{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T14:00:08Z","timestamp":1789653608838,"version":"4.0.0"},"reference-count":59,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2015,4,13]],"date-time":"2015-04-13T00:00:00Z","timestamp":1428883200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>\u2003<\/jats:title>\n                  <jats:p>There is increasing evidence that bone and vascular calcification share common pathogenesis. Little is known about potential links between bone and valvular calcification. The purpose of this study was to determine the association between spine bone mineral density (BMD) and vascular and valvular calcification. Participants included 1317 participants (689 women, 628 men) in the Framingham Offspring Study (mean age 60 years). Integral, trabecular, and cortical volumetric bone density (vBMD) and arterial and valvular calcification were measured from computed tomography (CT) scans and categorized by sex-specific quartiles (Q4\u2009=\u2009high vBMD). Calcification of the coronary arteries (CAC), abdominal aorta (AAC), aortic valve (AVC), and mitral valve (MVC) were quantified using the Agatston Score (AS). Prevalence of any calcium (AS &amp;gt;0) was 69% for CAC, 81% for AAC, 39% for AVC, and 20% for MVC. In women, CAC increased with decreasing quartile of trabecular vBMD: adjusted mean CAC\u2009=\u20092.1 (Q4), 2.2 (Q3), 2.5 (Q2), 2.6 (Q1); trend p\u2009=\u20090.04. However, there was no inverse trend between CAC and trabecular vBMD in men: CAC\u2009=\u20094.3 (Q4), 4.3 (Q3), 4.2 (Q2), 4.3 (Q1); trend p\u2009=\u20090.92. AAC increased with decreasing quartile of trabecular vBMD in both women (AAC\u2009=\u20094.5 [Q4], 4.8 [Q3], 5.4 [Q2], 5.1 [Q1]; trend p\u2009=\u20090.01) and men (AAC\u2009=\u20095.5 [Q4], 5.8 [Q3], 5.9 [Q2], 6.2 [Q1]; trend p\u2009=\u20090.01). We observed no association between trabecular vBMD and AVC or MVC in women or men. Finally, cortical vBMD was unrelated to vascular calcification and valvular calcification in women and men. Women and men with low spine vBMD have greater severity of vascular calcification, particularly at the abdominal aorta. The inverse relation between AAC and spine vBMD in women and men may be attributable to shared etiology and may be an important link on which to focus treatment efforts that can target individuals at high risk of both fracture and cardiovascular events. \u00a9 2015 American Society for Bone and Mineral Research.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/jbmr.2530","type":"journal-article","created":{"date-parts":[[2015,4,13]],"date-time":"2015-04-13T09:22:45Z","timestamp":1428916965000},"page":"1767-1774","source":"Crossref","is-referenced-by-count":50,"title":["QCT Volumetric Bone Mineral Density and Vascular and Valvular Calcification: The Framingham Study"],"prefix":"10.1093","volume":"30","author":[{"given":"Jimmy J","family":"Chan","sequence":"first","affiliation":[{"name":"Albert Einstein College of MedicineBronx NYUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L Adrienne","family":"Cupples","sequence":"additional","affiliation":[{"name":"National Heart, Lung, and Blood Institute's Framingham Heart StudyFraminghamMAUSA"},{"name":"Boston University School of Public HealthBostonMAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas P","family":"Kiel","sequence":"additional","affiliation":[{"name":"Beth Israel Deaconess Medical CenterBostonMAUSA"},{"name":"Institute for Aging Research, Hebrew SeniorLifeBostonMAUSA"},{"name":"Harvard Medical SchoolBostonMAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J","family":"O'Donnell","sequence":"additional","affiliation":[{"name":"Massachusetts General HospitalBostonMAUSA"},{"name":"Harvard Medical SchoolBostonMAUSA"},{"name":"National Heart, Lung, and Blood Institute's Framingham Heart StudyFraminghamMAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Udo","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"Massachusetts General HospitalBostonMAUSA"},{"name":"Harvard Medical SchoolBostonMAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth J","family":"Samelson","sequence":"additional","affiliation":[{"name":"Beth Israel Deaconess Medical CenterBostonMAUSA"},{"name":"Institute for Aging Research, Hebrew SeniorLifeBostonMAUSA"},{"name":"Harvard Medical SchoolBostonMAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,4,13]]},"reference":[{"issue":"22","key":"2024020319030367200_jbmr2530-bib-0001","doi-asserted-by":"crossref","first-page":"2491","DOI":"10.1016\/j.jacc.2010.03.019","article-title":"Associations of long-term and early adult atherosclerosis risk factors with aortic and mitral valve 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