{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T11:11:31Z","timestamp":1788952291202,"version":"build-2803163510"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2015,5,19]],"date-time":"2015-05-19T00:00:00Z","timestamp":1431993600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,11,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>\u2003<\/jats:title>\n                  <jats:p>Wrist fractures are common in postmenopausal women and are associated with functional decline. Fracture patterns after wrist fracture are unclear. The goal of this study was to determine the frequency and types of fractures that occur after a wrist fracture among postmenopausal women. We carried out a post hoc analysis of data from the Women's Health Initiative Observational Study and Clinical Trials (1993\u20132010) carried out at 40 US clinical centers. Participants were postmenopausal women aged 50 to 79 years at baseline. Mean follow-up duration was 11.8 years. Main measures included incident wrist, clinical spine, humerus, upper extremity, lower extremity, hip, and total non-wrist fractures and bone mineral density (BMD) in a subset. Among women who experienced wrist fracture, 15.5% subsequently experienced non-wrist fracture. The hazard for non-wrist fractures was higher among women who had experienced previous wrist fracture than among women who had not experienced wrist fracture: non-wrist fracture overall (hazard ratio [HR]\u2009=\u20091.40, 95% confidence interval [CI] 1.33\u20131.48), spine (HR\u2009=\u20091.48, 95% CI 1.32\u20131.66), humerus (HR\u2009=\u20091.78, 95% CI 1.57\u20132.02), upper extremity (non-wrist) (HR\u2009=\u20091.88, 95% CI 1.70\u20132.07), lower extremity (non-hip) (HR\u2009=\u20091.36, 95% CI 1.26\u20131.48), and hip (HR\u2009=\u20091.50, 95% CI 1.32\u20131.71) fracture. Associations persisted after adjustment for BMD, physical activity, and other risk factors. Risk of non-wrist fracture was higher in women who were younger when they experienced wrist fracture (interaction p value 0.02). Associations between incident wrist fracture and subsequent non-wrist fracture did not vary by baseline BMD category (normal, low bone density, osteoporosis). A wrist fracture is associated with increased risk of subsequent hip, vertebral, upper extremity, and lower extremity fractures. There may be substantial missed opportunity for intervention in the large number of women who present with wrist fractures. \u00a9 2015 American Society for Bone and Mineral Research.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/jbmr.2559","type":"journal-article","created":{"date-parts":[[2015,5,19]],"date-time":"2015-05-19T23:23:15Z","timestamp":1432077795000},"page":"2086-2095","source":"Crossref","is-referenced-by-count":64,"title":["Wrist Fracture and Risk of Subsequent Fracture: Findings from the Women's Health Initiative Study"],"prefix":"10.1093","volume":"30","author":[{"given":"Carolyn J","family":"Crandall","sequence":"first","affiliation":[{"name":"Department of MedicineDavid Geffen School of Medicine at the University of California at Los AngelesLos AngelesCAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen M","family":"Hovey","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Environmental HealthState University of New York at BuffaloBuffaloNYUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane A","family":"Cauley","sequence":"additional","affiliation":[{"name":"Department of EpidemiologyUniversity of Pittsburgh, Graduate School of Public HealthPittsburghPAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher A","family":"Andrews","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual SciencesUniversity of MichiganAnn ArborMIUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey R","family":"Curtis","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology and RheumatologyUniversity of Alabama at BirminghamBirmingham ALUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Wactawski-Wende","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Environmental HealthState University of New York at BuffaloBuffaloNYUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole C","family":"Wright","sequence":"additional","affiliation":[{"name":"Department of EpidemiologyUniversity of Alabama at BirminghamBirminghamAlabamaUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjun","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Preventive and Behavioral MedicineUniversity of Massachusetts Medical SchoolWorcesterMAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meryl S","family":"LeBoff","sequence":"additional","affiliation":[{"name":"Department of Medicine, Endocrine, Diabetes and Hypertension DivisionBrigham and Women's Hospital, Harvard Medical SchoolBostonMAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,5,19]]},"reference":[{"key":"2024020319013540200_jbmr2559-bib-0001","first-page":"37","article-title":"Melton LJ 3rd, Ilstrup DM, Johnson KA, Riggs BL. Colles' fracture and subsequent hip fracture risk","author":"Owen","year":"1982","journal-title":"Clin Orthop Relat Res."},{"issue":"7","key":"2024020319013540200_jbmr2559-bib-0002","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1007\/s00198-009-1047-2","article-title":"Assessing forearm fracture risk in postmenopausal women","volume":"21","author":"Melton","year":"2010","journal-title":"Osteoporos Int."