{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:00:19Z","timestamp":1791349219121,"version":"4.3.1"},"reference-count":61,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2015,6,8]],"date-time":"2015-06-08T00:00:00Z","timestamp":1433721600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,12,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>\u2003<\/jats:title>\n                  <jats:p>The diagnosis of fracture risk relies almost solely on quantifying bone mass, yet bone strength is governed by factors at multiple scales including composition and structure that contribute to fracture resistance. Furthermore, aging and conditions such as diabetes mellitus alter fracture incidence independently of bone mass. Therefore, it is critical to incorporate other factors that contribute to bone strength in order to improve diagnostic specificity of fracture risk. We examined the correlation between femoral neck fracture strength in aging female cadavers and areal bone mineral density, along with other clinically accessible measures of bone quality including whole-bone cortical porosity (Ct.Po), bone material mechanical behavior measured by reference point indentation (RPI), and accumulation of advanced glycation end-products (AGEs). All measurements were found to be significant predictors of femoral neck fracture strength, with areal bone mineral density (aBMD) being the single strongest correlate (aBMD: r\u2009=\u20090.755, p\u2009&amp;lt;\u20090.001; Ct.Po: r\u2009=\u2009\u20130.500, p\u2009&amp;lt;\u20090.001; RPI: r\u2009=\u2009\u20130.478, p\u2009&amp;lt;\u20090.001; AGEs: r\u2009=\u2009\u20130.336, p\u2009=\u20090.016). RPI-derived measurements were not correlated with tissue mineral density or local cortical porosity as confirmed by micro\u2013computed tomography (\u03bcCT). Multiple reverse stepwise regression revealed that the inclusion of aBMD and any other factor significantly improve the prediction of bone strength over univariate predictions. Combining bone assays at multiple scales such as aBMD with tibial Ct.Po (r\u2009=\u20090.835; p\u2009&amp;lt;\u20090.001), tibial difference in indentation depth between the first and 20th cycle (IDI) (r\u2009=\u20090.883; p\u2009&amp;lt;\u20090.001), or tibial AGEs (r\u2009=\u20090.822; p\u2009&amp;lt;\u20090.001) significantly improves the prediction of femoral neck strength over any factor alone, suggesting that this personalized approach could greatly enhance bone strength and fracture risk assessment with the potential to guide clinical management strategies for at-risk populations. \u00a9 2015 American Society for Bone and Mineral Research.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/jbmr.2568","type":"journal-article","created":{"date-parts":[[2015,6,9]],"date-time":"2015-06-09T16:53:36Z","timestamp":1433868816000},"page":"2207-2214","source":"Crossref","is-referenced-by-count":56,"title":["Multiscale Predictors of Femoral Neck In Situ Strength in Aging Women: Contributions of BMD, Cortical Porosity, Reference Point Indentation, and Nonenzymatic Glycation"],"prefix":"10.1093","volume":"30","author":[{"given":"Adam C","family":"Abraham","sequence":"first","affiliation":[{"name":"Department of Orthopaedic SurgeryWashington University in St. LouisSt. LouisMOUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avinesh","family":"Agarwalla","sequence":"additional","affiliation":[{"name":"Department of Biomedical EngineeringWashington University in St. LouisSt. LouisMOUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aditya","family":"Yadavalli","sequence":"additional","affiliation":[{"name":"Department of Biomedical EngineeringWashington University in St. LouisSt. LouisMOUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"McAndrew","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic SurgeryWashington University in St. LouisSt. LouisMOUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny Y","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic SurgeryWashington University in St. LouisSt. LouisMOUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon Y","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering and Materials ScienceWashington University in St. LouisSt. LouisMOUSA"},{"name":"Department of Biomedical EngineeringWashington University in St. LouisSt. LouisMOUSA"},{"name":"Department of Orthopaedic SurgeryWashington University in St. LouisSt. LouisMOUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,6,8]]},"reference":[{"issue":"5","key":"2024020319003312100_jbmr2568-bib-0001","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/s00198-003-1385-4","article-title":"Cost-equivalence of different osteoporotic fractures","volume":"14","author":"Melton","year":"2003","journal-title":"Osteoporos Int."