{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T18:54:43Z","timestamp":1757703283411},"reference-count":66,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2010,9,2]],"date-time":"2010-09-02T00:00:00Z","timestamp":1283385600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The application of tetracycline-based iliac bone histomorphometry to the study of the pathogenesis of osteoporosis has given conflicting results. Accordingly, we performed this procedure in 78 postmenopausal white women with one or more vertebral fractures identified according to rigorous criteria that excluded other causes of vertebral deformity and 66 healthy postmenopausal white women recruited from the same geographic region; the groups did not differ in age or weight. In each subject, measurements were made separately on the cancellous (Cn), endocortical (Ec), and intracortical (Ct) subdivisions of the endosteal envelope. In the fracture patients, osteoblast surface was reduced substantially on each subdivision, most markedly on the Cn surface, where about 25% of the deficit was in cuboidal (type II) osteoblasts, suggesting impaired recruitment; the remaining 75% of the deficit was in intermediate (type III) cells, suggesting earlier transition from type III to type IV (flat) cells. On the Ec and Ct surfaces, the deficit was exclusively in type III cells. Mean bone formation rate was reduced by about 18% on the Cn but not on the Ec or Ct surfaces. The deficit was more significant in subjects matched for Cn BV\/TV when adjusted for the inverse regression on osteocyte density and after logarithmic transformation. The difference in bone formation rate resulted from a corresponding reduction in wall thickness without a change in activation frequency. The frequency distribution of bone formation rate was more skewed to the left in the fracture patients than in the controls. Osteoclast surface was significantly lower on each subdivision. The variation in osteoblast surface, bone formation rate, and osteoclast surface was significantly greater in the fracture patients than in the controls, with more abnormally low and abnormally high values. The data suggest the following conclusions: (1) The histologic heterogeneity of postmenopausal osteoporosis is reaffirmed; (2) the different subdivisions of the endosteal envelope, although in continuity, behave differently in health and disease; (3) a combination of defective osteoblast recruitment and premature osteoblast apoptosis would account for the deficit in type II and III cells and the reductions in wall thickness and bone formation rate on the Cn surface and the previously reported osteocyte deficiency in Cn bone; (4) premature disaggregation of multinuclear to mononuclear resorbing cells could account for the osteoclast deficit; and (5) some patients with vertebral fracture have one or another disorder of bone remodeling that at present cannot be identified by noninvasive means. \u00a9 2011 American Society for Bone and Mineral Research.<\/jats:p>","DOI":"10.1002\/jbmr.239","type":"journal-article","created":{"date-parts":[[2010,9,3]],"date-time":"2010-09-03T19:56:32Z","timestamp":1283543792000},"page":"475-485","source":"Crossref","is-referenced-by-count":16,"title":["Abnormal bone remodeling in patients with spontaneous painful vertebral fracture"],"prefix":"10.1093","volume":"26","author":[{"given":"Michael","family":"Parfitt","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Center for Osteoporosis and Metabolic Bone Disease, University of Arkansas for Medical Sciences, Little Rock, AR, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shijing","family":"Qiu","sequence":"additional","affiliation":[{"name":"Bone and Mineral Research Laboratory, Henry Ford Hospital, Detroit, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saroj","family":"Palnitkar","sequence":"additional","affiliation":[{"name":"Bone and Mineral Research Laboratory, Henry Ford Hospital, Detroit, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D Sudhaker","family":"Rao","sequence":"additional","affiliation":[{"name":"Bone and Mineral Research Laboratory, Henry Ford Hospital, Detroit, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2010,9,2]]},"reference":[{"key":"2024020318054603400_bib1","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1359\/jbmr.1997.12.4.498","article-title":"Effects of ethnicity and age or menopause on the remodeling and turnover of iliac bone: implications for mechanisms of bone loss","volume":"12","author":"Han","year":"1997","journal-title":"J Bone Miner Res."