{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T07:12:06Z","timestamp":1789456326749,"version":"build-2803163510"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2015,1,28]],"date-time":"2015-01-28T00:00:00Z","timestamp":1422403200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,8,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>\u2003<\/jats:title><jats:p>The pathophysiological mechanism of increased fractures in young adults with type 1 diabetes mellitus (T1DM) is unclear. We conducted a case-control study of trabecular bone microarchitecture and vertebral marrow adiposity in young women with T1DM. Thirty women with T1DM with a median age (range) age of 22.0 years (16.9, 36.1) attending one outpatient clinic with a median age at diagnosis of 9.7 years (0.46, 14.8) were compared with 28 age-matched healthy women who acted as controls. Measurements included MRI-based assessment of proximal tibial bone volume\/total volume (appBV\/TV), trabecular separation (appTb.Sp), vertebral bone marrow adiposity (BMA), and abdominal adipose tissue and biochemical markers of GH\/IGF-1 axis (IGF-1, IGFBP3, ALS) and bone turnover. Median appBV\/TV in cases and controls was 0.3 (0.22, 0.37) and 0.33 (0.26, 0.4), respectively (p\u2009=\u20090.018) and median appTb.Sp in T1DM was 2.59 (2.24, 3.38) and 2.32 (2.03, 2.97), respectively (p\u2009=\u20090.012). The median appBV\/TV was 0.28 (0.22, 0.33) in those cases with retinopathy (n\u2009=\u200915) compared with 0.33 (0.25, 0.37) in those without retinopathy (p\u2009=\u20090.02). Although median visceral adipose tissue in cases was higher than in controls at 5733 mm3 (2030, 11,144) and 3460 mm3 (1808, 6832), respectively (p\u2009=\u20090.012), there was no difference in median BMA, which was 31.1% (9.9, 59.9) and 26.3% (8.5, 49.8) in cases and controls, respectively (p\u2009=\u20090.2). Serum IGF-1 and ALS were also lower in cases, and the latter showed an inverse association to appTbSp (r\u2009=\u2009\u20130.30, p\u2009=\u20090.04). Detailed MRI studies in young women with childhood-onset T1DM have shown clear deficits in trabecular microarchitecture of the tibia. Underlying pathophysiological mechanisms may include a microvasculopathy. \u00a9 2015 American Society for Bone and Mineral Research.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jbmr.2465","type":"journal-article","created":{"date-parts":[[2015,1,28]],"date-time":"2015-01-28T10:45:04Z","timestamp":1422441904000},"page":"1386-1393","source":"Crossref","is-referenced-by-count":104,"title":["Deficits in Trabecular Bone Microarchitecture in Young Women With Type 1 Diabetes Mellitus"],"prefix":"10.1093","volume":"30","author":[{"given":"Naiemh","family":"Abdalrahaman","sequence":"first","affiliation":[{"name":"Developmental Endocrinology Research GroupSchool of MedicineUniversity of GlasgowGlasgowUK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christie","family":"McComb","sequence":"additional","affiliation":[{"name":"BHF Glasgow Cardiovascular Research CentreUniversity of GlasgowGlasgowUK"},{"name":"Clinical PhysicsNHS Greater Glasgow & ClydeGlasgowUK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John E","family":"Foster","sequence":"additional","affiliation":[{"name":"BHF Glasgow Cardiovascular Research CentreUniversity of GlasgowGlasgowUK"},{"name":"Clinical PhysicsNHS Greater Glasgow & ClydeGlasgowUK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"McLean","sequence":"additional","affiliation":[{"name":"Institute of Neurological SciencesSouthern General HospitalGlasgowUK"},{"name":"Clinical PhysicsNHS Greater Glasgow & ClydeGlasgowUK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert S","family":"Lindsay","sequence":"additional","affiliation":[{"name":"Stobhill Diabetes CentreStobhill HospitalGlasgowUK"},{"name":"BHF Glasgow Cardiovascular Research CentreUniversity of GlasgowGlasgowUK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"McClure","sequence":"additional","affiliation":[{"name":"BHF Glasgow Cardiovascular Research CentreUniversity of GlasgowGlasgowUK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"McMillan","sequence":"additional","affiliation":[{"name":"Developmental Endocrinology Research GroupSchool of MedicineUniversity of GlasgowGlasgowUK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell","family":"Drummond","sequence":"additional","affiliation":[{"name":"Stobhill Diabetes CentreStobhill HospitalGlasgowUK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek","family":"Gordon","sequence":"additional","affiliation":[{"name":"Stobhill Diabetes CentreStobhill HospitalGlasgowUK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard A","family":"McKay","sequence":"additional","affiliation":[{"name":"Stobhill Diabetes CentreStobhill HospitalGlasgowUK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M Guftar","family":"Shaikh","sequence":"additional","affiliation":[{"name":"Developmental Endocrinology Research GroupSchool of MedicineUniversity of GlasgowGlasgowUK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin G","family":"Perry","sequence":"additional","affiliation":[{"name":"Stobhill Diabetes CentreStobhill HospitalGlasgowUK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S Faisal","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Developmental Endocrinology Research GroupSchool of MedicineUniversity of GlasgowGlasgowUK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,1,28]]},"reference":[{"key":"2024020319055629800_jbmr2465-bib-0001","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1007\/s001250051248","article-title":"Diabetes mellitus and the incidence of hip fracture: results from the Nord-Tr\u00f8ndelag Health Survey","volume":"42","author":"Fors\u00e9n","year":"1999","journal-title":"Diabetologia."},{"key":"2024020319055629800_jbmr2465-bib-0002","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.2337\/diacare.24.7.1192","article-title":"Iowa Women's Health Study. 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