat Chem Biol."},{"issue":"24","key":"2024020319181031100_jbmr2381-bib-0052","doi-asserted-by":"crossref","first-page":"16502","DOI":"10.1074\/jbc.M512494200","article-title":"Bone morphogenetic protein-2 stimulates Runx2 acetylation","volume":"281","author":"Jeon","year":"2006","journal-title":"J Biol Chem."},{"issue":"14","key":"2024020319181031100_jbmr2381-bib-0053","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1038\/sj.emboj.7600729","article-title":"Repression of Runx2 function by TGF-beta through recruitment of class II histone deacetylases by Smad3","volume":"24","author":"Kang","year":"2005","journal-title":"Embo J."},{"issue":"12","key":"2024020319181031100_jbmr2381-bib-0054","doi-asserted-by":"crossref","first-page":"3666","DOI":"10.1172\/JCI39832","article-title":"A novel microRNA targeting HDAC5 regulates osteoblast differentiation in mice and contributes to primary osteoporosis in humans","volume":"119","author":"Li","year":"2009","journal-title":"J Clin Invest."},{"issue":"2","key":"2024020319181031100_jbmr2381-bib-0055","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1042\/BJ20110062","article-title":"RANKL induces NFATc1 acetylation,stability via histone acetyltransferases during osteoclast differentiation","volume":"436","author":"Kim","year":"2011","journal-title":"Biochem J."},{"issue":"5","key":"2024020319181031100_jbmr2381-bib-0056","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1002\/jbmr.304","article-title":"PTH receptor signaling in osteocytes governs periosteal bone formation and intracortical remodeling","volume":"26","author":"Rhee","year":"2011","journal-title":"J Bone Miner Res."},{"issue":"4","key":"2024020319181031100_jbmr2381-bib-0057","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.coph.2010.04.004","article-title":"Regulatory signal transduction pathways for class IIa histone deacetylases","volume":"10","author":"Parra","year":"2010","journal-title":"Curr Opin Pharmacol."},{"issue":"13","key":"2024020319181031100_jbmr2381-bib-0058","doi-asserted-by":"crossref","first-page":"9035","DOI":"10.1074\/jbc.M112.405456","article-title":"Estrogen receptor alpha mediates proliferation of osteoblastic cells stimulated by estrogen and mechanical strain, but their acute down-regulation of the Wnt antagonist Sost is mediated by estrogen receptor beta","volume":"288","author":"Galea","year":"2013","journal-title":"J Biol Chem."},{"key":"2024020319181031100_jbmr2381-bib-0059","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/978-1-61779-415-5_6","article-title":"Studying osteocyte function using the cell lines MLO-Y4 and MLO-A5","volume":"816","author":"Rosser","year":"2012","journal-title":"Methods Mol Biol."},{"issue":"11","key":"2024020319181031100_jbmr2381-bib-0060","doi-asserted-by":"crossref","first-page":"2634","DOI":"10.1002\/jbmr.465","article-title":"Cell line IDG-SW3 replicates osteoblast-to-late-osteocyte differentiation in vitro and accelerates bone formation in vivo","volume":"26","author":"Woo","year":"2011","journal-title":"J Bone Miner Res."},{"issue":"11","key":"2024020319181031100_jbmr2381-bib-0061","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1038\/ng.446","article-title":"Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies","volume":"41","author":"Rivadeneira","year":"2009","journal-title":"Nat Genet."},{"issue":"5","key":"2024020319181031100_jbmr2381-bib-0062","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/ng.2249","article-title":"Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture","volume":"44","author":"Estrada","year":"2012","journal-title":"Nat Genet."},{"issue":"1","key":"2024020319181031100_jbmr2381-bib-0063","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/ng.284","article-title":"New sequence variants associated with bone mineral density","volume":"41","author":"Styrkarsdottir","year":"2009","journal-title":"Nat Genet."}],"container-title":["Journal of Bone and Mineral Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbmr.2381","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/30\/3\/400\/56568234\/jbmr2381.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/30\/3\/400\/56568234\/jbmr2381.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T14:53:06Z","timestamp":1710341586000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbmr\/article\/30\/3\/400-411\/7599249"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,1]]},"references-count":63,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2014,10,1]]},"published-print":{"date-parts":[[2015,3,1]]}},"URL":"https:\/\/doi.org\/10.1002\/jbmr.2381","relation":{},"ISSN":["0884-0431","1523-4681"],"issn-type":[{"value":"0884-0431","type":"print"},{"value":"1523-4681","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2015,3,1]]},"published":{"date-parts":[[2014,10,1]]}}}