{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T09:56:58Z","timestamp":1792231018147,"version":"4.4.0"},"reference-count":61,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2014,10,27]],"date-time":"2014-10-27T00:00:00Z","timestamp":1414368000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,4,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>\u2003<\/jats:title>\n                    <jats:p>The objective of this study was to determine the benefits of combination treatment with mechanical support and targeted intra-arterial infusion of peripheral blood stem cells (PBSCs) mobilized by granulocyte\u2013colony stimulating factor (G-CSF) via the medial circumflex femoral artery on the progression of osteonecrosis of the femoral head (ONFH). Fifty-five patients (89 hips) with early and intermediate stage ONFH were recruited and randomly assigned to combination treatment or mechanical support treatment (control group). All hips received mechanical support treatment (porous tantalum rod implantation). Then, hips in the combination treatment group were performed targeted intra-arterial infusion of PBSCs. At each follow-up, Harris hip score (HHS) and Association Research Circulation Osseous (ARCO) classification were used to evaluate the symptoms and progression of osteonecrosis. Total hip arthroplasty (THA) was assessed as an endpoint at each follow-up. At 36 months, 9 of the 41 hips (21.95%) in the control group progressed to clinical failure and underwent THA whereas only 3 of the 48 hips (6.25%) in the combination treatment group required THA (p\u2009=\u20090.031). Kaplan-Meier survival analysis showed a significant difference in the survival time between the two groups (log-rank test; p\u2009=\u20090.025). Compared to the control group, combination treatment significantly improved the HHS at 36 months (p\u2009=\u20090.003). At the final follow-up examination, radiological progression was noted in 13 of 41 hips (31.71%) for the control group, but in only 4 of 48 hips (8.33%) for the combination treatment group (p\u2009=\u20090.005). The overall collapse rates were 15.15% (5\/33 hips) and 8.11% (3\/37 hips) in the control and combination treatment groups, respectively. Targeted intra-arterial infusion of PBSCs is capable of enhancing the efficacy of biomechanical support in the treatment of ONFH. This clinical trial confirmed that the combination treatment might be a safe and feasible choice for the treatment of early or intermediate stages of ONFH. \u00a9 2014 American Society for Bone and Mineral Research.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jbmr.2390","type":"journal-article","created":{"date-parts":[[2014,10,27]],"date-time":"2014-10-27T14:55:36Z","timestamp":1414421736000},"page":"647-656","source":"Crossref","is-referenced-by-count":64,"title":["Combination Treatment of Biomechanical Support and Targeted Intra-arterial Infusion of Peripheral Blood Stem Cells Mobilized by Granulocyte-Colony Stimulating Factor for the Osteonecrosis of the Femoral Head: A Randomized Controlled Clinical Trial"],"prefix":"10.1093","volume":"30","author":[{"given":"Qiang","family":"Mao","sequence":"first","affiliation":[{"name":"Zhejiang Chinese Medical University Hangzhou China"},{"name":"Department of Orthopaedic Surgery The First Affiliated Hospital of Zhejiang Chinese Medical University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weidong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery The Second Affiliated Hospital of Zhejiang Chinese Medical University Hangzhou China"},{"name":"Zhejiang Chinese Medical University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taotao","family":"Xu","sequence":"additional","affiliation":[{"name":"Institute of Orthopaedics and Traumatology of Zhejiang Province Hangzhou China"},{"name":"Zhejiang Chinese Medical University Hangzhou China"},{"name":"Department of Orthopaedic Surgery The First Affiliated Hospital of Zhejiang Chinese Medical University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanxing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Zhejiang Chinese Medical University Hangzhou China"},{"name":"Department of Orthopaedic Surgery The First Affiliated Hospital of Zhejiang Chinese Medical University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luwei","family":"Xiao","sequence":"additional","affiliation":[{"name":"Institute of Orthopaedics and Traumatology of Zhejiang Province Hangzhou China"},{"name":"Zhejiang Chinese Medical University Hangzhou China"},{"name":"Department of Orthopaedic Surgery The First Affiliated Hospital of Zhejiang Chinese Medical University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Rush University Medical Center Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongting","family":"Jin","sequence":"additional","affiliation":[{"name":"Institute of Orthopaedics and Traumatology of Zhejiang Province Hangzhou China"},{"name":"Zhejiang Chinese Medical University Hangzhou 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