},{"key":"2024020318054603400_bib2","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1097\/00041552-200307000-00007","article-title":"Renal bone disease: a new conceptual framework for the interpretation of bone histomorphometry","volume":"12","author":"Parfitt","year":"2003","journal-title":"Curr Opin Nephrol Hypertens."},{"key":"2024020318054603400_bib3","first-page":"3","volume-title":"Mineral Metabolism Research in Italy","author":"Parfitt","year":"1984"},{"key":"2024020318054603400_bib4","first-page":"293","volume-title":"Osteoporosis: Recent Advances in Pathogenesis and Treatment","author":"Meunier","year":"1981"},{"key":"2024020318054603400_bib5","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/0002-9343(82)90810-5","article-title":"Postmenopausal osteoporosis: a heterogenous disorder as assessed by histomorphometric analysis of iliac crest bone from untreated patients","volume":"72","author":"Whyte","year":"1982","journal-title":"Am J Med."},{"key":"2024020318054603400_bib6","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/B978-0-7236-7046-9.50017-5","volume-title":"Nutrition in the Middle and Later Years","author":"Weinstein","year":"1983"},{"key":"2024020318054603400_bib7","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/B978-012470862-4\/50040-4","volume-title":"Osteoporosis","author":"Recker","year":"2001","edition":"2nd Ed"},{"key":"2024020318054603400_bib8","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1359\/jbmr.1999.14.7.1217","article-title":"Hormone replacement therapy prevents osteoclastic hyperactivity: a histomorphometric study in early postmenopausal women","volume":"14","author":"Eriksen","year":"1999","journal-title":"J Bone Miner Res."},{"key":"2024020318054603400_bib9","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1172\/JCI111096","article-title":"Relationship between surface, volume and thickness of iliac trabecular bone in aging and in osteoporosis: Implications for the microanatomic and cellular mechanism of bone loss","volume":"72","author":"Parfitt","year":"1983","journal-title":"J Clin Invest."},{"key":"2024020318054603400_bib10","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1002\/jbmr.5650061210","article-title":"A new method for measuring cancellous bone erosion depth: Application to the cellular mechanisms of bone loss in postmenopausal osteoporosis","volume":"6","author":"Cohen-Solal","year":"1991","journal-title":"J Bone Miner Res."},{"key":"2024020318054603400_bib11","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1002\/jbmr.5650100319","article-title":"Relations between histologic indices of bone formation: implications for the pathogenesis of spinal osteoporosis","volume":"10","author":"Parfitt","year":"1995","journal-title":"J Bone Miner Res."},{"key":"2024020318054603400_bib12","first-page":"217","article-title":"The Eleventh rib biopsy in the study of metabolic bone disease, Henry Ford Hosp","volume":"11","author":"Sedlin","year":"1963","journal-title":"Med Bull."},{"key":"2024020318054603400_bib13","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1097\/00003086-196611000-00011","article-title":"Bone and cell dynamics in the osteoporoses: a review of measurements by tetracycline bone labeling","volume":"49","author":"Villanueva","year":"1966","journal-title":"Clin Orthop."},{"key":"2024020318054603400_bib14","first-page":"598","article-title":"Cortical bone dynamics measured by means of tetracycline labeling in 21 cases of osteoporosis. 1966","volume":"68","author":"Villanueva","journal-title":"J Lab Clin Med."},{"key":"2024020318054603400_bib15","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S8756-3282(97)00019-7","article-title":"Defining osteopenia and osteoporoses: another view (with insights from a new paradigm)","volume":"20","author":"Frost","year":"1997","journal-title":"Bone."},{"key":"2024020318054603400_bib16","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1002\/jbmr.5650090802","article-title":"Perspective: The diagnosis of osteoporosis","volume":"9","author":"Kanis","year":"1994","journal-title":"J Bone Miner. Res."},{"key":"2024020318054603400_bib17","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1359\/jbmr.2003.18.9.1657","article-title":"Reduced iliac cancellous osteocyte density in patients with osteoporotic vertebral fracture","volume":"18","author":"Qiu","year":"2003","journal-title":"J Bone Miner Res."},{"key":"2024020318054603400_bib18","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/BF01625446","article-title":"A randomized trial of sodium fluoride as a treatment for postmenopausal osteoporosis","volume":"1","author":"Kleerekoper","year":"1991","journal-title":"Osteoporos Int."