},{"issue":"7418","key":"2024020319003312100_jbmr2568-bib-0002","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1136\/bmj.327.7418.771","article-title":"Time trends and demography of mortality after fractured neck of femur in an English population, 1968\u201398: database study","volume":"327","author":"Roberts","year":"2003","journal-title":"BMJ."},{"issue":"3","key":"2024020319003312100_jbmr2568-bib-0003","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1046\/j.1532-5415.2003.51110.x","article-title":"Estimating hip fracture morbidity, mortality and costs","volume":"51","author":"Braithwaite","year":"2003","journal-title":"J Am Geriatr Soc."},{"issue":"14","key":"2024020319003312100_jbmr2568-bib-0004","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1001\/jama.2009.1462","article-title":"Incidence and mortality of hip fractures in the United States","volume":"302","author":"Brauer","year":"2009","journal-title":"JAMA."},{"issue":"1","key":"2024020319003312100_jbmr2568-bib-0005","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S1568-1637(02)00045-4","article-title":"Ronald MacKenzie C, Lane JM. Hip fractures among the elderly: causes, consequences and control","volume":"2","author":"Marks","year":"2003","journal-title":"Ageing Res Rev."},{"issue":"6","key":"2024020319003312100_jbmr2568-bib-0006","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1055\/s-0034-1384629","article-title":"Insights into the epidemiology of postmenopausal osteoporosis: The Women's Health Initiative","volume":"32","author":"Jackson","year":"2014","journal-title":"Semin Reprod Med."},{"issue":"2","key":"2024020319003312100_jbmr2568-bib-0007","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1007\/s11914-007-0004-2","article-title":"The role of the collagen matrix in skeletal fragility","volume":"5","author":"Vashishth","year":"2007","journal-title":"Curr Osteoporos Rep."},{"issue":"6","key":"2024020319003312100_jbmr2568-bib-0008","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1016\/j.bone.2006.06.001","article-title":"A biomechanical perspective on bone quality","volume":"39","author":"Hernandez","year":"2006","journal-title":"Bone."},{"issue":"Suppl 3","key":"2024020319003312100_jbmr2568-bib-0009","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.1007\/s00198-002-1345-4","article-title":"Bone strength and its determinants","volume":"14","author":"Ammann","year":"2003","journal-title":"Osteoporos Int."},{"issue":"6)","key":"2024020319003312100_jbmr2568-bib-0010","doi-asserted-by":"crossref","first-page":"331","DOI":"10.3949\/ccjm.76a.08041","article-title":"Bone density vs bone quality: what's a clinician to do?","volume":"76","author":"Licata","year":"2009","journal-title":"Cleve Clin J Med."},{"issue":"3)","key":"2024020319003312100_jbmr2568-bib-0011","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.bone.2007.06.010","article-title":"Is a change in bone mineral density a sensitive and specific surrogate of anti-fracture efficacy?","volume":"41","author":"Seeman","year":"2007","journal-title":"Bone."},{"issue":"December 1987","key":"2024020319003312100_jbmr2568-bib-0012","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1172\/JCI113523","article-title":"Age and bone mass as predictors of fracture in a prospective study","volume":"81","author":"Hui","year":"1988","journal-title":"J Clin Invest."},{"issue":"6","key":"2024020319003312100_jbmr2568-bib-0013","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1093\/rheumatology\/ket007","article-title":"Friend or foe: high bone mineral density on routine bone density scanning, a review of causes and management","volume":"52","author":"Gregson","year":"2013","journal-title":"Rheumatology (Oxford)."