{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T06:49:07Z","timestamp":1792651747008,"version":"4.5.0"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2015,3,7]],"date-time":"2015-03-07T00:00:00Z","timestamp":1425686400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,9,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>\u2003<\/jats:title>\n                    <jats:p>Nonsurgical hypoparathyroidism (HypoPT) is a rare disorder most often caused by mutations in different genes. It is characterized by hypocalcaemia with inappropriately low PTH levels. Knowledge about this group of patients, including their mortality and morbidity, is very sparse. The aim was to identify all patients diagnosed with nonsurgical HypoPT in Denmark and assess their mortality and risk of complications. Through registers and review of individual patient hospital charts we identified all patients diagnosed with nonsurgical HypoPT in Denmark between 1977 and 2012. We assessed their mortality and morbidity by comparing them with a group of age- and gender-matched population-based controls. We identified a total of 180 patients with nonsurgical HypoPT among whom 123 (68%) were alive at the date of follow-up (prevalence of 2.3\/100,000 inhabitants). Compared with controls, mortality was not increased, but patients had a significantly increased risk of renal insufficiency (hazard ratio [HR] 6.01), cardiovascular diseases (HR 1.91), neuropsychiatric complications (HR 2.45), infections (HR 1.94), seizures (HR 10.05), cataract (HR 4.21), and fractures at the upper extremities (HR 1.93). In contrast patients had significantly reduced risk of malignant diseases (HR 0.44). In conclusion, nonsurgical HypoPT is a rare disease associated with a number of complications that should be considered when taking care of these patients. \u00a9 2015 American Society for Bone and Mineral Research.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jbmr.2501","type":"journal-article","created":{"date-parts":[[2015,3,7]],"date-time":"2015-03-07T01:25:40Z","timestamp":1425691540000},"page":"1738-1744","source":"Crossref","is-referenced-by-count":221,"title":["The Epidemiology of Nonsurgical Hypoparathyroidism in Denmark: A Nationwide Case Finding Study"],"prefix":"10.1093","volume":"30","author":[{"given":"Line","family":"Underbjerg","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Internal MedicineTage-Hansens Gade (THG), Aarhus University HospitalAarhusDenmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanja","family":"Sikjaer","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Internal MedicineTage-Hansens Gade (THG), Aarhus University HospitalAarhusDenmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leif","family":"Mosekilde","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Internal MedicineTage-Hansens Gade (THG), Aarhus University HospitalAarhusDenmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Rejnmark","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Internal MedicineTage-Hansens Gade (THG), Aarhus University HospitalAarhusDenmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,3,7]]},"reference":[{"key":"2024020319032106700_jbmr2501-bib-0001","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1002\/jbmr.483","article-title":"Hypoparathyroidism in the adult: epidemiology, diagnosis, pathophysiology, target organ involvement, treatment, and challenges for future research","author":"Bilezikian","year":"2011","journal-title":"J Bone Miner Res."},{"key":"2024020319032106700_jbmr2501-bib-0002","doi-asserted-by":"crossref","first-page":"29","DOI":"10.2188\/jea.10.29","article-title":"Prevalence of idiopathic hypoparathyroidism and pseudohypoparathyroidism in Japan","author":"Nakamura","year":"2000","journal-title":"J Epidemiol."},{"key":"2024020319032106700_jbmr2501-bib-0003","article-title":"Co-morbid medical conditions associated with prevalent hypoparathyroidism: a population-based study","author":"Clarke","year":"2011","journal-title":"J Bone Miner Res."},{"key":"2024020319032106700_jbmr2501-bib-0004","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1002\/jbmr.1979","article-title":"Cardiovascular and renal complications to postsurgical hypoparathyroidism: a Danish nationwide controlled historic follow-up study","author":"Underbjerg","year":"2013","journal-title":"J Bone Miner Res."},{"key":"2024020319032106700_jbmr2501-bib-0005","doi-asserted-by":"crossref","first-page":"2504","DOI":"10.1002\/jbmr.2273","article-title":"Postsurgical hypoparathyroidism\u2014risk of fractures, psychiatric diseases, cancer, cataract, and infections","author":"Underbjerg","year":"2014","journal-title":"J Bone Miner Res."},{"key":"2024020319032106700_jbmr2501-bib-0006","first-page":"263","article-title":"The Danish National Hospital Register. 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