{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T02:13:45Z","timestamp":1792030425822,"version":"4.4.0"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T00:00:00Z","timestamp":1436832000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AR\u2010060055"],"award-info":[{"award-number":["AR\u2010060055"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,1,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>\u2003<\/jats:title>\n                  <jats:p>The host response to pathogens through nuclear factor \u03baB (NF-\u03baB) is an essential defense mechanism for eukaryotic organisms. NF-\u03baB-mediated host responses inhibit bone and other connective tissue synthesis and are thought to affect the transcription of matrix proteins through multiple indirect pathways. We demonstrate that inhibiting NF-\u03baB in osteoblasts increases osteocalcin expression in vivo in mice with periodontal disease. Mutating NF-\u03baB binding sites on osteocalcin (OC) or bone sialoprotein (Bsp) promoters rescues the negative impact of NF-\u03baB on their transcription and that NF-\u03baB can inhibit Wnt- and Bmp-induced OC and Bsp transcription, even when protein synthesis is inhibited, indicating a direct effect of NF-\u03baB. This inhibition depends on p65-p50 NF-\u03baB heterodimer formation and deacetylation by HDAC1 but is not affected by the noncanonical NF-\u03baB pathway. Moreover, NF-\u03baB reduces Runx2 and \u03b2-catenin binding to OC\/Bsp promoters independently of their nuclear localization. Thus, inflammatory signals stimulate the direct interaction of NF-\u03baB with response elements to inhibit binding of \u03b2-catenin and Runx2 binding to nearby consensus sites and reduce expression of matrix proteins. This direct mechanism provides a new explanation for the rapid decrease in new bone formation after inflammation-related NF-\u03baB activation. \u00a9 2015 American Society for Bone and Mineral Research.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/jbmr.2592","type":"journal-article","created":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T15:40:36Z","timestamp":1436888436000},"page":"52-64","source":"Crossref","is-referenced-by-count":42,"title":["NF-\u03baB Has a Direct Role in Inhibiting Bmp- and Wnt-Induced Matrix Protein Expression"],"prefix":"10.1093","volume":"31","author":[{"given":"Rohinton S","family":"Tarapore","sequence":"first","affiliation":[{"name":"Department of PeriodonticsSchool of Dental MedicineUniversity of PennsylvaniaPhiladelphiaPAUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of PeriodonticsSchool of Dental MedicineUniversity of 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