},{"issue":"1","key":"2024020319013540200_jbmr2559-bib-0003","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1136\/ip.2010.026799","article-title":"Epidemiology of fall related forearm and wrist fractures among adults treated in US hospital emergency departments","volume":"17","author":"Orces","year":"2011","journal-title":"Inj Prev."},{"issue":"5","key":"2024020319013540200_jbmr2559-bib-0004","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/BF01623352","article-title":"Symptomatic fracture incidence in elderly men and women: the Dubbo Osteoporosis Epidemiology Study (DOES)","volume":"4","author":"Jones","year":"1994","journal-title":"Osteoporos Int."},{"issue":"3","key":"2024020319013540200_jbmr2559-bib-0005","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1002\/jbmr.2072","article-title":"Melton LJ 3rd. Trends in fracture incidence: a population-based study over 20 years","volume":"29","author":"Amin","year":"2014","journal-title":"J Bone Miner Res."},{"issue":"3","key":"2024020319013540200_jbmr2559-bib-0006","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1002\/jbmr.2370","article-title":"The 21st-century landscape of adult fractures: cohort study of a complete adult regional population","volume":"30","author":"Rosengren","year":"2015","journal-title":"J Bone Miner Res."},{"issue":"3","key":"2024020319013540200_jbmr2559-bib-0007","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/S0272-2712(18)30046-5","article-title":"Epidemiology of fractures and assessment of fracture risk","volume":"20","author":"Black","year":"2000","journal-title":"Clin Lab Med."},{"key":"2024020319013540200_jbmr2559-bib-0008","doi-asserted-by":"crossref","first-page":"S81","DOI":"10.1007\/s40520-013-0083-0","article-title":"The clinical significance of wrist fracture in osteoporosis","volume":"25","author":"Cerocchi","year":"2013","journal-title":"Aging Clin Exp Res."},{"key":"2024020319013540200_jbmr2559-bib-0009","doi-asserted-by":"crossref","first-page":"c3324","DOI":"10.1136\/bmj.c3324","article-title":"Functional decline after incident wrist fractures\u2014Study of Osteoporotic Fractures: prospective cohort study","volume":"341","author":"Edwards","year":"2010","journal-title":"BMJ"},{"issue":"8","key":"2024020319013540200_jbmr2559-bib-0010","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.jamda.2009.12.004","article-title":"Is withholding osteoporosis medication after fracture sometimes rational? A comparison of the risk for second fracture versus death","volume":"11","author":"Curtis","year":"2010","journal-title":"J Am Med Dir Assoc."},{"key":"2024020319013540200_jbmr2559-bib-0011","article-title":"National Osteoporosis Foundation. Clinician's guide to prevention and treatment of osteoporosis. Washington","year":"2014","journal-title":"DC: National Osteoporosis Foundation"},{"issue":"5","key":"2024020319013540200_jbmr2559-bib-0012","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1007\/s00198-014-2655-z","article-title":"The clinical diagnosis of osteoporosis: a position statement from the National Bone Health Alliance Working Group","volume":"25","author":"Siris","year":"2014","journal-title":"Osteoporos Int."},{"issue":"2","key":"2024020319013540200_jbmr2559-bib-0013","first-page":"156","article-title":"Radial fracture as an indicator of osteoporosis: a 10-year follow-up study","volume":"111","author":"Gay","year":"1974","journal-title":"Can Med Assoc J"},{"issue":"1","key":"2024020319013540200_jbmr2559-bib-0014","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1097\/TA.0b013e31824bb325","article-title":"Incidence of subsequent hip fractures is significantly increased within the first month after distal radius fracture in patients older than 60 years","volume":"74","author":"Chen","year":"2013","journal-title":"J Trauma Acute Care Surg."},{"issue":"3","key":"2024020319013540200_jbmr2559-bib-0015","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/BF01623274","article-title":"Radial and humeral fractures as predictors of subsequent hip, radial or humeral fractures in women, and their seasonal variation","volume":"3","author":"Lauritzen","year":"1993","journal-title":"Osteoporos Int."},{"issue":"6","key":"2024020319013540200_jbmr2559-bib-0016","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/s001980050172","article-title":"Melton LJ 3rd. Forearm fractures as predictors of subsequent osteoporotic fractures","volume":"9","author":"Cuddihy","year":"1999","journal-title":"Osteoporos Int"},{"issue":"5","key":"2024020319013540200_jbmr2559-bib-0017","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1007\/s00198-007-0508-8","article-title":"Wrist fracture as a predictor of future fractures in younger versus older postmenopausal women: results from the National Osteoporosis Risk Assessment (NORA)","volume":"19","author":"Barrett-Connor","year":"2008","journal-title":"Osteoporos Int."},{"issue":"22","key":"2024020319013540200_jbmr2559-bib-0018","doi-asserted-by":"crossref","first-page":"2815","DOI":"10.1001\/jama.286.22.2815","article-title":"Identification and fracture outcomes of undiagnosed low bone mineral density in postmenopausal women: results from the National Osteoporosis Risk Assessment","volume":"286","author":"Siris","year":"2001","journal-title":"JAMA"},{"issue":"1","key":"2024020319013540200_jbmr2559-bib-0019","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0197-2456(97)00078-0","article-title":"Design of the Women's Health Initiative clinical trial and observational study. The Women's Health Initiative Study Group","volume":"19","year":"1998","journal-title":"Control Clin Trials."