},{"issue":"6","key":"2024020319003312100_jbmr2568-bib-0014","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.2337\/dc12-1188","article-title":"High bone mineral density and fracture risk in type 2 diabetes as skeletal complications of inadequate glucose control: the Rotterdam Study","volume":"36","author":"Oei","year":"2013","journal-title":"Diabetes Care."},{"key":"2024020319003312100_jbmr2568-bib-0015","doi-asserted-by":"crossref","first-page":"2436","DOI":"10.1016\/j.jbiomech.2014.04.006","article-title":"Hyperlipidemia affects multiscale structure and strength of murine femur","volume":"47","author":"Ascenzi","year":"2014","journal-title":"J Biomech."},{"issue":"1","key":"2024020319003312100_jbmr2568-bib-0016","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1146\/annurev-matsci-070909-104427","article-title":"On the mechanistic origins of toughness in bone","volume":"40","author":"Launey","year":"2010","journal-title":"Annu Rev Mater Res."},{"issue":"6","key":"2024020319003312100_jbmr2568-bib-0017","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1063\/1.3156332","article-title":"Plasticity and toughness in bone","volume":"62","author":"Ritchie","year":"2009","journal-title":"Phys Today."},{"issue":"2","key":"2024020319003312100_jbmr2568-bib-0018","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.jbiomech.2010.10.016","article-title":"The relative contributions of non-enzymatic glycation and cortical porosity on the fracture toughness of aging bone","volume":"44","author":"Tang","year":"2011","journal-title":"J Biomech."},{"issue":"35","key":"2024020319003312100_jbmr2568-bib-0019","doi-asserted-by":"crossref","first-page":"14416","DOI":"10.1073\/pnas.1107966108","article-title":"Age-related changes in the plasticity and toughness of human cortical bone at multiple length scales","volume":"108","author":"Zimmermann","year":"2011","journal-title":"Proc Natl Acad Sci USA."},{"key":"2024020319003312100_jbmr2568-bib-0020","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1002\/jbmr.1497","article-title":"Parathyroid hormone treatment improves the cortical bone microstructure by improving the distribution of type I collagen in postmenopausal women with osteoporosis","volume":"27","author":"Ascenzi","year":"2012","journal-title":"J Bone Miner Res."},{"key":"2024020319003312100_jbmr2568-bib-0021","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/bonekey.2013.181","article-title":"Bone composition: relationship to bone fragility and antiosteoporotic drug effects","volume":"2","author":"Boskey","year":"2013","journal-title":"Bonekey Rep."},{"issue":"12","key":"2024020319003312100_jbmr2568-bib-0022","doi-asserted-by":"crossref","first-page":"6508","DOI":"10.1210\/jc.2005-1258","article-title":"In vivo assessment of trabecular bone microarchitecture by high-resolution peripheral quantitative computed tomography","volume":"90","author":"Boutroy","year":"2005","journal-title":"J Clin Endocrinol Metab."},{"issue":"4","key":"2024020319003312100_jbmr2568-bib-0023","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1359\/jbmr.090822","article-title":"High-resolution peripheral quantitative computed tomography can assess microstructural and mechanical properties of human distal tibial bone","volume":"25","author":"Liu","year":"2010","journal-title":"J Bone Miner Res."},{"issue":"2","key":"2024020319003312100_jbmr2568-bib-0024","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1002\/jbmr.1763","article-title":"Increased cortical porosity in type 2 diabetic postmenopausal women with fragility fractures","volume":"28","author":"Patsch","year":"2013","journal-title":"J Bone Miner Res."},{"issue":"5","key":"2024020319003312100_jbmr2568-bib-0025","doi-asserted-by":"crossref","first-page":"054303","DOI":"10.1063\/1.3127602","article-title":"The tissue diagnostic instrument","volume":"80","author":"Hansma","year":"2009","journal-title":"Rev Sci Instrum."},{"issue":"1","key":"2024020319003312100_jbmr2568-bib-0026","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1002\/jbmr.1731","article-title":"Microindentation for in vivo measurement of bone tissue material properties in atypical femoral fracture patients and controls","volume":"28","author":"G\u00fcerri-Fern\u00e1ndez","year":"2013","journal-title":"J Bone Miner Res."