{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T19:49:40Z","timestamp":1791748180899,"version":"4.3.4"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2015,5,19]],"date-time":"2015-05-19T00:00:00Z","timestamp":1431993600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,11,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>\u2003<\/jats:title>\n                    <jats:p>Teriparatide, a recombinant peptide corresponding to amino acids 1-34 of human parathyroid hormone (PTH), has been an effective bone anabolic drug for over a decade. However, the mechanism whereby PTH stimulates bone formation remains incompletely understood. Here we report that in cultures of osteoblast-lineage cells, PTH stimulates glucose consumption and lactate production in the presence of oxygen, a hallmark of aerobic glycolysis, also known as Warburg effect. Experiments with radioactively labeled glucose demonstrate that PTH suppresses glucose entry into the tricarboxylic acid cycle (TCA cycle). Mechanistically, the increase in aerobic glycolysis is secondary to insulin-like growth factor (Igf) signaling induced by PTH, whereas the metabolic effect of Igf is dependent on activation of mammalian target of rapamycin complex 2 (mTORC2). Importantly, pharmacological perturbation of glycolysis suppresses the bone anabolic effect of intermittent PTH in the mouse. Thus, stimulation of aerobic glycolysis via Igf signaling contributes to bone anabolism in response to PTH. \u00a9 2015 American Society for Bone and Mineral Research.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jbmr.2556","type":"journal-article","created":{"date-parts":[[2015,5,19]],"date-time":"2015-05-19T18:39:45Z","timestamp":1432060785000},"page":"1959-1968","source":"Crossref","is-referenced-by-count":143,"title":["PTH Promotes Bone Anabolism by Stimulating Aerobic Glycolysis via IGF Signaling"],"prefix":"10.1093","volume":"30","author":[{"given":"Emel","family":"Esen","sequence":"first","affiliation":[{"name":"Department of Orthopaedic SurgeryWashington University School of MedicineSt. LouisMOUSA"},{"name":"Division of Biology and Biomedical SciencesWashington University School of MedicineSt. LouisMOUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung-Yon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic SurgeryWashington University School of MedicineSt. LouisMOUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burton M","family":"Wice","sequence":"additional","affiliation":[{"name":"Department of MedicineWashington University School of MedicineSt. LouisMOUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanxin","family":"Long","sequence":"additional","affiliation":[{"name":"Department of Developmental BiologyWashington University School of MedicineSt. LouisMOUSA"},{"name":"Department of MedicineWashington University School of MedicineSt. LouisMOUSA"},{"name":"Department of Orthopaedic SurgeryWashington University School of MedicineSt. LouisMOUSA"},{"name":"Division of Biology and Biomedical SciencesWashington University School of MedicineSt. LouisMOUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,5,19]]},"reference":[{"issue":"5","key":"2024020319012378700_jbmr2556-bib-0001","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1210\/er.2004-0006","article-title":"Parathyroid hormone and teriparatide for the treatment of osteoporosis: a review of the evidence and suggested guidelines for its use","volume":"26","author":"Hodsman","year":"2005","journal-title":"Endocr Rev."},{"issue":"6","key":"2024020319012378700_jbmr2556-bib-0002","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1016\/j.bone.2007.03.017","article-title":"Molecular and cellular mechanisms of the anabolic effect of intermittent PTH","volume":"40","author":"Jilka","year":"2007","journal-title":"Bone."},{"issue":"50","key":"2024020319012378700_jbmr2556-bib-0003","doi-asserted-by":"crossref","first-page":"50259","DOI":"10.1074\/jbc.M307444200","article-title":"Proteasomal degradation of Runx2 shortens parathyroid hormone-induced anti-apoptotic signaling in osteoblasts. A putative explanation for why intermittent administration is needed for bone anabolism","volume":"278","author":"Bellido","year":"2003","journal-title":"J Biol Chem."},{"issue":"10","key":"2024020319012378700_jbmr2556-bib-0004","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1002\/jbmr.1665","article-title":"Intermittent parathyroid hormone administration converts quiescent lining cells to active osteoblasts","volume":"27","author":"Kim","year":"2012","journal-title":"J Bone Miner Res."},{"issue":"8","key":"2024020319012378700_jbmr2556-bib-0005","doi-asserted-by":"crossref","first-page":"3632","DOI":"10.1210\/endo.136.8.7628403","article-title":"Evidence that intermittent treatment with parathyroid hormone increases bone formation in adult rats by activation of bone lining 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