},{"key":"2024020319013540200_jbmr2559-bib-0020","doi-asserted-by":"crossref","first-page":"S107","DOI":"10.1016\/S1047-2797(03)00047-4","article-title":"The Women's Health Initiative Observational Study: baseline characteristics of participants and reliability of baseline measures","volume":"13","author":"Langer","year":"2003","journal-title":"Ann Epidemiol."},{"issue":"12","key":"2024020319013540200_jbmr2559-bib-0021","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1007\/s00198-008-0634-y","article-title":"Incidence of fractures compared to cardiovascular disease and breast cancer: the Women's Health Initiative Observational Study","volume":"19","author":"Cauley","year":"2008","journal-title":"Osteoporos Int."},{"key":"2024020319013540200_jbmr2559-bib-0022","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1016\/S1047-2797(03)00043-7","article-title":"Implementation of the Women's Health Initiative study design","volume":"13","author":"Anderson","year":"2003","journal-title":"Ann Epidemiol."},{"issue":"8","key":"2024020319013540200_jbmr2559-bib-0023","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1359\/jbmr.090307","article-title":"Does obesity really make the femur stronger? BMD, geometry, and fracture incidence in the Women's Health Initiative observational study","volume":"24","author":"Beck","year":"2009","journal-title":"J Bone Miner Res."},{"issue":"6","key":"2024020319013540200_jbmr2559-bib-0024","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1007\/s00198-009-1056-1","article-title":"Hip structural geometry and incidence of hip fracture in postmenopausal women: what does it add to conventional bone mineral density?","volume":"21","author":"LaCroix","year":"2010","journal-title":"Osteoporos Int."},{"issue":"5","key":"2024020319013540200_jbmr2559-bib-0025","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1002\/cncr.23674","article-title":"Hip bone density predicts breast cancer risk independently of Gail score: results from the Women's Health Initiative","volume":"113","author":"Chen","year":"2008","journal-title":"Cancer."},{"issue":"3","key":"2024020319013540200_jbmr2559-bib-0026","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1097\/01.GME.0000094210.15096.FD","article-title":"Validity of self-report for fractures among a multiethnic cohort of postmenopausal women: results from the Women's Health Initiative observational study and clinical trials","volume":"11","author":"Chen","year":"2004","journal-title":"Menopause."},{"issue":"10","key":"2024020319013540200_jbmr2559-bib-0027","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1056\/NEJMoa021067","article-title":"Walking compared with vigorous exercise for the prevention of cardiovascular events in women","volume":"347","author":"Manson","year":"2002","journal-title":"N Engl J Med."},{"issue":"3","key":"2024020319013540200_jbmr2559-bib-0028","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/S1047-2797(98)00055-6","article-title":"Measurement characteristics of the Women's Health Initiative food frequency questionnaire","volume":"9","author":"Patterson","year":"1999","journal-title":"Ann Epidemiol."},{"issue":"6","key":"2024020319013540200_jbmr2559-bib-0029","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1097\/00005650-199206000-00002","article-title":"The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection","volume":"30","author":"Ware","year":"1992","journal-title":"Med Care."},{"issue":"3","key":"2024020319013540200_jbmr2559-bib-0030","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1002\/hec.4730020305","article-title":"The RAND 36-Item Health Survey 1. 0","volume":"2","author":"Hays","year":"1993","journal-title":"Health Econ"},{"issue":"4","key":"2024020319013540200_jbmr2559-bib-0031","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/s00198-007-0543-5","article-title":"FRAX and the assessment of fracture probability in men and women from the UK","volume":"19","author":"Kanis","year":"2008","journal-title":"Osteoporos Int."},{"issue":"8","key":"2024020319013540200_jbmr2559-bib-0032","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1007\/s11606-008-0622-0","article-title":"Does a history of non-vertebral fracture identify women without osteoporosis for treatment?","volume":"23","author":"Ryder","year":"2008","journal-title":"J Gen Intern Med."}],"container-title":["Journal of Bone and Mineral Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbmr.2559","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/30\/11\/2086\/56567417\/jbmr2559.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/30\/11\/2086\/56567417\/jbmr2559.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T14:54:25Z","timestamp":1710341665000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbmr\/article\/30\/11\/2086-2095\/7599158"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,19]]},"references-count":32,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2015,5,19]]},"published-print":{"date-parts":[[2015,11,1]]}},"URL":"https:\/\/doi.org\/10.1002\/jbmr.2559","relation":{},"ISSN":["0884-0431","1523-4681"],"issn-type":[{"value":"0884-0431","type":"print"},{"value":"1523-4681","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2015,11,1]]},"published":{"date-parts":[[2015,5,19]]}}}