},{"issue":"10","key":"2024020319003312100_jbmr2568-bib-0027","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1016\/j.jbiomech.2013.04.003","article-title":"Reference point indentation study of age-related changes in porcine femoral cortical bone","volume":"46","author":"Rasoulian","year":"2013","journal-title":"J Biomech."},{"issue":"1)","key":"2024020319003312100_jbmr2568-bib-0028","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.bone.2012.12.015","article-title":"Reference-point indentation correlates with bone toughness assessed using whole-bone traditional mechanical testing","volume":"53","author":"Gallant","year":"2013","journal-title":"Bone."},{"issue":"4","key":"2024020319003312100_jbmr2568-bib-0029","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1016\/j.bone.2006.12.056","article-title":"Effects of non-enzymatic glycation on cancellous bone fragility","volume":"40","author":"Tang","year":"2007","journal-title":"Bone."},{"issue":"2","key":"2024020319003312100_jbmr2568-bib-0030","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S8756-3282(00)00434-8","article-title":"Influence of nonenzymatic glycation on biomechanical properties of cortical bone","volume":"28","author":"Vashishth","year":"2001","journal-title":"Bone."},{"issue":"12","key":"2024020319003312100_jbmr2568-bib-0031","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1359\/jbmr.040820","article-title":"Bone fragility and collagen cross-links","volume":"19","author":"Paschalis","year":"2004","journal-title":"J Bone Miner Res."},{"key":"2024020319003312100_jbmr2568-bib-0032","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/0021-9290(77)90045-8","article-title":"Age and sex-related changes in the structure and strength of the human femoral shaft","volume":"10","author":"Martin","year":"1977","journal-title":"J Biomech."},{"key":"2024020319003312100_jbmr2568-bib-0033","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1002\/jbmr.1614","article-title":"The interindividual variation in femoral neck width is associated with the acquisition of predictable sets of morphological and tissue-quality traits and differential bone loss patterns","volume":"27","author":"Epelboym","year":"2012","journal-title":"J Bone Miner Res."},{"issue":"3","key":"2024020319003312100_jbmr2568-bib-0034","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.bone.2009.10.020","article-title":"Comparison of hip fracture risk prediction by femoral aBMD to experimentally measured factor of risk","volume":"46","author":"Roberts","year":"2010","journal-title":"Bone."},{"key":"2024020319003312100_jbmr2568-bib-0035","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1138\/20060248","article-title":"Mineralization, microdamage , and matrix: How bisphosphonates influence material properties of bone","volume":"4","author":"Allen","year":"2007","journal-title":"BoneKEy-Osteovision."},{"issue":"8","key":"2024020319003312100_jbmr2568-bib-0036","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1002\/jbmr.73","article-title":"Microindentation for in vivo measurement of bone tissue mechanical properties in humans","volume":"25","author":"Diez-Perez","year":"2010","journal-title":"J Bone Miner Res."},{"issue":"4","key":"2024020319003312100_jbmr2568-bib-0037","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.bone.2007.07.007","article-title":"Automatic segmentation of cortical and trabecular compartments based on a dual threshold technique for in vivo micro-CT bone analysis","volume":"41","author":"Buie","year":"2007","journal-title":"Bone."},{"issue":"7","key":"2024020319003312100_jbmr2568-bib-0038","doi-asserted-by":"crossref","first-page":"867","DOI":"10.2337\/diab.37.7.867","article-title":"Collagen browning and cross-linking are increased in chronic experimental hyperglycemia. Relevance to diabetes and aging","volume":"37","author":"Monnier","year":"1988","journal-title":"Diabetes."