},{"key":"2024020318054603400_bib19","first-page":"103","volume-title":"Osteoporosis Aalborg Stifisbogtrykkeri","author":"Kleerekoper","year":"1984"},{"key":"2024020318054603400_bib20","first-page":"775","volume-title":"The Spine","author":"Parfitt","year":"1982","edition":"2nd ed"},{"key":"2024020318054603400_bib21","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1002\/jbmr.5650090817","article-title":"Reference data for bone mass, calciotropic hormones, and biochemical markers of bone remodeling in older (55\u201375) postmenopausal white and black women","volume":"9","author":"Kleerekoper","year":"1994","journal-title":"J Bone Miner Res."},{"key":"2024020318054603400_bib22","first-page":"3","volume-title":"Bone Histomorphometry: Techniques and Interpretation","author":"Rao","year":"1983"},{"key":"2024020318054603400_bib23","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/8756-3282(85)90003-1","article-title":"Metabolic bone disease with and without osteomalacia after intestinal bypass surgery: A bone histomorphometric study","volume":"6","author":"Parfitt","year":"1985","journal-title":"Bone."},{"key":"2024020318054603400_bib24","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1007\/BF02555869","article-title":"The difference in label length between demethylchlortetracycline and oxytetracycline: Implications for the interpretation of bone histomorphometry","volume":"48","author":"Parfitt","year":"1991","journal-title":"Calc Tiss Int."},{"key":"2024020318054603400_bib25","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1002\/jbmr.5650020617","article-title":"Bone histomorphometry nomenclature, symbols and units. Report of the ASBMR histomorphometry nomenclature committee","volume":"2","author":"Parfitt","year":"1987","journal-title":"J Bone Miner Res."},{"key":"2024020318054603400_bib26","first-page":"351","volume-title":"Bone: A Treatise, Vol. 1, The Osteoblast and Osteocyte","author":"Parfitt","year":"1990"},{"key":"2024020318054603400_bib27","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1002\/jbmr.5650051010","article-title":"Frequency distributions of tetracycline based measurements: Implications for the interpretation of bone formation indices in the absence of double labeled surfaces","volume":"5","author":"Foldes","year":"1990","journal-title":"J Bone Miner Res."},{"key":"2024020318054603400_bib28","first-page":"191","volume-title":"Handbook of Bone Morphometry","author":"Villanueva","year":"1983"},{"key":"2024020318054603400_bib29","doi-asserted-by":"crossref","first-page":"83","DOI":"10.3109\/10520298609110713","article-title":"A new method for identification of cement lines in undecalcified, plastic embedded sections of bone","volume":"61","author":"Villanueva","year":"1986","journal-title":"Stain Technol."},{"key":"2024020318054603400_bib30","first-page":"209","volume-title":"Clinical Disorders of Bone and Mineral Metabolism","author":"Qiu","year":"1983"},{"key":"2024020318054603400_bib31","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/0169-6009(90)90061-J","article-title":"A comparison of iliac bone histomorphometric data in post-menopausal osteoporotic and normal subjects","volume":"11","author":"Kimmel","year":"1990","journal-title":"Bone Miner."},{"key":"2024020318054603400_bib32","first-page":"7","volume-title":"Clinical Disorders of Bone and Mineral Metabolism","author":"Parfitt","year":"1989"},{"key":"2024020318054603400_bib33","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1359\/jbmr.060801","article-title":"Independent contributions of cancellous and cortical bone deficits to vertebral fracture risk in postmenopausal women","volume":"21","author":"Qiu","year":"2006","journal-title":"J Bone Min Res."},{"key":"2024020318054603400_bib34","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1002\/jbmr.5650020510","article-title":"Procollagen type I carboxyterminal extension peptide in serum as a marker of collagen biosynthesis in bone. Correlation with iliac bone formation rates and comparison with total alkaline phosphatase","volume":"2","author":"Parfitt","year":"1987","journal-title":"J Bone Miner Res."},{"key":"2024020318054603400_bib35","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1210\/jcem-67-4-741","article-title":"Bone formation fate in older normal women: concurrent assessment with bone histomorphometry, calcium kinetics, and biochemical markers","volume":"67","author":"Eastell","year":"1988","journal-title":"J Clin Endocrinol Metab."},{"key":"2024020318054603400_bib36","volume-title":"Practical Statistics for Medical Research","author":"Altman","year":"1991"},{"key":"2024020318054603400_bib37","volume-title":"Biometry: The Principles and Practices of Statistics in Biological Research","author":"Sokal","year":"1981","edition":"2nd ed"},{"key":"2024020318054603400_bib38","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S8756-3282(02)00907-9","article-title":"Relationship between osteocyte density and bone formation rate in human cancellous bone","volume":"31","author":"Qui","year":"2002","journal-title":"Bone."},{"key":"2024020318054603400_bib39","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1002\/jbmr.5650060714","article-title":"Structural and geometric changes in iliac bone: Relationship to normal aging and osteoporosis","volume":"6","author":"Foldes","year":"1991","journal-title":"J Bone Miner Res."},{"key":"2024020318054603400_bib40","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1359\/jbmr.1997.12.11.1864","article-title":"Effects of ethnicity and age or menopause on osteoblast function, bone mineralization and osteoid accumulation in iliac bone","volume":"12","author":"Parfitt","year":"1997","journal-title":"J Bone Min Res."},{"key":"2024020318054603400_bib41","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/BF01880415","article-title":"Trabecular and endocortical bone remodeling in postmenopausal osteoporosis: comparison with normal postmenopausal women","volume":"1","author":"Arlot","year":"1990","journal-title":"Osteoporosis Int."},{"key":"2024020318054603400_bib42","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1007\/s00198-003-1434-z","article-title":"Effects of raloxifene, hormone replacement therapy, and placebo on bone turnover in postmenopausal women","volume":"14","author":"Weinstein","year":"2003","journal-title":"Osteoporos Int."},{"key":"2024020318054603400_bib43","doi-asserted-by":"crossref","first-page":"3331","DOI":"10.1210\/jc.2004-2042","article-title":"Low bone formation in premenopausal women with idiopathic osteoporosis","volume":"90","author":"Donovan","year":"2005","journal-title":"J Clin Endocrinol Metab."},{"key":"2024020318054603400_bib44","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S8756-3282(02)00814-1","article-title":"The bone formation defect in idiopathic juvenile osteoporosis is surface-specific","volume":"31","author":"Rauch","year":"2002","journal-title":"Bone."},{"key":"2024020318054603400_bib45","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1002\/jbmr.5650080408","article-title":"Bone formation periods studied with triple tetracycline labels in women with postmenopausal osteoporosis","volume":"8","author":"Ott","year":"1993","journal-title":"J. Bone Miner Res."},{"key":"2024020318054603400_bib46","first-page":"377","volume-title":"Vitamin D, Biochemical, Chemical and Clinical Aspects Related to Calcium Metabolism","author":"Hattner"},{"key":"2024020318054603400_bib47","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/BF02060305","article-title":"Secretory territories and rate of matrix production of osteoblasts","volume":"14","author":"Jones","year":"1974","journal-title":"Calcif Tissue Res."},{"key":"2024020318054603400_bib48","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1210\/edrv-7-4-379","article-title":"Normal and pathological remodeling of human trabecular bone three dimensional reconstruction of the remodeling sequence, in normals and in metabolic bone disease","volume":"7","author":"Eriksen","year":"1986","journal-title":"Endocr Rev."},{"key":"2024020318054603400_bib49","first-page":"525","article-title":"Cellular and molecular alterations of osteoblasts in human disorders of bone formation","volume":"14","author":"Marie","year":"1999","journal-title":"Histol Histopathol."},{"key":"2024020318054603400_bib50","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/8756-3282(93)90182-A","article-title":"Osteoblast density and the evolution of BMUs in vertebral osteoporosis","volume":"14","author":"Brown","year":"1993","journal-title":"Bone."},{"key":"2024020318054603400_bib51","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1359\/jbmr.070518","article-title":"Quantifying osteoblast apoptosis: challenges and rewards","volume":"22","author":"Jilka","year":"2007","journal-title":"J Bone Min Res."},{"key":"2024020318054603400_bib52","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1002\/jbmr.5650050402","article-title":"Cancellous bone remodeling in type I (postmenopausal) osteoporosis: quantitative assessment of rates of formation, resorption and bone loss at tissue and cellular levels","volume":"5","author":"Eriksen","year":"1990","journal-title":"J Bone Min Res."