},{"issue":"5","key":"2024020319003312100_jbmr2568-bib-0039","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/S0020-1383(02)00076-1","article-title":"Predictive geometric factors in a standardized model of femoral neck fracture. Experimental study of cadaveric human femurs","volume":"33","author":"Kukla","year":"2002","journal-title":"Injury."},{"issue":"3","key":"2024020319003312100_jbmr2568-bib-0040","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1359\/jbmr.081108","article-title":"Hip fractures and the contribution of cortical versus trabecular bone to femoral neck strength","volume":"24","author":"Holzer","year":"2009","journal-title":"J Bone Miner Res."},{"key":"2024020319003312100_jbmr2568-bib-0041","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1196\/annals.1333.082","article-title":"Advanced glycation end products and bone loss during aging","volume":"1043","author":"Odetti","year":"2005","journal-title":"Ann N Y Acad Sci."},{"key":"2024020319003312100_jbmr2568-bib-0042","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1007\/s00198-013-2319-4","article-title":"Differences in non-enzymatic glycation and collagen cross-links between human cortical and cancellous bone","volume":"24","author":"Karim","year":"2013","journal-title":"Osteoporos Int."},{"issue":"9321","key":"2024020319003312100_jbmr2568-bib-0043","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1016\/S0140-6736(02)08761-5","article-title":"Diagnosis of osteoporosis and assessment of fracture risk","volume":"359","author":"Kanis","year":"2002","journal-title":"Lancet."},{"issue":"5","key":"2024020319003312100_jbmr2568-bib-0044","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1359\/jbmr.091104","article-title":"Age- and gender-related differences in the geometric properties and biomechanical significance of intracortical porosity in the distal radius and tibia","volume":"25","author":"Burghardt","year":"2010","journal-title":"J Bone Miner Res."},{"issue":"6","key":"2024020319003312100_jbmr2568-bib-0045","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1002\/jbmr.2167","article-title":"Cortical porosity identifies women with osteopenia at increased risk for forearm fractures","volume":"29","author":"Bala","year":"2014","journal-title":"J Bone Miner Res."},{"issue":"1\u20132","key":"2024020319003312100_jbmr2568-bib-0046","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0047-6374(98)00119-5","article-title":"Mechanisms of maturation and ageing of collagen","volume":"106","author":"Bailey","year":"1998","journal-title":"Mech Ageing Dev."},{"issue":"6","key":"2024020319003312100_jbmr2568-bib-0047","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.bone.2005.07.019","article-title":"Trabecular microfracture and the influence of pyridinium and non-enzymatic glycation-mediated collagen cross-links","volume":"37","author":"Hernandez","year":"2005","journal-title":"Bone."},{"issue":"10","key":"2024020319003312100_jbmr2568-bib-0048","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1093\/rheumatology\/keg324","article-title":"Advanced glycation end-products pentosidine and N epsilon-carboxymethyllysine are elevated in serum of patients with osteoporosis","volume":"42","author":"Hein","year":"2003","journal-title":"Rheumatology (Oxford)."},{"issue":"3","key":"2024020319003312100_jbmr2568-bib-0049","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1359\/JBMR.0301244","article-title":"Biochemical markers of bone metabolism and prediction of fracture in elderly women","volume":"19","author":"Gerdhem","year":"2004","journal-title":"J Bone Miner Res."},{"issue":"3","key":"2024020319003312100_jbmr2568-bib-0050","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1359\/jbmr.081108","article-title":"Hip fractures and the contribution of cortical versus trabecular bone to femoral neck strength","volume":"24","author":"Holzer","year":"2009","journal-title":"J Bone Miner Res."},{"key":"2024020319003312100_jbmr2568-bib-0051","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1097\/00003086-199609000-00020","article-title":"Patients with femoral neck and intertrochanteric fractures","author":"Koval","year":"1996","journal-title":"Are they the same? Clin Orthop Relat Res."