},{"key":"2024020318054603400_bib53","first-page":"389","volume-title":"Bone Histomorphometry: Third International Workshop","author":"Flora","year":"1981"},{"key":"2024020318054603400_bib54","volume-title":"Skeletal heterogeneity and the purposes of bone remodeling: implications for the understanding of osteoporosis. Osteoporosis","author":"Parfitt","year":"2007","edition":"3rd Edition"},{"key":"2024020318054603400_bib55","first-page":"301","volume-title":"Osteoporosis","author":"Parfitt","year":"1987"},{"key":"2024020318054603400_bib56","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S8756-3282(02)00975-4","article-title":"Effects of vertebral bone fragility and bone formation rate on the mineralization levels of cancellous bone from white females","volume":"32","author":"Ciarelli","year":"2003","journal-title":"Bone."},{"key":"2024020318054603400_bib57","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1359\/jbmr.2000.15.4.621","article-title":"Perspective: true strength","volume":"15","author":"Weinstein","year":"2000","journal-title":"J Bone Min Res."},{"key":"2024020318054603400_bib58","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/S8756-3282(03)00236-9","article-title":"Is the paradigm shifting?","volume":"33","author":"Heaney","year":"2003","journal-title":"Bone."},{"key":"2024020318054603400_bib59","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/978-3-642-70709-4_13","volume-title":"Current Concepts of Bone Fragility","author":"Parfitt","year":"1986"},{"key":"2024020318054603400_bib60","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1002\/ar.10014","article-title":"Super-osteons (remodeling clusters) in the cortex of the femoral shaft: influence of age and gender","volume":"264","author":"Bell","year":"2001","journal-title":"Anat Rec."},{"key":"2024020318054603400_bib61","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/BF01880411","article-title":"Relationship between serum intact parathyroid hormone concentrations and bone remodeling in type i osteoporosis: evidence that skeletal sensitivity is increased","volume":"1","author":"Kotowicz","year":"1990","journal-title":"Osteoporosis Int."},{"key":"2024020318054603400_bib62","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1111\/j.1749-6632.1998.tb09563.x","article-title":"The role of IL-6 type cytokines and their receptors in bone","volume":"840","author":"Manolagas","year":"1998","journal-title":"Ann NY Acad Sci."},{"key":"2024020318054603400_bib63","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1172\/JCI200318859","article-title":"A crucial role for thiol antioxidants in estrogen-deficiency bone loss","volume":"112","author":"Lean","year":"2003","journal-title":"J Clin Invest."},{"key":"2024020318054603400_bib64","doi-asserted-by":"crossref","first-page":"27285","DOI":"10.1074\/jbc.M702810200","article-title":"Skeletal involution by age-associated oxidative stress and its acceleration by loss of sex steroids","volume":"282","author":"Almeida","year":"2007","journal-title":"J Biol Chem."},{"key":"2024020318054603400_bib65","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s00223-005-0043-6","article-title":"Differences in osteocyte density and bone histomorphometry between men and women and between healthy and osteoporotic subjects","author":"Mullender","year":"2005","journal-title":"Calt Tiss Int."},{"key":"2024020318054603400_bib66","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0221-8747(84)90065-1","article-title":"Reconstruction of the resorptive site in iliac trabecular bone \u2013 kinetic model for bone resorption in 20 normal individuals","volume":"5","author":"Eriksen","year":"1984","journal-title":"Metab Bone Dis Rel Res."}],"container-title":["Journal of Bone and Mineral Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbmr.239","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/26\/3\/475\/56558699\/239_ftp.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/26\/3\/475\/56558699\/239_ftp.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T14:53:09Z","timestamp":1710341589000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbmr\/article\/26\/3\/475-485\/7598064"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,9,2]]},"references-count":66,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2010,9,2]]},"published-print":{"date-parts":[[2011,3,1]]}},"URL":"https:\/\/doi.org\/10.1002\/jbmr.239","relation":{},"ISSN":["0884-0431","1523-4681"],"issn-type":[{"value":"0884-0431","type":"print"},{"value":"1523-4681","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2011,3,1]]},"published":{"date-parts":[[2010,9,2]]}}}