},{"key":"2024020319003312100_jbmr2568-bib-0052","first-page":"132","article-title":"Age- and sex-specific incidence of femoral neck and trochanteric fractures. An analysis based on 20,538 fractures in Stockholm County, Sweden, 1972\u20131981","volume":"1987","author":"Hedlund","journal-title":"Clin Orthop Relat Res."},{"key":"2024020319003312100_jbmr2568-bib-0053","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1016\/j.bone.2011.03.682","article-title":"Male-female differences in the association between incident hip fracture and proximal femoral strength: a finite element analysis study","volume":"48","author":"Keyak","year":"2011","journal-title":"Bone."},{"key":"2024020319003312100_jbmr2568-bib-0054","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.bone.2013.07.028","article-title":"Effect of finite element model loading condition on fracture risk assessment in men and women: the AGES-Reykjavik study","volume":"57","author":"Keyak","year":"2013","journal-title":"Bone."},{"issue":"11","key":"2024020319003312100_jbmr2568-bib-0055","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/S0021-9290(98)00110-9","article-title":"Human vertebral body apparent and hard tissue stiffness","volume":"31","author":"Hou","year":"1998","journal-title":"J Biomech."},{"issue":"2","key":"2024020319003312100_jbmr2568-bib-0056","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S8756-3282(99)00092-7","article-title":"Biomechanical effects of intraspecimen variations in trabecular architecture: a three-dimensional finite element study","volume":"25","author":"Yeh","year":"1999","journal-title":"Bone."},{"issue":"5","key":"2024020319003312100_jbmr2568-bib-0057","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/S8756-3282(98)00030-1","article-title":"High-resolution magnetic resonance imaging: three-dimensional trabecular bone architecture and biomechanical properties","volume":"22","author":"Majumdar","year":"1998","journal-title":"Bone."},{"issue":"2","key":"2024020319003312100_jbmr2568-bib-0058","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1007\/s00198-013-2452-0","article-title":"The associations between QCT-based vertebral bone measurements and prevalent vertebral fractures depend on the spinal locations of both bone measurement and fracture","volume":"25","author":"Anderson","year":"2014","journal-title":"Osteoporos Int."},{"issue":"2","key":"2024020319003312100_jbmr2568-bib-0059","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1002\/jbmr.2033","article-title":"Microstructural failure mechanisms in the human proximal femur for sideways fall loading","volume":"29","author":"Nawathe","year":"2014","journal-title":"J Bone Miner Res."},{"key":"2024020319003312100_jbmr2568-bib-0060","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1002\/(SICI)1097-4636(20000305)49:3<380::AID-JBM11>3.0.CO;2-W","article-title":"Fracture toughness is dependent on bone location--a study of the femoral neck, femoral shaft, and the tibial shaft","volume":"49","author":"Brown","year":"2000","journal-title":"J Biomed Mater Res."},{"issue":"1","key":"2024020319003312100_jbmr2568-bib-0061","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1002\/jbmr.5650110107","article-title":"Heterogeneity of the skeleton: comparison of the trabecular microarchitecture of the spine , the iliac crest, the femur, and the calcaneus","volume":"11","author":"Amling","year":"1996","journal-title":"J Bone Miner Res."}],"container-title":["Journal of Bone and Mineral Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbmr.2568","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/30\/12\/2207\/56567407\/jbmr2568.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/30\/12\/2207\/56567407\/jbmr2568.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T14:54:29Z","timestamp":1710341669000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbmr\/article\/30\/12\/2207-2214\/7599157"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,8]]},"references-count":61,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2015,6,8]]},"published-print":{"date-parts":[[2015,12,1]]}},"URL":"https:\/\/doi.org\/10.1002\/jbmr.2568","relation":{},"ISSN":["0884-0431","1523-4681"],"issn-type":[{"value":"0884-0431","type":"print"},{"value":"1523-4681","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2015,12,1]]},"published":{"date-parts":[[2015,6,8]]}}}